| Davinci Automation Ltd | Information & communication | 2014 |
| Davis Lamp Ltd | Hospitality | 2022 |
| DB Courier Solutions Ltd | Transport & logistics | 2023 |
| DB Midlands Consultancy Ltd | Professional & scientific | 2017 |
| DBI Garage Services Ltd | Wholesale & retail | 2025 |
| DBS Processing Limited | Manufacturing | 2013 |
| DCP (Midlands) Ltd | Real estate | 2024 |
| DCT Bricklayers Limited | Construction | 2017 |
| DE7 Fitness Limited | Other services | 2013 |
| Deadstock Fabrics Limited | Wholesale & retail | 2025 |
| Deano Ventures Ltd | Wholesale & retail | 2025 |
| Deans JAP Imports Ltd | Wholesale & retail | 2019 |
| Deans Properties Ltd | Real estate | 2023 |
| Decadent Dwellings Limited | Construction | 2024 |
| Decorative Dreams Ltd | Other services | 2024 |
| Delilah's Bar & Bistro Ltd | Hospitality | 2024 |
| Delta Electrical & GAS Services Limited | Construction | 2015 |
| Delvin Trailer Consultants Ltd | Professional & scientific | 2026 |
| Denton's Decorating Limited | Construction | 2022 |
| Derby Cold Stores Limited | Manufacturing | 2004 |
| Derby Knotweed Co Ltd | Construction | 2025 |
| Derbyshire Building & Management Ltd | Construction | 2026 |
| Derbyshire Coatings Limited | Construction | 2025 |
| Derbyshire Designers Ltd | Wholesale & retail | 2022 |
| Derbyshire Food and Drink Fair Ltd | Extraterritorial | 2024 |
| Derbyshire Properties Ltd | Real estate | 2023 |
| Derbyshire Tuition Group Ltd | Education | 2025 |
| Derbyshire Wedding Events Ltd | Arts & recreation | 2025 |
| Derwent Roofing Services Limited | Construction | 1999 |
| Derya Pizza Ltd | Hospitality | 2025 |
| Design Exterior (Midlands) Ltd | Construction | 2021 |
| Design Render Co Ltd | Professional & scientific | 2023 |
| Designer Glass Limited | Other services | 2002 |
| Detailing and Training Centre Ltd | Wholesale & retail | 2024 |
| DG Plastering Ltd | Construction | 2017 |
| DG Plumbing and Heating (Derby) Limited | Construction | 2016 |
| DH Site Management Ltd | Professional & scientific | 2025 |
| Dharma Studios Limited | Professional & scientific | 2023 |
| Dialledparts Limited | Wholesale & retail | 2025 |
| Digital Aerial Installations Ltd | Other services | 2015 |
| Digital FX Ltd | Information & communication | 2006 |
| Direct Pumps & Tanks Ltd | Water & waste | 1996 |
| Direct Pumps & Tanks Service Limited | Professional & scientific | 2020 |
| Direct-To-Plate Limited | Manufacturing | 1996 |
| Diverse Electrical Solutions Ltd | Construction | 2022 |
| DIY Drylining Ltd | Construction | 2014 |
| Dizzy Dwellings Ltd | Real estate | 2021 |
| DJ Slipz Ltd | Information & communication | 2024 |
| DJ Sweeps Ltd | Administrative & support | 2023 |
| DJH Commercial Ltd | Construction | 2024 |
| DJS Scaffolding Ltd | Construction | 2026 |
| DKK UK Group Ltd | Transport & logistics | 2025 |
| DMW Design & Build Ltd | Construction | 2024 |
| DNB Electrical & Mechanical Ltd | Construction | 2023 |
| Donald Ward Limited | Water & waste | 1976 |
| Donchor Property Ltd | Real estate | 2023 |
| Double Apex TV Ltd | Wholesale & retail | 2020 |
| Doughty Electrical Co Ltd | Manufacturing | 2025 |
| DPM Plumb, Heat & Roofing Ltd | Construction | 2014 |
| DPS Event Management Ltd | Administrative & support | 2025 |
| DQM & Associates Limited | Health & social care | 2025 |
| Draughting & Estimating Ltd | Professional & scientific | 2018 |
| DRC IT Solutions Limited | Information & communication | 2022 |
| DRC Ltd | Construction | 2019 |
| Dream Comps Ltd | Wholesale & retail | 2019 |
| Dremm Packaging Limited | Manufacturing | 1984 |
| DRT Rail Ltd | Construction | 2023 |
| DSB Electrics Ltd | Construction | 2016 |
| Dualmist International Limited | Administrative & support | 2012 |
| Dualmist Limited | Public administration | 2015 |
| Duro Design and Build Ltd | Construction | 2021 |
| Duru Lina Ltd | Wholesale & retail | 2025 |
| DV Fabrications Ltd | Manufacturing | 2021 |
| DWB Groundworks Derby Limited | Construction | 2020 |
| DZI Distributions Limited | Wholesale & retail | 2024 |
| E & a Property & Investment Ltd | Real estate | 2021 |
| E & P Allards Ltd | Real estate | 2016 |
| E & P Enderleigh Ltd | Real estate | 2016 |
| E.C.I (Europe) Limited | Manufacturing | 2008 |
| E.J. Mcgovern Crane Hire Ltd | Construction | 2003 |
| Eagle (G.E.T.) Group Limited | Manufacturing | 2021 |
| Eagle (G.E.T.) Manufacturing Limited | Manufacturing | 1993 |
| Eagle Plant Services (Property Management) Limited | Real estate | 1986 |
| Eagle Security Systems Limited | Administrative & support | 1984 |
| Earl & Pelham Ltd | Real estate | 2015 |
| Earnie Smith Properties Ltd | Real estate | 2025 |
| Earth and Turf Garden Maintenance Ltd | Administrative & support | 2012 |
| Eason Smythe Legal Services Limited | Professional & scientific | 2019 |
| East Midlands Blood Bikes Ltd | Transport & logistics | 2019 |
| East Midlands GAS Limited | Administrative & support | 2017 |
| East Midlands GAS Services Limited | Construction | 2025 |
| East Midlands Hydraulics Ltd | Manufacturing | 2014 |
| East Midlands Medical Services Ltd | Education | 2015 |
| East Midlands Pickleball Centre Ltd | Arts & recreation | 2025 |
| East Midlands Property Maintenance Limited | Administrative & support | 2004 |
| East Midlands Recycling Limited | Wholesale & retail | 2011 |
| East Renewables Ltd | Construction | 2022 |
| Eastmidlands Business Solution Limited | Professional & scientific | 2014 |
| Ecgtechnologies Ltd | Wholesale & retail | 2026 |
| Eco Thermal Walls Solutions Ltd | Construction | 2019 |