| Skydive Dunkeswell Limited | Transport & logistics | 2025 |
| Skydive South West Limited | Arts & recreation | 2025 |
| Slade Properties (SW) Limited | Construction | 2013 |
| Smart Retrofit Limited | Professional & scientific | 2025 |
| Smarter Print Ltd | Manufacturing | 2025 |
| Snodwell Farm Limited | Hospitality | 2017 |
| Soft Options Honiton Limited | Wholesale & retail | 2012 |
| Software Technical Management Limited | Information & communication | 2001 |
| Sophie Mess Ltd | Arts & recreation | 2026 |
| South Coast Services Group Limited | Wholesale & retail | 2025 |
| South West Airfields Heritage Ltd | Arts & recreation | 2004 |
| South West Estate Maintenance Ltd | Construction | 2025 |
| South West Growth Service Limited | Professional & scientific | 2016 |
| South West OIL Tanks Limited | Construction | 2019 |
| Southleigh Spice Ltd | Hospitality | 2025 |
| Southwest Home Improvements Ltd | Construction | 2019 |
| Sovereign Fields (Bracknell H16) Management Company Limited | Households | 2010 |
| Sozo Silver Ltd | Manufacturing | 2022 |
| Sparkle N Shine Ltd | Administrative & support | 2017 |
| Sparkys Taxis Limited | Other services | 2013 |
| Spence Cross Consulting Limited | Professional & scientific | 2019 |
| Spencer & Bates Ltd | Manufacturing | 2022 |
| Sports Car Services (SW) Ltd | Wholesale & retail | 2011 |
| Spritehill Limited | Real estate | 1997 |
| Squeaky Queen Ltd | Administrative & support | 2022 |
| Squeaky Wheels Limited | Wholesale & retail | 2014 |
| SS & M Properties Limited | Real estate | 2013 |
| Sskl Limited | Construction | 2017 |
| SSQ Construction Ltd | Administrative & support | 2022 |
| SSQ Property Ltd | Real estate | 2023 |
| ST Just Management Company Limited | Households | 2002 |
| ST. Isidore Agriculture Ltd | Agriculture & fishing | 2015 |
| Staker Mclean Consulting Ltd | Professional & scientific | 2019 |
| Staplethorne Ltd | Wholesale & retail | 1996 |
| Stay K Accommodation Ltd | Hospitality | 2024 |
| Steadfast Property Development Ltd | Construction | 2022 |
| Stealth Brands Online Ltd | Wholesale & retail | 2024 |
| Stealth Enterprise Ltd | Financial services | 2016 |
| Steelbadger Consulting Limited | Professional & scientific | 2005 |
| Stellar Hospitality Group Ltd | Hospitality | 2025 |
| Stellar Restaurants (Canford) Ltd | Hospitality | 2026 |
| Stentwood Tea Room LLP | | 2024 |
| Stephen Lonsdale Limited | Real estate | 1995 |
| Stillmans (Devon) Limited | Wholesale & retail | 1998 |
| Stones Automatic Driving School Ltd | Education | 2025 |
| Stones Driving School Ltd | Education | 2025 |
| Strategic Development and Consulting Ltd | Professional & scientific | 2024 |
| Strawbridge Transport Limited | Transport & logistics | 2002 |
| Street Removals & Storage Ltd | Transport & logistics | 2023 |
| Stuart Guy-Mulley Limited | Professional & scientific | 1997 |
| Studio NO. 63 Ltd | Other services | 2022 |
| Super Tramp Bodmin Ltd | Arts & recreation | 2014 |
| Super Tramp Glasgow Limited | Extraterritorial | 2022 |
| Super Tramp Parks Ltd | Arts & recreation | 2021 |
| Super Tramp Roborough Limited | Arts & recreation | 2017 |
| Supervizen Ltd | Professional & scientific | 2024 |
| Suttonmill Limited | Construction | 2020 |
| SVA Motor Group Ltd | Wholesale & retail | 2025 |
| Swinton Court Management Co Ltd | Professional & scientific | 2005 |
| Synergi (SW) Limited | Construction | 2014 |
| T.W.S Property Development Ltd | Construction | 2026 |
| Tabity Limited | Professional & scientific | 2026 |
| Talking HRM Ltd | Information & communication | 2014 |
| Tamarisk Housing Supported Living Ltd | Health & social care | 2015 |
| Tango 1 Facilities Management Ltd | Administrative & support | 2025 |
| Tavi Dent Ltd | Health & social care | 2024 |
| TCS Japanese Imports Limited | Wholesale & retail | 2024 |
| TCS Service & MOT Ltd | Wholesale & retail | 2025 |
| Tech Comms Global Ltd | Information & communication | 2018 |
| Teixeira Dent Ltd | Health & social care | 2022 |
| Tera Networks Ltd | Information & communication | 2025 |
| Teucro Ltd | Professional & scientific | 2011 |
| Tewfour Limited | Professional & scientific | 2023 |
| THE Bank Taunton Limited | Hospitality | 2015 |
| THE Barns (Hedgend Barton) Management Limited | Households | 2003 |
| THE Brake Centre Limited | Manufacturing | 2019 |
| THE Brave Gurkhas Ltd | Hospitality | 2020 |
| THE Castle Gate Management Group Ltd | Administrative & support | 2024 |
| THE Change Emporium Limited | Professional & scientific | 2010 |
| THE Coach House (Upottery) Management Limited | Households | 1993 |
| THE Coastal Boutique (Devon) Limited | Wholesale & retail | 2023 |
| THE Conservatory & Window Factory Limited | Construction | 2014 |
| THE DEN Honiton C.I.C. | Hospitality | 2023 |
| THE Devon Fishmongers Ltd | Wholesale & retail | 2025 |
| THE Dorset Gardens Trust | Information & communication | 1990 |
| THE Drawing Office (SW) Ltd | Professional & scientific | 2012 |
| THE Eco Emporium Limited | Manufacturing | 2023 |
| THE Exeter Beauty Clinic Limited | Other services | 2018 |
| THE Fairway Finderz Ltd | Arts & recreation | 2025 |
| THE Gear Mill Ltd | Wholesale & retail | 2014 |
| THE Grille Shop Limited | Wholesale & retail | 2004 |
| THE Holt PUB Company Ltd | Hospitality | 2024 |
| THE House of Devon Limited | Wholesale & retail | 2026 |
| THE Hub Vintage Wholesale Limited | Wholesale & retail | 2022 |
| THE Inner Garden Limited | Wholesale & retail | 2008 |
| THE Landscape Builder Limited | Construction | 2026 |
| THE Landscape Studio Consulting (UK) Limited | Professional & scientific | 2025 |
| THE Natural Cabinet Company Ltd | Manufacturing | 2015 |
| THE Next Generation (CSM) Limited | Health & social care | 2017 |
| THE Old Mill Industries Ltd | Information & communication | 2014 |