| Sase Boutique Ltd | Wholesale & retail | 2022 |
| SAT Sanghera Ltd | Information & communication | 2013 |
| Sauaza Management Ltd | Real estate | 2021 |
| Saurida UK Ltd | Wholesale & retail | 2018 |
| Savmore Holding Limited | Wholesale & retail | 2026 |
| Savvy Build Limited | Information & communication | 2025 |
| SAY NO to Employment Ltd | Professional & scientific | 2025 |
| SB Consulting (UK) Limited | Professional & scientific | 2007 |
| SB Motorsport Limited | Professional & scientific | 2014 |
| SB Speech and Language Therapy Ltd | Health & social care | 2020 |
| SBK Ventures Ltd | Real estate | 2024 |
| Sbksb Ltd | Wholesale & retail | 2021 |
| SBM Legal Ltd | Professional & scientific | 2024 |
| SBM Performance Limited | Wholesale & retail | 2017 |
| Sc&Dl Contracts Ltd | Construction | 2023 |
| Scaffgap Limited | Construction | 2009 |
| Scala Finance Limited | Professional & scientific | 2025 |
| Scarborough Technical Services Limited | Professional & scientific | 2012 |
| Scern Limited | Information & communication | 2023 |
| SCHOLAR2SCHOLAR Ltd | Education | 2024 |
| School of Strategic Studies Ltd | Education | 2020 |
| Sciber Ltd | Professional & scientific | 2025 |
| Scolec Group Ltd | Construction | 2025 |
| Scotsman Building Services Ltd | Construction | 2025 |
| Scotsman Properties Limited | Real estate | 2025 |
| Scott Blinds Ltd | Construction | 2021 |
| Scott Shelton & SON Limited | Administrative & support | 2024 |
| Scott Taylor Flooring Limited | Construction | 2015 |
| Scotts Group Construction Ltd | Construction | 2026 |
| Scroll Stop Limited | Other services | 2025 |
| SD Property Mgmt Limited | Real estate | 2024 |
| SDL Pro Limited | Other services | 2023 |
| SDR Financial Services Ltd | Other services | 2019 |
| SDS Alloys Limited | Wholesale & retail | 2018 |
| SDS Facades Limited | Construction | 2020 |
| SDS Schulze Ltd | Administrative & support | 2026 |
| SDT Lifting Ltd | Construction | 2018 |
| SE Leads Limited | Administrative & support | 2014 |
| Seabaha Ltd | Wholesale & retail | 2021 |
| Seagull Freight Services Ltd | Transport & logistics | 2013 |
| SEB Telecoms Ltd | Information & communication | 2024 |
| Sebwin Properties Ltd | Real estate | 2022 |
| Security & Fire Solutions Limited | Administrative & support | 2007 |
| Security Masters Limited | Administrative & support | 2001 |
| Security Shutters Limited | Manufacturing | 1999 |
| Sedcom Networks Ltd | Information & communication | 2003 |
| Seddon Property Ltd | Real estate | 2025 |
| SEE IT BE IT Films Ltd | Information & communication | 2021 |
| Seed Maritime UK Limited | Professional & scientific | 2017 |
| Seeside UK Limited | Information & communication | 2020 |
| Sega Group Limited | Construction | 2026 |
| SEK Consulting Limited | Information & communication | 2014 |
| Selak Limited | Hospitality | 2018 |
| Select Bathrooms Essex Limited | Wholesale & retail | 2025 |
| Select Developments Essex Limited | Construction | 2026 |
| Select Plumbing Essex Limited | Wholesale & retail | 2012 |
| Selectatreat Ltd | Wholesale & retail | 2026 |
| Selmun Limited | Real estate | 2024 |
| SEM & Construction Ltd | Construction | 2024 |
| SEN Property Law Ltd | Professional & scientific | 2024 |
| Senalcy Limited | Hospitality | 2026 |
| Sences Capital Ltd | Real estate | 2025 |
| Septagon Limited | Health & social care | 2018 |
| Seraneq Limited | Administrative & support | 2017 |
| Serenity Care Support Services Ltd | Health & social care | 2025 |
| Sersens Food and Grocery Limited | Wholesale & retail | 2025 |
| Serzin Limited | Construction | 2023 |
| Setl Legal Limited | Professional & scientific | 2026 |
| Setola Health Care Limited | Health & social care | 2015 |
| Setsoft Limited | Information & communication | 2001 |
| Seven Construction and Interiors Ltd | Professional & scientific | 2014 |
| Sevenstrategicconsultants Ltd | Information & communication | 2026 |
| SFD Property Holdings Ltd | Real estate | 2025 |
| SG Brewing Co. Limited | Manufacturing | 2024 |
| SG Cardiac Services Ltd | Education | 2020 |
| SG Osteo Limited | Other services | 2014 |
| SG Properties & Development Ltd | Real estate | 2024 |
| SGA Project Management Limited | Professional & scientific | 2023 |
| SGE Properties Limited | Real estate | 2018 |
| Sgott Ltd | Construction | 2018 |
| SGS Scenery Garden Supplies Ltd | Wholesale & retail | 2023 |
| SGT Property Limited | Real estate | 2017 |
| SH Autos Limited | Wholesale & retail | 2015 |
| SH Management Solutions Ltd | Professional & scientific | 2024 |
| Sh&Ld Rendering Ltd | Construction | 2014 |
| Shad Builders Ltd | Construction | 2025 |
| Shades by GC Limited | Real estate | 2025 |
| Shads Construction Ltd | Construction | 2022 |
| Shads Security Ltd | Administrative & support | 2026 |
| Shah Private Car Ltd | Information & communication | 2025 |
| Shahzad Collections Limited | Wholesale & retail | 2018 |
| Shahzad Kitchen Limited | Hospitality | 2020 |
| Shahzad Properties Limited | Real estate | 2020 |
| Shamshad-Nar Limited | Hospitality | 2025 |
| Shan Airs Ltd | Professional & scientific | 2023 |
| Shane Parker Ltd | Information & communication | 2019 |
| Shanie Accountancy Ltd | Professional & scientific | 2024 |
| Shape Builder Ltd | Construction | 2026 |
| Sharon to Limited | Other services | 2014 |
| Sharpebusiness Ltd | Administrative & support | 2015 |