| Super Squad Ltd | Wholesale & retail | 2015 |
| Super Store Butchery Limited | Wholesale & retail | 2020 |
| Super Ultra Cleaning Services Limited | Administrative & support | 2025 |
| Superior Furniture Importers Ltd | Administrative & support | 2012 |
| Supersam HD Ltd | Wholesale & retail | 2025 |
| Supervalue Trading Limited | Wholesale & retail | 2022 |
| Supplement Warehouse Ltd | Wholesale & retail | 2014 |
| Supplymint Ltd | Wholesale & retail | 2025 |
| Support to Recovery | Health & social care | 2007 |
| Supreme Accountants of UK Ltd | Professional & scientific | 2023 |
| Supreme Bakery Ltd | Hospitality | 2024 |
| Supreme Destination Limited | Hospitality | 2018 |
| Supreme Trackdays Ltd | Arts & recreation | 2020 |
| Supwing Ltd | Real estate | 2022 |
| Suravi Limited | Real estate | 2012 |
| Sure Start Staff Limited | Administrative & support | 2021 |
| Surefix Motoring Ltd | Wholesale & retail | 2025 |
| Surefoot Systems UK Limited | Construction | 2003 |
| Surface Repair Huddersfield Ltd | Construction | 2018 |
| Surge Recruitment Ltd | Administrative & support | 2024 |
| Surgeonomics Limited | Health & social care | 2021 |
| Surgical Green Limited | Manufacturing | 2025 |
| Survey to Site (Yorkshire) Ltd | Construction | 2020 |
| Survigilance Ltd | Information & communication | 2019 |
| Surzak International Ltd | Wholesale & retail | 2023 |
| Sushi Fiesta 4 ALL Ltd | Hospitality | 2025 |
| Sustainable Holdings Yorkshire Limited | Real estate | 2025 |
| Sustainable Packaging Designs Limited | Professional & scientific | 2023 |
| Sustainable Wellbeing Therapies Ltd | Health & social care | 2020 |
| Sutcliffe Helme Ltd | Manufacturing | 2006 |
| Sutherland/Moss Consulting Limited | Professional & scientific | 2021 |
| Sutton Global Ltd | Wholesale & retail | 2023 |
| SVC Construction Works Limited | Construction | 2025 |
| SVN Limited | Real estate | 2015 |
| SVR Automotive Ltd | Wholesale & retail | 2024 |
| SW Echocardiography Ltd | Health & social care | 2025 |
| SW Logistics Ltd | Transport & logistics | 2022 |
| SW Power & Contracting Services Limited | Construction | 2018 |
| SW Staffing Solutions Limited | Administrative & support | 2024 |
| Swales Collective Ltd | Information & communication | 2026 |
| Swan Lane Equestrian Centre Ltd | Education | 2019 |
| Swanland HR Limited | Professional & scientific | 2024 |
| Swanlink Technology Limited | Wholesale & retail | 1999 |
| Swann Graphics Ltd | Professional & scientific | 2018 |
| Swapnull Studios Ltd | Extraterritorial | 2017 |
| Sweet DEW Food Ltd | Wholesale & retail | 2024 |
| Sweeties Limited | Wholesale & retail | 2015 |
| Swift Car Parts Limited | Wholesale & retail | 2021 |
| Swift Car Recoveries Ltd | Transport & logistics | 2025 |
| Swift Fulfillment Ltd | Wholesale & retail | 2026 |
| Swift Improvements Ltd | Construction | 2018 |
| Swift Media Solutions Limited | Manufacturing | 1970 |
| Swift Parcels WY Ltd | Transport & logistics | 2026 |
| Swift Property Ltd | Professional & scientific | 2024 |
| Swift Rentals Limited | Administrative & support | 2026 |
| Swift Teamwear Ltd | Wholesale & retail | 2021 |
| Swiftbridge Formation Limited | Professional & scientific | 2026 |
| Swiftcloud Ltd | Information & communication | 2012 |
| Swiftkeys Ltd | Real estate | 2025 |
| Swiftsearchuk Limited | Professional & scientific | 2014 |
| Swim Boutique LLP | | 2010 |
| Swimbarn (Cheshire) Limited | Education | 2023 |
| Swimnation Ltd | Arts & recreation | 2025 |
| Swiped Swan Ltd | Hospitality | 2025 |
| Swish Services Ltd | Wholesale & retail | 2017 |
| Swiss Watch Group Ltd | Wholesale & retail | 2020 |
| Switch & Save Energy Ltd | Professional & scientific | 2023 |
| Swot AZ Ltd | Professional & scientific | 2014 |
| SY Gibson Green Ltd | Construction | 2024 |
| Sybro Spinning Limited | Professional & scientific | 1979 |
| SYC Apartments Limited | Real estate | 2023 |
| SYC Holdings Ltd | Financial services | 2024 |
| SYC Investments Ltd | Real estate | 2017 |
| Sycamore 1 Ltd | Construction | 2025 |
| Sycamore 2 Ltd | Construction | 2026 |
| Sycamore 3 Ltd | Construction | 2026 |
| Sycamore Homes and Construction Limited | Construction | 2024 |
| Sycamore Tree Care Limited | Public administration | 2020 |
| Sydor Holdings Limited | Manufacturing | 2014 |
| Sydor Technologies Limited | Manufacturing | 2014 |
| Syed Ecommerce Solutions Ltd | Wholesale & retail | 2023 |
| Syed Healthcare Ltd | Professional & scientific | 2021 |
| SYG Registry Ltd | Wholesale & retail | 2026 |
| Syjtl Limited | Extraterritorial | 2021 |
| Sykes & Dyson,Limited | Manufacturing | 1935 |
| Sykes Electrical Contractors Limited | Wholesale & retail | 2015 |
| Sykes Sites Ltd | Households | 2025 |
| Sylls (UK) Ltd | Professional & scientific | 2022 |
| Symbiotic Consultancy Ltd | Administrative & support | 2023 |
| Symmetry Environmental Limited | Professional & scientific | 2010 |
| Symmetry Law Limited | Professional & scientific | 2010 |
| Sympolic Limited | Wholesale & retail | 2025 |
| Synapse Cable Jointing Ltd | Construction | 2017 |
| Synaptic Software Limited | Administrative & support | 1995 |
| Synapze Medical Limited | Health & social care | 2022 |
| Sync Accountants Limited | Professional & scientific | 2022 |
| Syncd Design Limited | Information & communication | 2011 |
| Synergetics Health Limited | Wholesale & retail | 2024 |
| Synergos Consultancy Limited | Professional & scientific | 2014 |
| Synergy Health Recruitment Ltd | Extraterritorial | 2011 |