| Rain Nutrience Holding Limited | Financial services | 2019 |
| Rain Nutrience Ltd | Manufacturing | 2004 |
| Rain Storm (Honiton) Limited | Real estate | 2015 |
| Rainbow Disks Ltd | Information & communication | 2006 |
| Rainuk Property Limited | Financial services | 2023 |
| Ramer Limited | Manufacturing | 1949 |
| RBS Property Investments Limited | Real estate | 2023 |
| Rc-Build Developments Ltd | Real estate | 2024 |
| Rc-Builders Ltd | Construction | 2024 |
| RDA Insulation Ltd | Construction | 2007 |
| Rebalance Injury Clinic Exeter Ltd | Arts & recreation | 2019 |
| Rebalance Injury Clinic Honiton Limited | Other services | 2024 |
| Rebalance Injury Clinic Ilminster Ltd | Arts & recreation | 2025 |
| Rebecca Anne Designs Ltd | Manufacturing | 2023 |
| Red Homes Estate Agents Limited | Real estate | 2005 |
| Red Homes Limited | Real estate | 2005 |
| Redcotec LLP | | 2010 |
| Redfield Homes Group Ltd | Financial services | 2023 |
| Redfield Housing Ltd | Real estate | 2023 |
| Redfield Property Developments Limited | Construction | 2020 |
| Regalo Limited | Wholesale & retail | 2013 |
| Release Southwest Community Interest Company | Health & social care | 2013 |
| Resitec Residential Technologies Limited | Extraterritorial | 2012 |
| Resoluteons Ltd | Administrative & support | 2022 |
| Reverberate Public Relations Limited | Professional & scientific | 2007 |
| Reynolds Assessment Services Ltd | Other services | 2022 |
| RG Dent Ltd | Health & social care | 2015 |
| Rhdc Services Ltd | Administrative & support | 2007 |
| Ridge Roofing Limited | Construction | 2010 |
| Ridge Scaffolding Services Limited | Construction | 2012 |
| Ringsports Promotions Limited | Arts & recreation | 2014 |
| Rivers of Health Limited | Health & social care | 2003 |
| Rnra PUB Company Ltd | Hospitality | 2021 |
| Robert J. Tyers Limited | Construction | 2002 |
| Robinson Associates Construction Services Ltd | Construction | 2019 |
| Robottik Ltd | Information & communication | 2026 |
| Robson Accountants Ltd | Professional & scientific | 2024 |
| Robson Financial Limited | Financial services | 2012 |
| Robson Lettings Limited | Real estate | 2020 |
| Robson Tax and Accountancy Services Limited | Professional & scientific | 2018 |
| ROC Property Ltd | Real estate | 2006 |
| Rochesters Hire Ltd | Administrative & support | 2014 |
| Roman Way Management Co (2006) Limited | Households | 2006 |
| Rosie Parsons Photography Ltd | Professional & scientific | 2021 |
| Roughwood Consulting Limited | Professional & scientific | 2014 |
| Royal Oak Farm Ltd | Agriculture & fishing | 2023 |
| Rozo Consulting Limited | Real estate | 2020 |
| RTR Developments Ltd | Construction | 2025 |
| Ruby Red Running C.I.C. | Wholesale & retail | 2022 |
| Russell Brown Consultancy Ltd | Professional & scientific | 2021 |
| Ryecroft Holdings Group Limited | Other services | 2025 |
| S & H SW Construction Ltd | Construction | 2026 |
| S & T Spray Ltd | Wholesale & retail | 2012 |
| S a Boland Limited | Construction | 2003 |
| S E Auto Engineers Limited | Professional & scientific | 2010 |
| S Eldridge Design Limited | Professional & scientific | 2013 |
| S Macgregor Services Limited | Other services | 2023 |
| S W Truck Services Limited | Wholesale & retail | 2021 |
| S.W. Taverns Limited | Hospitality | 2023 |
| Said Risk Management Consultants Limited | Professional & scientific | 2017 |
| Sales Geek Exeter Ltd | Professional & scientific | 2025 |
| Salston Manor Ltd | Households | 2022 |
| Salty Padel Ltd | Administrative & support | 2025 |
| Sanctum by Sophie Ltd | Other services | 2025 |
| Sarah Critchell Limited | Other services | 2018 |
| Sargent and Tribe Ltd | Real estate | 2020 |
| Sasha Watts Decorating Contractors Ltd | Construction | 2025 |
| Save a Surface Ltd | Construction | 2026 |
| SB Bray Properties Ltd | Real estate | 2023 |
| SC Group-Global Limited | Professional & scientific | 2012 |
| SC Innovation-Global Limited | Manufacturing | 2012 |
| Scavenger Ltd | Wholesale & retail | 2026 |
| Scott & Willis Ltd | Administrative & support | 2011 |
| Scott Lazenby Plumbing & Heating Ltd | Construction | 2019 |
| Scribblebox Emporium LLP | | 2022 |
| Seasky Productions Limited | Professional & scientific | 2016 |
| Sebic Group Ltd | Financial services | 2022 |
| Secura Obscura Limited | Professional & scientific | 2012 |
| Securefire Ltd | Administrative & support | 2016 |
| Select Property Solutions (SW) Ltd | Real estate | 2018 |
| Select Windows (Honiton) Limited | Construction | 2008 |
| Selextorhood CIC | Professional & scientific | 2021 |
| Sell Your Service Limited | Information & communication | 2015 |
| Setpoint Solutions Ltd | Construction | 2017 |
| Sharper Print and Mail Ltd | Manufacturing | 2017 |
| Shawlands Properties (Oxford) Ltd | Real estate | 2016 |
| Sheerspeed Limited | Extraterritorial | 2007 |
| Sheerspeed Shelters Limited | Manufacturing | 1998 |
| Sidmouth Community Carnival Ltd | Arts & recreation | 2022 |
| Sidmouth Jazz and Blues Festival Ltd | Arts & recreation | 2021 |
| Sidmouth Scaffolding (S.W.) Limited | Construction | 1999 |
| Sidmouth Tech Ltd | Information & communication | 2024 |
| Silver Reset Limited | Information & communication | 2025 |
| Simon a Martin Limited | Professional & scientific | 2016 |
| Simplifymyhousesale Ltd | Information & communication | 2022 |
| Sitevend SW Limited | Wholesale & retail | 2024 |
| Sixtyfour Ltd | Real estate | 2007 |
| SJT Management Services Ltd | Professional & scientific | 2019 |
| Sky Plant Limited | Extraterritorial | 1980 |
| Skydive Buzz Limited | Arts & recreation | 1999 |