| Stormwood Interiors Limited | Manufacturing | 2019 |
| Storth House CIC | Education | 2013 |
| Stoves Direct Limited | Extraterritorial | 2010 |
| Strada Auto Sales Ltd | Wholesale & retail | 2024 |
| Strada Auto Valeting & Detailing Ltd | Administrative & support | 2023 |
| Straight Forward Funding Limited | Professional & scientific | 2019 |
| Strategic Projects UK Ltd | | 2008 |
| Strategy to Succeed Limited | Professional & scientific | 2010 |
| Stratline Ltd | Information & communication | 2025 |
| Stray FM Limited | Extraterritorial | 2022 |
| Streamline Transport Limited | Transport & logistics | 2021 |
| Street Clean Limited | Administrative & support | 2021 |
| Streetbikes | Arts & recreation | 2012 |
| Streetly Investment Limited | Real estate | 2019 |
| Streetwise Publications Limited | Information & communication | 1995 |
| Strength in Motion Physiotherapy Ltd | Health & social care | 2025 |
| Stretch ADV Ltd | Professional & scientific | 2024 |
| Stretchaboo Ltd | Manufacturing | 2026 |
| Stride Consultants Limited | Administrative & support | 2015 |
| Stringent Software Limited | Information & communication | 2007 |
| Stringer Brothers Upholstery Ltd | Manufacturing | 2020 |
| Strive Alternative Provision CIC | Education | 2025 |
| Strong Leadership Limited | Professional & scientific | 2023 |
| Strongbow Home Improvements Ltd | Construction | 2020 |
| Strongbow Windows Ltd | Manufacturing | 2026 |
| Stronsa Road Management Limited | Households | 2019 |
| Strut the PUP Dog Walking Ltd | Other services | 2022 |
| Stuart Spencer Consulting Ltd | Information & communication | 2012 |
| Stubblehead Ltd | Wholesale & retail | 2018 |
| Stuck in the Riddle Ltd | Arts & recreation | 2017 |
| Student Homes by Simple Ltd | Real estate | 2018 |
| Students Call Limited | Information & communication | 2015 |
| Studio 1 Skills & Craft Hub CIC | Education | 2023 |
| Studio 18 Hair and Beauty Ltd | Other services | 2014 |
| Studio 413 Limited | Professional & scientific | 2020 |
| Studio AMB Ltd | Manufacturing | 2026 |
| Studio Crusade Limited | Professional & scientific | 2022 |
| Studio EL Ltd | Professional & scientific | 2026 |
| Studio for Co-Operation CIC | Arts & recreation | 2009 |
| Studio Jack Shaw Ltd | Professional & scientific | 2026 |
| Studio S2 Architects Ltd | Professional & scientific | 2025 |
| STUDIO1996 Ltd | Wholesale & retail | 2024 |
| Studley Royal Sporting Ltd | Arts & recreation | 2021 |
| Study International Consultants Ltd | Wholesale & retail | 2025 |
| Studybit Consultancy Ltd | Education | 2025 |
| Stuffedcrust Ltd | Hospitality | 2023 |
| Stuffli Ltd | Wholesale & retail | 2025 |
| Stuvie ROS Ltd | Professional & scientific | 2025 |
| Styk Ltd | Real estate | 2017 |
| Styk+Dyk Limited | Professional & scientific | 2019 |
| Style by Juvi Ltd | Wholesale & retail | 2025 |
| Style Furniture (North) Ltd | Manufacturing | 2025 |
| Style With Swish Ltd | Wholesale & retail | 2021 |
| Stylio Nest Ltd | Wholesale & retail | 2025 |
| SU Pharma Limited | Wholesale & retail | 2023 |
| SUB290997 Ltd | Hospitality | 2025 |
| Subbiah Limited | Wholesale & retail | 2022 |
| Subhan Catering Services Ltd | Hospitality | 2024 |
| Subhani Traders Ltd | Manufacturing | 2023 |
| SUBS2GO Limited | Wholesale & retail | 2005 |
| Success Financial Limited | Wholesale & retail | 2019 |
| Sudil Properties Limited | Real estate | 1942 |
| Suedwolle Group UK Limited | Administrative & support | 2017 |
| SUF Homes Ltd | Real estate | 2025 |
| Sufarian Global Ltd | Wholesale & retail | 2026 |
| Suffolk Interior Solutions Limited | Wholesale & retail | 2025 |
| Sufiyan Khan Delivery Ltd | Transport & logistics | 2026 |
| Sugar & Dough Ltd | Hospitality | 2025 |
| Sugar & Swirls Ltd | Manufacturing | 2026 |
| Suitably Sporty Ltd | Wholesale & retail | 2017 |
| Suitcoin Ltd | Information & communication | 2024 |
| Suki-Bella Pet Care Limited | Other services | 2024 |
| Sukun Ltd | Wholesale & retail | 2023 |
| Sultan Travel HFD Ltd | Transport & logistics | 2024 |
| Sumfo Textile Limited | Wholesale & retail | 2021 |
| Summers Properties Limited | Real estate | 1997 |
| Summerwise Limited | Real estate | 1977 |
| Summit Automotive Huddersfield Ltd | Wholesale & retail | 2024 |
| Summit Automotive Servicing and Repairs Ltd | Wholesale & retail | 2026 |
| Summit Group (Yorkshire) Ltd | Financial services | 2026 |
| Summit Motor Co (Yorkshire) Ltd | Wholesale & retail | 2025 |
| Summit Trade Cars Ltd | Wholesale & retail | 2025 |
| Summit Transport (Yorkshire ) Ltd | Transport & logistics | 2026 |
| Sunbridge Holdings Limited | Construction | 2020 |
| Sunda Optometry Services Ltd | Other services | 2017 |
| Sundrops Limited | Manufacturing | 1938 |
| Sunfine Management Limited | | 1992 |
| Sunflowers Ltd | Wholesale & retail | 2026 |
| Sunlight Real Estate Ltd | Real estate | 2021 |
| Sunlight Transport (UK) Ltd | Transport & logistics | 2019 |
| Sunnacure Ltd | Health & social care | 2025 |
| Sunnapharma Ltd | Wholesale & retail | 2025 |
| Sunner Property Development Limited | Construction | 2025 |
| Sunnybutton Limited | Construction | 2003 |
| Sunsco Beauty Shop Limited | Wholesale & retail | 2024 |
| Sunshine & LIV Limited | Health & social care | 2020 |
| Sunshine Collection Ltd | Wholesale & retail | 2022 |
| Sunshine Group of Enterprises Ltd | Wholesale & retail | 2024 |
| Super Quality Trading Ltd | Wholesale & retail | 2021 |
| Super Shine Hand Car-Wash Ltd | Administrative & support | 2022 |