| SCHOSWEEN20 Limited | Extraterritorial | 2018 |
| SCHOSWEEN51 Limited | Extraterritorial | 2019 |
| SCM (Holdings) Limited | Financial services | 2012 |
| SCM Networks & Electrical Ltd | Construction | 2023 |
| SCM Rooftech Limited | Construction | 2009 |
| Scot Douglas Properties Ltd | Real estate | 2020 |
| Scotland & Co Business Services Limited | Professional & scientific | 2003 |
| Sculpture Lounge Ltd | Arts & recreation | 2020 |
| SD Ferguson Ltd | Arts & recreation | 2022 |
| SDS Joinery, Bathroom & Kitchens Ltd | Construction | 2020 |
| Sean the Butcher Limited | Wholesale & retail | 2023 |
| Seashell Properties Ltd | Real estate | 2022 |
| Seasonal Blooms Ltd | Wholesale & retail | 2024 |
| Secdata Ltd | Information & communication | 2006 |
| Secondary Steelwork Solutions Ltd | Manufacturing | 2013 |
| Secret Valley Escapes Ltd | Hospitality | 2016 |
| Secretarial Services Limited | Professional & scientific | 1980 |
| Secure Piling Solutions Limited | Construction | 2016 |
| SEE Hear Health Ltd | Wholesale & retail | 2024 |
| Seeitnowsports.Com Limited | Information & communication | 2009 |
| SEF VAT & Indirect Tax Consultants Ltd | Professional & scientific | 2014 |
| Senco Limited | Information & communication | 2010 |
| Senco Logistics Limited | Transport & logistics | 2005 |
| Senior Civils and Groundworks Ltd | Construction | 2018 |
| Senior Holdings Limited | Financial services | 2021 |
| Senrose Limited | Real estate | 2020 |
| Sentiant Limited | Construction | 2021 |
| Sentinel Waggon Works Limited | Other services | 2023 |
| Service Systems of Shepley Limited | Other services | 2003 |
| Sharc Retail (Holmfirth) Limited | Wholesale & retail | 2020 |
| Sharc Retail (Hubs) Limited | Wholesale & retail | 2023 |
| Sharp Civils Ltd | Information & communication | 2019 |
| Sharp Project Management Ltd | Construction | 2024 |
| Sharpe Hydraulic Services Ltd | Manufacturing | 2011 |
| Sharron Belcher Ltd | Other services | 2018 |
| Shaw 4 Electrical and Construction Ltd | Construction | 2021 |
| SHE Click Care Ltd | Information & communication | 2025 |
| Shenolikar Orthopaedic Services Limited | Health & social care | 2010 |
| Shin's Cleans Ltd | Administrative & support | 2025 |
| Shires Commercial Properties Ltd | Real estate | 2018 |
| Sigma Games Limited | Information & communication | 2012 |
| Simon Blyth Estate Agents (Barnsley) Limited | Real estate | 1999 |
| Simon James Castle Developments Ltd | Administrative & support | 2007 |
| Simply Customer Ltd | Administrative & support | 2013 |
| Simply IT (GB) Ltd | Information & communication | 2014 |
| Simply Smooth Health Ltd | Health & social care | 2014 |
| Simply the Beth Technical Services Ltd | Arts & recreation | 2023 |
| Simply Walls & Floors Ltd | Construction | 2022 |
| Simpson Asset Holdings Limited | Financial services | 2026 |
| Singing Hearts Collective CIC | Arts & recreation | 2025 |
| Singularity Logic Ltd | Extraterritorial | 2024 |
| Site Dog Limited | Arts & recreation | 2018 |
| Sithney Green Consulting Limited | Professional & scientific | 2022 |
| Sixers Cricket Coaching Ltd | Education | 2020 |
| SJC Commercial Ltd | Administrative & support | 2015 |
| SJT Electrical Contractors Yorkshire Limited | Construction | 2014 |
| SJW Enviro Consulting Ltd | Professional & scientific | 2016 |
| SK Pace Ltd | Education | 2025 |
| Sk(Northern) Consultancy Ltd | Other services | 2015 |
| Sketch Consulting Ltd | Professional & scientific | 2023 |
| Sketch Plate Ltd | Professional & scientific | 2021 |
| SKI Slopes International (UK) Limited | Manufacturing | 2014 |
| SKI Surface Manufacturing Limited | Manufacturing | 2014 |
| Skola Property Limited | Real estate | 2025 |
| Slaithwaite Commercial Properties Ltd | Real estate | 2022 |
| SLD Trading Ltd | Wholesale & retail | 2025 |
| Sleeplogik Limited | Other services | 2017 |
| Smart Operations Limited | Information & communication | 2026 |
| Smarter Solutions Limited | Wholesale & retail | 2001 |
| Smash Autos Limited | Wholesale & retail | 2025 |
| Smith Spa Ltd | Other services | 2023 |
| Smithson Business Advisory Limited | Professional & scientific | 2021 |
| SMP Haulage Ltd | Transport & logistics | 2026 |
| Smrlc Limited | Construction | 2023 |
| Snickers Original Limited | Extraterritorial | 2007 |
| Snickers Workwear Limited | Extraterritorial | 2011 |
| SO Dough Halifax Ltd | Hospitality | 2025 |
| SO Dough Pizzeria Ltd | Hospitality | 2023 |
| So-Ciety Holmfirth Ltd | Real estate | 2016 |
| Soak Events Limited | Other services | 2015 |
| Soap DE LA Cour Ltd | Manufacturing | 2022 |
| SOLUTIONS4 It(Hosting) Ltd | Information & communication | 2016 |
| SOLVE360 Ltd | Professional & scientific | 2018 |
| Solvit.Fm Ltd | Construction | 2019 |
| Somersby Properties Ltd | Real estate | 2022 |
| Sophalex Limited | Administrative & support | 2008 |
| Sophia's Meadow Limited | Construction | 2024 |
| Sorting Staff Ltd | Administrative & support | 2025 |
| South Leeds Investments Limited | Information & communication | 2022 |
| South Pennine Community Transport CIC | Transport & logistics | 2015 |
| Southfield Court Care Home Limited | Health & social care | 2023 |
| Sovereign Estate Shepley Limited | Real estate | 2025 |
| Sowler Systems Limited | Information & communication | 2016 |
| SP Designs (HD9) Limited | Professional & scientific | 2010 |
| SP Home Lettings Ltd | Real estate | 2025 |
| Spark Opportunity Ltd | Professional & scientific | 2023 |
| Sparkling Glass Limited | Administrative & support | 2002 |
| Sparkpoint Ltd | Information & communication | 2011 |
| Spartan Manufacturing Limited | Manufacturing | 2016 |
| Spartan REC2REC Limited | Administrative & support | 2025 |