| SPC Cars Ltd | Wholesale & retail | 2010 |
| SPC Electrical Ltd | Construction | 2022 |
| SPD Group Limited | Real estate | 2013 |
| SPD KSA Limited | Construction | 2026 |
| SPE Property Investments Limited | Real estate | 2015 |
| Specialist Fraud Investigations Training & Consultancy . Limited | Education | 2018 |
| Specialist Speech & Language Therapy Services Limited | Health & social care | 2015 |
| Speechsounddisorder Ltd | Transport & logistics | 2024 |
| Spencer Dean Properties Ltd | Real estate | 2025 |
| Spice Fusion Holmfirth Limited | Hospitality | 2021 |
| Spider Platform Hire Limited | Construction | 2025 |
| Spiraspaces Ltd | Hospitality | 2016 |
| Spirul Ltd | Administrative & support | 2006 |
| Springhead Farm Limited | Agriculture & fishing | 2026 |
| SPW Coaching Limited | Administrative & support | 2017 |
| SS and GS Property Ltd | Construction | 2016 |
| SS Groundworks (Derbyshire) Limited | Construction | 2015 |
| SSC Renewables Ltd | Energy | 2021 |
| ST George's Management Co (Scholes) Limited | Households | 2015 |
| Stacey Freeth Ltd | Health & social care | 2023 |
| Staff 365 Limited | Extraterritorial | 2014 |
| Stageability Ltd | Arts & recreation | 2025 |
| Stanley Park Farm Limited | Agriculture & fishing | 2022 |
| Stanley Park Promotions Ltd | Wholesale & retail | 2023 |
| Star Delta Power Ltd | Professional & scientific | 2018 |
| Star Delta Software Ltd | Information & communication | 2023 |
| STAR121 Limited | Professional & scientific | 2016 |
| Starlake Technology Ltd | Information & communication | 2020 |
| Stavelysr Limited | Other services | 2021 |
| Stead Robinson HGA Limited | Professional & scientific | 2018 |
| Stead Robinson Limited | Other services | 2003 |
| Stephen Lock Limited | Other services | 2025 |
| Stephenson Builders Yard Limited | Construction | 2025 |
| Stephenson Trees and Landscapes Limited | Administrative & support | 2014 |
| Steps to Holmfirth Limited | Wholesale & retail | 2018 |
| STF Wines Limited | Hospitality | 2024 |
| Stmco Ltd. | Construction | 1994 |
| Stone Oak Property Services Ltd | Real estate | 2022 |
| Stopdean Limited | Construction | 2000 |
| Stork Business Consulting Limited | Financial services | 2022 |
| Strafford Property Services Ltd | Real estate | 2021 |
| Straight Line Ventures Ltd | Wholesale & retail | 2022 |
| Strata Partners Ltd | Financial services | 2026 |
| Stratas Business Solutions LLP | | 2013 |
| Stratovant Ltd | Information & communication | 2018 |
| Stretto Creative Limited | Professional & scientific | 2010 |
| Structherm Limited | Construction | 1982 |
| STS Engineering Solutions Ltd | Administrative & support | 2018 |
| Studio Armitage Architects Limited | Professional & scientific | 2025 |
| Studio SK Ltd | Professional & scientific | 2025 |
| Submerged Sound Ltd | Information & communication | 2023 |
| SUE Barnes Properties Limited | Real estate | 2017 |
| Sugden Properties Huddersfield Ltd | Construction | 2025 |
| Summerside and Partners Ltd | Administrative & support | 2025 |
| Sun-Light Solutions Limited | Wholesale & retail | 2012 |
| Super Infinite Limited | Wholesale & retail | 2023 |
| Svr-Hd Limited | Wholesale & retail | 2026 |
| SW Interior Designs Ltd | Professional & scientific | 2012 |
| Swaine Investments Ltd | Real estate | 2023 |
| Swan Hunter Limited | Professional & scientific | 2024 |
| Swan Mill Management Company Limited | Professional & scientific | 2005 |
| Swift Accountancy (Holmfirth) Ltd | Professional & scientific | 2017 |
| Swim Play Academy Ltd | Arts & recreation | 2008 |
| Swimbabes Holdings Limited | Financial services | 2014 |
| Swiz PAK Limited | Wholesale & retail | 2012 |
| Swooshed Audio Visual Limited | Professional & scientific | 2018 |
| Swooshed Event Production Limited | Professional & scientific | 2018 |
| Swooshed Holdings Limited | Financial services | 2025 |
| Swooshed Limited | Professional & scientific | 2008 |
| Swosavsepli Limited | Financial services | 2025 |
| Sykes Farming Limited | Agriculture & fishing | 2017 |
| System 'H' Engineering Limited | Manufacturing | 1988 |
| Sytrax Systems Limited | Professional & scientific | 2026 |
| T & R Properties LLP | | 2001 |
| T J Pallets (Huddersfield) Limited | Manufacturing | 1999 |
| T&C Cleaning Ltd | Administrative & support | 2025 |
| T.S Property’S Solutions Limited | Construction | 2026 |
| Taozen Ltd | Health & social care | 2025 |
| TAP House (Yorkshire) Limited | Hospitality | 2015 |
| Tata Huddersfield Ltd | Real estate | 2011 |
| TAY Martin Consultants Ltd | Professional & scientific | 2023 |
| Taylormade Screen Covers Limited | Manufacturing | 2022 |
| Taylors Foodstore Limited | Wholesale & retail | 2012 |
| TB Removals & Storage Ltd | Transport & logistics | 2024 |
| TB Tractors & Plant Ltd | Manufacturing | 2023 |
| Tcdiabetes Limited | Health & social care | 2019 |
| Tdac Ltd | Education | 2023 |
| Tdmc Services Limited | Information & communication | 2011 |
| Team Ensign Limited | Administrative & support | 1999 |
| Team Luke Property Developments Ltd | Construction | 2025 |
| Team Spirit Promotions Limited | Manufacturing | 2003 |
| Tech & Time Limited | Wholesale & retail | 2025 |
| Tech Recruitment Solutions Ltd | Information & communication | 2017 |
| Techcellence Ltd | Professional & scientific | 2022 |
| Techvision AV Ltd | Manufacturing | 2020 |
| Teck Solutions Ltd | Information & communication | 2014 |
| Tecni-Build (Northern) Limited | Construction | 2004 |
| Tecnica Group Ltd | Wholesale & retail | 2025 |
| Telecom West Yorkshire Ltd | Information & communication | 2021 |
| Tellus Toolkit Limited | Professional & scientific | 2015 |