| Drive Talent Solutions Ltd | Professional & scientific | 2025 |
| Drive to Dream Ltd | Transport & logistics | 2024 |
| Drivebuzzmedia Ltd | Professional & scientific | 2025 |
| Driven Logistics Solutions Ltd | Wholesale & retail | 2018 |
| Driver Residential Limited | Real estate | 2026 |
| Drivers Service UK Ltd | Transport & logistics | 2024 |
| Drivingskills Ltd | Education | 2010 |
| DRM Flooring Limited | Wholesale & retail | 2022 |
| DRN Nutrition Group Ltd | Arts & recreation | 2025 |
| Drone Pilot Limited | Professional & scientific | 2019 |
| Drop Logistics Limited | Transport & logistics | 2023 |
| Dropack International Limited | Administrative & support | 2000 |
| Dropo Tech Ltd | Transport & logistics | 2023 |
| DRY EYE Direct Limited | Extraterritorial | 2023 |
| DRY EYE Revolution Limited | Extraterritorial | 2023 |
| DRY Hill Barn Ltd | Construction | 2019 |
| DRY Stone Walling Yorkshire Ltd | Construction | 2025 |
| Drybrook Pharmacy Limited | Wholesale & retail | 2004 |
| Dryclough Grocery Store Ltd | Wholesale & retail | 2023 |
| Drystone Wallers & Landscapers Ltd | Construction | 2025 |
| DS Bay Services Limited | Extraterritorial | 2024 |
| DS Custom Clothing Ltd | Wholesale & retail | 2023 |
| DS Projects and Design Solutions Ltd | Professional & scientific | 2023 |
| DS Recruiting Services Ltd | Administrative & support | 2010 |
| DS Sparkles Ltd | Administrative & support | 2025 |
| DS Trading(Uk) Ltd | Health & social care | 2023 |
| DS Wind Energy Limited | Energy | 2013 |
| DSA Furniture Ltd | Manufacturing | 2022 |
| DSA Travel Ltd | Transport & logistics | 2024 |
| DSC Elite Football Academy Limited | Arts & recreation | 2016 |
| DSE (Yorkshire) Ltd | Professional & scientific | 2019 |
| DSF Autoparts Ltd | Wholesale & retail | 2023 |
| Dsmentorshipgroup Ltd | Education | 2025 |
| DSO Local Express Ltd | Wholesale & retail | 2022 |
| DT Properties (Yorkshire) Ltd | Real estate | 2024 |
| DT Stainless Fabricators Ltd | Manufacturing | 2013 |
| DTA Groundworks Ltd | Construction | 2014 |
| DTA Operations Consultancy Ltd | Professional & scientific | 2025 |
| DTI Enterprises Limited | Wholesale & retail | 2021 |
| DTX Developments Ltd | Real estate | 2023 |
| Dual Perspective Limited | Professional & scientific | 2025 |
| Dual Seal Glass Holdings Limited | Financial services | 2019 |
| Dubai Store Huddersfield Limited | Wholesale & retail | 2026 |
| Dubbers Property Ltd | Real estate | 2022 |
| Dubbers Sports Ltd | Wholesale & retail | 2015 |
| Duck & Spoon Bistro Limited | Real estate | 2016 |
| Duckett Investments Limited | Financial services | 2018 |
| Duckworth Lane Convenience Ltd | Wholesale & retail | 2025 |
| Duffin & Peace Limited | Professional & scientific | 2002 |
| Dugdale 1896 Group Limited | Professional & scientific | 2025 |
| Dugdale Holdings Limited | Wholesale & retail | 2016 |
| Dugdale Property Holdings Limited | Real estate | 2016 |
| Dugdale Property Limited | Real estate | 1924 |
| Dujj Holdings Ltd | Financial services | 2026 |
| Dunk Logistics Ltd | Transport & logistics | 2025 |
| Dunnigan Instruments Limited | Wholesale & retail | 2016 |
| Dunsley Holdings Limited | Extraterritorial | 2002 |
| Dunwan DAM Wind Farm Limited | Energy | 2026 |
| DUO Trading Ltd | Wholesale & retail | 2023 |
| Duolc Solutions Ltd | Information & communication | 2023 |
| Dura Paint Ltd | Wholesale & retail | 2025 |
| Durand Supply Ltd | Wholesale & retail | 2024 |
| Durkin-Jones Investments Ltd | Real estate | 2024 |
| Durning Limited | Professional & scientific | 2020 |
| Durwesh Limited | Manufacturing | 2020 |
| Dust and Drizzle Ltd | Manufacturing | 2025 |
| DVF Products Limited | Manufacturing | 2014 |
| DVO Developments Limited | Construction | 2019 |
| DW Exhibitions Ltd | Administrative & support | 2018 |
| DW Roofing Yorkshire Limited | Construction | 2017 |
| Dwell Works Ltd | Construction | 2024 |
| Dwit Mehta Animation Limited | Arts & recreation | 2015 |
| Dwsa Consultancy Limited | Professional & scientific | 2023 |
| DWW Digital Solutions Limited | Information & communication | 2020 |
| DXB Services Ltd | Information & communication | 2025 |
| DY Pharma Ltd. | Health & social care | 2024 |
| Dye-Rite Limited | Manufacturing | 2021 |
| DYK Limited | Professional & scientific | 2019 |
| Dynamic International Ltd | Wholesale & retail | 2022 |
| Dynamiq Soloutions Limited | Construction | 2025 |
| Dynamita UK Ltd | Information & communication | 2023 |
| Dynpro UK Limited | Information & communication | 2007 |
| Dyson Brothers Construction Ltd | Construction | 2025 |
| Dyson Homes Limited | Real estate | 2015 |
| Dyswin Holdings Limited | Financial services | 2020 |
| DZ International Ltd | Wholesale & retail | 2023 |
| DZR Holdings Ltd | Financial services | 2024 |
| E & a Health Ltd | Health & social care | 2011 |
| E & P Risk Services Limited | Professional & scientific | 2009 |
| E and J Health Ltd | Health & social care | 2023 |
| E Beaumont Limited | Wholesale & retail | 1999 |
| E C Plastering Ltd | Construction | 2013 |
| E DAR Consultancy Ltd | Professional & scientific | 2023 |
| E Fountain Ltd | Professional & scientific | 2016 |
| E H Aggregates Ltd | Wholesale & retail | 2021 |
| E J L Joinery Ltd | Construction | 2015 |
| E K Motor Group Ltd | Wholesale & retail | 2026 |
| E Khokhar Ltd | Health & social care | 2008 |
| E L F Developments Ltd | Construction | 2021 |
| E Omih Properties Ltd | Real estate | 2021 |