| Energy Innovation Limited | Wholesale & retail | 2001 |
| Energy Innovation Services Ltd | Manufacturing | 2018 |
| Energy Management Installations Ltd | Manufacturing | 2011 |
| Energy Retrofit Ltd | Construction | 2025 |
| Energydirect (GB) Ltd | Administrative & support | 2026 |
| Enertech Power Limited | Construction | 2021 |
| Engaged Learning Limited | Administrative & support | 2012 |
| Engineered Timber Buildings Limited | Manufacturing | 2004 |
| Engineering Spares 24/7 Ltd | Professional & scientific | 2018 |
| Englerd Ltd | Transport & logistics | 2022 |
| Englewood Properties Limited | Real estate | 2018 |
| Enkae Prestige Motors Ltd | Wholesale & retail | 2016 |
| Enri Limited | Wholesale & retail | 2023 |
| Enterprise Foundation (Kirklees) Ltd | Administrative & support | 2007 |
| Enterprise Textiles Limited | Manufacturing | 1958 |
| Entertainment & Security Ltd | Administrative & support | 2023 |
| Entropy Labs Ltd | Information & communication | 2023 |
| Entryevents Limited | Wholesale & retail | 2026 |
| Enveh Limited | Real estate | 2009 |
| Enviro-Cap Limited | Manufacturing | 2013 |
| Envirodress Ltd | Wholesale & retail | 2014 |
| Enviromental Energy Limited | Construction | 2010 |
| Environment Kirklees Ltd | Professional & scientific | 1997 |
| Environmental Defence Systems Limited | Wholesale & retail | 2007 |
| Environmental Fuel Technology Ltd | Manufacturing | 2013 |
| Enviroplus+ Consulting Limited | Professional & scientific | 2020 |
| Enzo 1 Properties Limited | Real estate | 2024 |
| EO Healthhub Connect (Eohhc) Ltd | Hospitality | 2025 |
| EO Sector Ltd. | Information & communication | 2025 |
| EON Essentials Ltd | Wholesale & retail | 2023 |
| EPC4ENERGY Ltd | Professional & scientific | 2023 |
| Epic Designs Ltd | Wholesale & retail | 2015 |
| Epiphany Consulting Ltd | Professional & scientific | 2003 |
| EPL Automotive Ltd | Wholesale & retail | 2024 |
| EPL Interiors Ltd | Professional & scientific | 2025 |
| Epsom Consultancy Ltd | Professional & scientific | 2020 |
| EQ Estates Ltd | Real estate | 2022 |
| EQB Storage Ltd | Real estate | 2022 |
| Equa Pharma Holdings Limited | Financial services | 2021 |
| Equatek Ltd | Construction | 1998 |
| Equestrian Construction Limited | Construction | 2021 |
| Equilibrium Assessors Ltd | Financial services | 2012 |
| Equilibrium Risk Ltd | Administrative & support | 2013 |
| Equineu Ltd | Wholesale & retail | 2017 |
| Equinox Property Group Limited | Real estate | 2024 |
| Erdingtonconnect Ltd | Extraterritorial | 2025 |
| ERE Cleaning/Care Services Ltd | Administrative & support | 2024 |
| Eric`S Restaurant Limited | Hospitality | 2008 |
| Eriya Sophia Limited | Wholesale & retail | 2025 |
| Erkan (Hudd) Ltd | Hospitality | 2016 |
| Ernest Warren Properties Limited | Real estate | 2020 |
| Errol Consultancy Limited | Professional & scientific | 2019 |
| ES FAM Ltd | Transport & logistics | 2018 |
| ES Pharma Ltd | Wholesale & retail | 2023 |
| Esba Homes Ltd | Real estate | 2019 |
| Escapehubgateway Ltd | Hospitality | 2024 |
| Esha Knitwear Limited | | 1983 |
| Eshal Limited | Health & social care | 2020 |
| ESJ2016 Ltd | Real estate | 2016 |
| ESP Accountancy Services Ltd | Professional & scientific | 2005 |
| ESP Business Solutions (Huddersfield) Ltd | Professional & scientific | 2025 |
| Esquire ACC UK Limited | Professional & scientific | 2024 |
| Esro Solutions Ltd | Real estate | 2020 |
| Essa Solutions Ltd | Administrative & support | 2013 |
| Essamarketo Limited | Wholesale & retail | 2025 |
| Esse Commerce Ltd | Wholesale & retail | 2022 |
| Essencio Ltd | Extraterritorial | 2024 |
| Essential Glow Ltd | Wholesale & retail | 2024 |
| Essential Hub 360 Ltd | Wholesale & retail | 2025 |
| Essential Wellness Ltd | Extraterritorial | 2015 |
| Essentialist Health Ltd | Health & social care | 2020 |
| Essin Limited | Administrative & support | 2023 |
| Essuno Ltd | Professional & scientific | 2010 |
| Estaff Recruitment Global Ltd | Administrative & support | 2025 |
| Estate 8 Holiday Homes Ltd | Hospitality | 2021 |
| Estate 8 Ltd | Real estate | 2020 |
| Estate Planners Limited | Professional & scientific | 2016 |
| Esther O Ltd | Hospitality | 2025 |
| Estiman Services Limited | Other services | 2016 |
| Esupbase UK Ltd | Information & communication | 2020 |
| ET Electrical Yorkshire Ltd | Construction | 2025 |
| ETA Investments Limited | Financial services | 2023 |
| Etail Fulfilment Services Limited | Extraterritorial | 2015 |
| Etalonne Ltd | Other services | 2023 |
| Eternal Bond Permanent Jewellery Limited | Wholesale & retail | 2023 |
| Ethereal Star Investment Ltd | Wholesale & retail | 2014 |
| Ethica Resolve HR Limited | Administrative & support | 2025 |
| Ethos Associated Ltd | Professional & scientific | 2024 |
| Etincelle Brillante Trading Limited | Wholesale & retail | 2021 |
| ETP Chemicals Limited | Wholesale & retail | 1999 |
| Etpf UK Ltd | Arts & recreation | 2025 |
| Ettelocin Limited | Administrative & support | 2017 |
| EU Autos Limited | Wholesale & retail | 2025 |
| Eudaimonic Consulting Ltd | Information & communication | 2024 |
| Eugenie's Flavour Station Ltd | Hospitality | 2025 |
| Euniq Consulting Limited | Professional & scientific | 2026 |
| Euphoria Restaurants Ltd | Hospitality | 2024 |
| Euro (Hudds) Ltd | Wholesale & retail | 2006 |
| Euro Direct International Limited | Other services | 2000 |
| Euro Home & Gift Ltd | Wholesale & retail | 2014 |