| Dynamic Wind Power Ltd | Manufacturing | 2018 |
| Dynamik Beats Limited | Administrative & support | 2022 |
| Dyson Lettings Limited | Real estate | 2024 |
| Dzashes Companies Limited | Health & social care | 2015 |
| D’Choice African Food Store Ltd | Wholesale & retail | 2023 |
| E & M European Limited | Wholesale & retail | 2018 |
| E & S Property Services Limited | Administrative & support | 2018 |
| E - Systems X Ltd | Information & communication | 2022 |
| E a Miller Advisory Services Ltd | Financial services | 2017 |
| E B Homes Ltd | Real estate | 2017 |
| E Batty (Holdings) Limited | Professional & scientific | 2016 |
| E L Aesthetics by KH Limited | Health & social care | 2024 |
| E P DEE and SON Limited | Agriculture & fishing | 1983 |
| E Tech Plumbing Ltd | Construction | 2026 |
| E&F Property Builder Ltd | Real estate | 2025 |
| E&K Hand Car Wash Ltd | Other services | 2014 |
| E&M Powder Coating & Shotblasting Ltd | Transport & logistics | 2017 |
| E-Solve Consulting Ltd | Education | 2023 |
| E-Spaces Design and Create Ltd | Construction | 2022 |
| E. & W.R.Launderette Co. Limited | Other services | 1949 |
| E. Mercer & Co (Hull) Limited | Wholesale & retail | 1904 |
| E.E.M Services Ltd | Construction | 2023 |
| E.M. Kapica Construction Ltd | Construction | 2016 |
| E.M.N Export on the Wold Limited | Wholesale & retail | 2014 |
| E.S.L. (GB) Limited | Manufacturing | 2010 |
| E.T Electrical Solutions Ltd | Construction | 2022 |
| E2 Engineering Ltd | Wholesale & retail | 2020 |
| E4L Ltd | Real estate | 2025 |
| E52 Ltd | Arts & recreation | 2013 |
| EA Dealz Ltd | Real estate | 2026 |
| EAA Ltd | Transport & logistics | 2025 |
| EAA Martins Ltd | Manufacturing | 2024 |
| Eagle Close Bridlington Management Company Limited | Real estate | 2023 |
| Eagle Film Capital Limited | Information & communication | 2017 |
| Eagle House Pharma Consulting Ltd | Administrative & support | 2025 |
| Eaglefields Group Ltd | Wholesale & retail | 2024 |
| EAJ Global F Ltd | Information & communication | 2023 |
| EAJ Global FM Ltd | Administrative & support | 2025 |
| EAJ Global Ltd | Information & communication | 2021 |
| EAR Fresh Microsuction Limited | Health & social care | 2024 |
| Earnrol Limited | Education | 2025 |
| Earthe Grounding Limited | Manufacturing | 2025 |
| Earworx UK Ltd | Health & social care | 2022 |
| Easihold Ltd | Manufacturing | 2026 |
| East Hull Car Sales Limited | Wholesale & retail | 2017 |
| East Birdman Limited | Professional & scientific | 2025 |
| East Coast Cardiology Services Ltd | Health & social care | 2022 |
| East Coast Crazy Kids Ltd | Arts & recreation | 2016 |
| East Coast Line Marking Limited | Construction | 2011 |
| East Coast Padel Limited | Arts & recreation | 2025 |
| East Coast Vehicle Solutions Ltd | Wholesale & retail | 2020 |
| East Electrics Ltd | Construction | 2023 |
| East END Nurseries (Keyingham) Limited | Agriculture & fishing | 1972 |
| East Halton Hotel Ltd | Hospitality | 2024 |
| East Hull Community Farm Limited | Education | 1992 |
| East Hull Local Limited | Wholesale & retail | 2024 |
| East Hull MOT and Repair Centre Limited | Wholesale & retail | 2019 |
| East Hull Service Centre Limited | Wholesale & retail | 2023 |
| East Hull Tyres Ltd | Wholesale & retail | 2023 |
| East Ocean (Hull) Ltd | Hospitality | 2021 |
| East Park Childminding Limited | Health & social care | 2026 |
| East Park Shop Ltd | Wholesale & retail | 2025 |
| East Riding Ambulance Service Ltd | Health & social care | 2022 |
| East Riding Bodywork Ltd | Wholesale & retail | 2025 |
| East Riding Care Services Limited | Financial services | 2024 |
| East Riding Construction and Landscaping Limited | Construction | 2018 |
| East Riding County Football Association Limited | Arts & recreation | 1999 |
| East Riding Drainage and Jetting Limited | Construction | 2019 |
| East Riding Enterprises Ltd | Professional & scientific | 2022 |
| East Riding Fabrications Limited | Manufacturing | 1994 |
| East Riding Farmers Limited | Real estate | 1940 |
| East Riding Growers Limited | Other services | 1993 |
| East Riding Horse Boxes Limited | Manufacturing | 2020 |
| East Riding Kitchens Ltd | Manufacturing | 2023 |
| East Riding Laboratories Limited | Professional & scientific | 2003 |
| East Riding Physio Therapy Limited | Health & social care | 2011 |
| East Riding Plumbing and Heating Services Limited | Construction | 2003 |
| East Riding Projects & Facilities Services" Ltd | Construction | 2022 |
| East Riding Recovery Ltd | Wholesale & retail | 2023 |
| East Riding Repairs Limited | Manufacturing | 2015 |
| East Riding Securities Limited | Real estate | 1927 |
| East Riding Services Ltd | Construction | 2019 |
| East Riding Transport Limited | Transport & logistics | 2023 |
| East Side Fisheries Limited | Agriculture & fishing | 2013 |
| East Yorks Group Nvtec Ltd | Arts & recreation | 2015 |
| East Yorkshire Aluminium & Glass Limited | Manufacturing | 1975 |
| East Yorkshire Auto Valeting Ltd | Administrative & support | 2020 |
| East Yorkshire Building & Landscaping Ltd | Construction | 2020 |
| East Yorkshire Carpet & BED Limited | Wholesale & retail | 2004 |
| East Yorkshire Caterers Limited | Hospitality | 2018 |
| East Yorkshire Community Hub CIC | Education | 2025 |
| East Yorkshire Dent Removal Ltd | Wholesale & retail | 2024 |
| East Yorkshire Electronics Ltd | Construction | 2022 |
| East Yorkshire Engineering Services Ltd | Professional & scientific | 2021 |
| East Yorkshire Fascias Limited | Manufacturing | 2000 |
| East Yorkshire Forklifts Limited | Manufacturing | 2011 |
| East Yorkshire Groundwork Solutions Limited | Construction | 2017 |
| East Yorkshire Hard Surface Repair Limited | Construction | 2021 |
| East Yorkshire Haulage Ltd | Transport & logistics | 2018 |
| East Yorkshire Holdings Limited | Real estate | 2019 |