| Sockets 2 Solar Ltd | Construction | 2023 |
| Socotra Ltd | Administrative & support | 2023 |
| Sofi's Coffeehouse Ltd | Hospitality | 2025 |
| Softopia Ltd | Information & communication | 2012 |
| Solar Fire Services Limited | Professional & scientific | 2014 |
| Solar Woodwalton Ltd | Energy | 2013 |
| Solarcore Power Ltd | Financial services | 2025 |
| Solargize Frontier Materials Ltd | Manufacturing | 2018 |
| Solelektric Ltd | Energy | 2022 |
| Solent Air Limited | Arts & recreation | 1986 |
| Solent Ribs Ltd | Manufacturing | 2021 |
| Solindan Ltd | Professional & scientific | 2010 |
| Solo Bars Ltd | Hospitality | 2024 |
| Solobirch Ltd | Professional & scientific | 2025 |
| Solow Car Transport Ltd | Transport & logistics | 2025 |
| Solts Ltd | Wholesale & retail | 2026 |
| Solution Products Ltd | Manufacturing | 2025 |
| Solveituk Ltd | Information & communication | 2018 |
| Solvex Solutions Limited | Professional & scientific | 2006 |
| Solvo Limited | Professional & scientific | 2014 |
| Solyd Trading Limited | Wholesale & retail | 2025 |
| Something Recordings Ltd | Information & communication | 2022 |
| Sonic Box Studios Limited | Construction | 2022 |
| Sonic Screwdriver Ltd | Manufacturing | 2010 |
| Sonic Studio Ltd | Information & communication | 2024 |
| Sonicon Music Ltd. | Arts & recreation | 2017 |
| Sono Pro Ltd | Health & social care | 2018 |
| Sonograto Limited | Hospitality | 2019 |
| Sophie Carter Optical Ltd | Administrative & support | 2024 |
| Sophie Taylor-West Limited | Wholesale & retail | 2017 |
| Sophie Travel Ltd | Extraterritorial | 2017 |
| Sophion Technology Limited | Professional & scientific | 2026 |
| Sora Electrical Services Ltd | Construction | 2025 |
| Soracte Ltd | Professional & scientific | 2022 |
| Sorela-Martin Property Holdings Ltd | Real estate | 2023 |
| Sorela-Martin Property Management Ltd | Real estate | 2023 |
| Sorlings Reach RTM Company Limited | Real estate | 2024 |
| Sorted & Supported by Kirsti COX Advocacy CIC | Education | 2026 |
| Sosauna Ltd | Other services | 2025 |
| Soso Swim Limited | Wholesale & retail | 2021 |
| Sosorin Construction Limited | Construction | 2020 |
| Sosteneo Bess 1 (UK) Limited | Energy | 2022 |
| Sosteneo Bess 2 (UK) Limited | Energy | 2022 |
| Soteer Limited | Extraterritorial | 2016 |
| Soul Work Studios Ltd | Arts & recreation | 2026 |
| Soulful Journeys (Travel) Limited | Administrative & support | 2025 |
| Soundhouse Builders Limited | Construction | 2022 |
| Soundhouse Loft Company Ltd | Construction | 2012 |
| Soundhouse UK Limited | Construction | 2002 |
| Soundwerks Ltd | Information & communication | 2025 |
| Soundwerks Voices CIC | Information & communication | 2025 |
| Sourcing Cars UK Limited | Wholesale & retail | 2021 |
| South Coast Accountancy Services Limited | Professional & scientific | 2014 |
| South Coast Connections Ltd | Construction | 2026 |
| South Coast Food Collective Catering Ltd | Hospitality | 2026 |
| South Coast Food Collective Ltd | Hospitality | 2025 |
| South Coast Inns Ltd | Administrative & support | 2016 |
| South Coast Metal Roofing Ltd | Administrative & support | 2014 |
| South Coast Recruitment Ltd | Administrative & support | 2026 |
| South Coastal Consultants Ltd | Professional & scientific | 2026 |
| South Downs Electrical Limited | Construction | 2016 |
| South Downs Safety Ltd | Professional & scientific | 2012 |
| South East Property Surveyors Ltd | Professional & scientific | 2026 |
| South East Surveyors Ltd | Professional & scientific | 2021 |
| South England Exchange Limited | Education | 2015 |
| Southcliffe Residents Association Limited | Households | 1992 |
| Southdown Home & Leisure Ltd | Wholesale & retail | 2020 |
| Southdown Motor Services Limited | Transport & logistics | 2022 |
| Southdown Psychology Ltd | Health & social care | 2023 |
| Southdowns Park Limited | Construction | 2015 |
| Southern African Social Policy Research Insights | Professional & scientific | 2012 |
| Southern Artisan Investment Ltd | Real estate | 2024 |
| Southern Artisan Ltd | Construction | 2011 |
| Southern Book Keeping Services Limited | Administrative & support | 2021 |
| Southern Counties Events Ltd | Extraterritorial | 2013 |
| Southern Damp Proofing Ltd | Construction | 2019 |
| Southern Drywall Interiors Ltd | Construction | 2010 |
| Southern Hospice Group Home Care Ltd | Health & social care | 2007 |
| Southern News and Pictures Ltd | Professional & scientific | 2003 |
| Southern Primecare (Brighton) Limited | Health & social care | 2009 |
| Southern Properties (Sussex) Ltd | Real estate | 2015 |
| Southern Property Renovations Ltd | Construction | 2014 |
| Southern Sale Signs Limited | Administrative & support | 2009 |
| Southern Sky Technology Limited | Information & communication | 2014 |
| Southern Technology IT and Computer Services Limited | Information & communication | 2007 |
| Southernpathways Ltd | Information & communication | 2025 |
| Southon Consulting Limited | Professional & scientific | 2015 |
| Southpoint Music Limited | Information & communication | 2016 |
| Southpoint Music Management Limited | Arts & recreation | 2025 |
| Southside Removals Ltd | Wholesale & retail | 2025 |
| Southview Court Southwick Ltd | Households | 2021 |
| Sovereign Sales Ltd | Professional & scientific | 2024 |
| Sovereign Services Leeds Ltd | Administrative & support | 2021 |
| SP Eight Abercromby Limited | Real estate | 2022 |
| SP Eight Cherrywood Limited | Real estate | 2020 |
| SP Eight Real Estate Limited | Real estate | 2020 |
| SP UK Investment Limited | Real estate | 2016 |
| Space Agent Lewes Limited | Administrative & support | 2023 |
| Space and Thyme Kitchens Limited | Hospitality | 2018 |
| Space and Thyme Limited | Hospitality | 2016 |