| Space and Thyme Management Limited | Hospitality | 2018 |
| Space Doctors Limited | Professional & scientific | 2001 |
| Space Drywall Ltd | Construction | 2022 |
| Space of OUR Own Ltd | Wholesale & retail | 2024 |
| Space Planning UK Ltd | Professional & scientific | 2004 |
| Space Worldwide Limited | Professional & scientific | 1997 |
| Spaceart International Ltd | Wholesale & retail | 2024 |
| Spacedcard Ltd | Information & communication | 2026 |
| Spaces by Kerry Sharp Limited | Professional & scientific | 2021 |
| Spacetech International Limited | Administrative & support | 2021 |
| Spacific Way Ltd | Information & communication | 2019 |
| Sparq Promotions Limited | Administrative & support | 2013 |
| Spartan Building Group Ltd | Construction | 2019 |
| SPC Energy Ltd | Financial services | 2026 |
| SPD (Brighton) Ltd | Water & waste | 2001 |
| Speaking Works Ltd | Education | 2012 |
| Spearwood Limited | Real estate | 2023 |
| Special Arts Services Limited | Manufacturing | 2006 |
| Special Risks Ltd | Financial services | 2004 |
| Specialist Policing Detention Solutions Limited | Administrative & support | 2026 |
| Spectacle Event Bars Limited | Hospitality | 2018 |
| Speechless Media Limited | Information & communication | 2017 |
| Speedshopvpn Limited | Information & communication | 2025 |
| Speedwell Building Limited | Households | 2003 |
| Spencer & Leigh Limited | Real estate | 2003 |
| Spencer's Roofing Services Limited | Construction | 2022 |
| SPF Thirty Acres Limited | Energy | 2015 |
| Spi&Ce Intimates Ltd | Wholesale & retail | 2021 |
| Spice Merchants Takeaway Limited | Hospitality | 2026 |
| Spice Tandoori Limited | Hospitality | 2019 |
| Spicy Bestie Ltd | Manufacturing | 2025 |
| Spider on the Wall Limited | Professional & scientific | 2007 |
| Spike Associates Ltd | Administrative & support | 2014 |
| Spike Marketing Ltd | Professional & scientific | 2009 |
| Spiller Trade Ltd | Wholesale & retail | 2015 |
| Spin UP Ltd | Information & communication | 2018 |
| Spirit Service Ltd | Information & communication | 2013 |
| Spirit Tape Records Ltd | Wholesale & retail | 2025 |
| Spitfire Print Solutions Ltd | Information & communication | 2013 |
| SPL Accountancy Services Ltd | Financial services | 2017 |
| Splinter Capital Ltd | Information & communication | 2023 |
| Spor-T Learning Ltd | Education | 2025 |
| Sports Group International UK Limited | Education | 2022 |
| Sports Horizon Ltd | Professional & scientific | 2018 |
| Sports Secure Ltd | Financial services | 2022 |
| Sportsline Productions Limited | Information & communication | 2013 |
| Sportuccino Limited | Information & communication | 2016 |
| Spotless Shine Cleaning Solutions Ltd | Administrative & support | 2024 |
| Spotted Orange Limited | Professional & scientific | 2013 |
| Spratt's Complex Management Limited | Real estate | 2016 |
| Spresso Limited | Hospitality | 2025 |
| Spring Meadow Uckfield Management Limited | Hospitality | 2023 |
| Springbird Sussex Limited | Construction | 2024 |
| Spro Coffee Co Ltd | Wholesale & retail | 2024 |
| Sproq Limited | Information & communication | 2025 |
| Sproston Green Consulting Limited | Professional & scientific | 2025 |
| Spurpoint Limited | Construction | 1979 |
| SPV 1023J Ltd | Real estate | 2005 |
| SPV 1157182 Ltd | Administrative & support | 2012 |
| SPV 1157G Ltd | Construction | 2009 |
| SQS Projects Ltd. | Professional & scientific | 2010 |
| Srai Dental Ltd | Health & social care | 2025 |
| SRC Corporate Finance Ltd | Extraterritorial | 2018 |
| SRL AR Ltd | Information & communication | 2020 |
| Srtax Accountants Limited | Professional & scientific | 2014 |
| SRW Resources Limited | Professional & scientific | 2023 |
| SS Care Consultancy Services Ltd | Administrative & support | 2012 |
| SS Ecom Ltd | Administrative & support | 2023 |
| SS Secretariat Limited | Professional & scientific | 2000 |
| SSB Dental Limited | Health & social care | 2020 |
| SSD Safety Ltd | Administrative & support | 2008 |
| Sseb Properties Ltd | Real estate | 2024 |
| SSM Anaesthesia Limited | Health & social care | 2026 |
| SSV Yoga Ltd | Arts & recreation | 2022 |
| ST Bishoy Limited | Real estate | 2026 |
| ST Catherine's Property Limited | Real estate | 2020 |
| ST George Commercial Finance Brokers Ltd | Financial services | 2014 |
| ST George Foreign Exchange Limited | Professional & scientific | 2023 |
| ST George Insurance Brokers Limited | Financial services | 2010 |
| ST George Property Assets Limited | Real estate | 2009 |
| ST George's Global Services Ltd | Wholesale & retail | 2020 |
| ST Gosefkiromaria Limited | Transport & logistics | 2023 |
| ST Karas Ltd | Wholesale & retail | 2016 |
| ST Kilda Properties Limited | Administrative & support | 2013 |
| ST Leonard's AVE Holding Ltd | Financial services | 2026 |
| ST Leonards AVE Property Limited | Households | 2026 |
| ST Lukes Court Limited | Households | 2007 |
| ST Mary Store BTN Ltd. | Administrative & support | 2012 |
| ST Michael Investments Ltd | Real estate | 2024 |
| ST Mina & ST George Global Services Ltd | Wholesale & retail | 2025 |
| ST Noha Properties Ltd | Real estate | 2018 |
| ST Philopater S&M Ltd | Wholesale & retail | 2017 |
| ST Piran Dental Practice Ltd | Health & social care | 2007 |
| ST Raphael Convenience Ltd | Wholesale & retail | 2021 |
| ST Wannas Limited | Wholesale & retail | 2017 |
| ST. Aubyn's (Hove) Management Limited | Households | 1977 |
| ST. Bridget's Mead Limited | Households | 1989 |
| ST. Catherine's Residents Company (Hove) Limited | Administrative & support | 1980 |
| ST. George Financial Consultants Limited | Financial services | 2004 |
| ST. George's Finance Limited | | 1988 |