| Rougestone Limited | Information & communication | 2011 |
| Route 28 Car Sales Limited | Wholesale & retail | 2018 |
| Route 28 Ltd | Manufacturing | 2011 |
| RS Commerce Ltd | Professional & scientific | 2015 |
| RSC Projects Ltd | Professional & scientific | 2018 |
| RTB Consultants Ltd | Professional & scientific | 1998 |
| Rush Properties Limited | Real estate | 2016 |
| Russian and Luxury Limited | Wholesale & retail | 2019 |
| RWB Solutions Ltd | Construction | 2020 |
| Ryan Lythe Auto Body Repairs Ltd | Wholesale & retail | 2016 |
| S N Fabrications Limited | Construction | 2007 |
| S W Surveyors Limited | Professional & scientific | 2014 |
| S&W (UK) Limited | Real estate | 2012 |
| S.B. & R. Realty Limited | Construction | 2009 |
| S.Briant Consulting Ltd | Professional & scientific | 2023 |
| Saanvi Store Ltd | Wholesale & retail | 2024 |
| Sabrina D Consulting Ltd | Administrative & support | 2024 |
| Saffronsupplies UK Limited | Wholesale & retail | 2024 |
| Saha Engineering Limited | Professional & scientific | 2011 |
| Salisbury Christian Care Homes (Inwood House) Limited | Health & social care | 2011 |
| Sally Hatcher Estates Limited | Real estate | 2012 |
| Salt Construction Kent Ltd | Construction | 2023 |
| Salt Training Limited | Education | 2023 |
| Saltwoods Healing & Massage Ltd | Other services | 2025 |
| Samesser Limited | Professional & scientific | 2010 |
| Sand Creative Ltd | Professional & scientific | 2013 |
| Sandco (South East) Limited | Education | 2021 |
| Sands Heating Services Ltd | Construction | 2019 |
| Sandwich Property Care Limited | Construction | 2017 |
| Sandwich Property Maintenance Limited | Construction | 2017 |
| Sanris Builders Ltd | Construction | 2012 |
| Sanris Developments Ltd | Construction | 2018 |
| Sanris Ltd | Financial services | 2018 |
| Saolis Consulting Limited | Information & communication | 2016 |
| Saolis Estates Ltd | Real estate | 2016 |
| Sarah Cuttle Photography Limited | Professional & scientific | 2010 |
| Sarah Farrant Consulting Limited | Financial services | 2015 |
| SAS Contracts Ltd | Construction | 2023 |
| Saxons Elite Cheer Ltd | Arts & recreation | 2026 |
| Sayer Associates Ltd | Professional & scientific | 2012 |
| SB Figures Ltd | Professional & scientific | 2003 |
| SB Stats Ltd | Information & communication | 2018 |
| SCA Talent Ltd | Administrative & support | 2024 |
| Scaffolding for Sale Ltd | Wholesale & retail | 2024 |
| Scarlee Ltd | Professional & scientific | 2024 |
| Scatter Press Limited | Administrative & support | 2022 |
| Scott Lawrence Estates Ltd | Real estate | 2024 |
| Screen Print Essentials Ltd | Wholesale & retail | 2011 |
| SD Home Projects Limited | Construction | 2025 |
| Seaside 3D Ltd | Manufacturing | 2018 |
| Seaside Life Properties Ltd | Real estate | 2017 |
| Security & Intelligence Solutions Ltd | Administrative & support | 2022 |
| Sedano Holdings Limited | Real estate | 2018 |
| Seedboys Ltd | Hospitality | 2022 |
| Seedpath AI Limited | Information & communication | 2025 |
| Select Latin America Limited | Administrative & support | 2002 |
| Selling Court Estates Limited | Real estate | 2008 |
| Semaphore Computing Ltd | Information & communication | 2009 |
| Senhen Ltd | Real estate | 2019 |
| Sequentis Partnership Ltd | Health & social care | 2018 |
| Seriously Bookkeeping Ltd | Professional & scientific | 2018 |
| Serra DOS Tucanos Birding Tours Limited | Administrative & support | 2015 |
| Seymour Rail Limited | Professional & scientific | 2016 |
| Shad Takeway Ltd | Hospitality | 2024 |
| Shaddick & Co. Limited | Extraterritorial | 2002 |
| Shaddick & Shaddick Limited | Construction | 2016 |
| Shaddick Commercial Ltd | Real estate | 2018 |
| Shaddick Properties Limited | Construction | 2020 |
| Shadeline Ltd | Wholesale & retail | 2023 |
| Shaneni Consultants Ltd | Administrative & support | 2014 |
| Shangress Limited | Professional & scientific | 2020 |
| Shard Partnership LLP | | 2021 |
| Shaw Business Protection Limited | Professional & scientific | 2007 |
| Shaws & Shaws Limited | Real estate | 2018 |
| SHE Business Travel Ltd | Administrative & support | 2025 |
| SHE Rose 165 Limited | Wholesale & retail | 2020 |
| Shedpegs Ltd | Construction | 2012 |
| Sheer Vinyl Attack Ltd | Wholesale & retail | 2023 |
| Shen Services Limited | Administrative & support | 2015 |
| Shilton Services Limited | Administrative & support | 2006 |
| Shipship Royale Ltd | Wholesale & retail | 2023 |
| Shire Conservation Ltd | Construction | 2022 |
| Shirley Appleby Ltd | Professional & scientific | 2003 |
| Showcase Investments Limited | Information & communication | 2025 |
| Shree Brow Bar Limited | Other services | 2020 |
| Shree Hari Letting Limited | Real estate | 2026 |
| Silk Salon Ltd | Other services | 2024 |
| Simply Homes 4 U Ltd | Other services | 2012 |
| Singapore Property Ltd | Real estate | 2026 |
| SIP Traders Kent Ltd | Hospitality | 2025 |
| Sirron Investment Ltd | Hospitality | 2017 |
| Sitetyre Limited | Wholesale & retail | 2016 |
| SIU Solutions Limited | Administrative & support | 2020 |
| SJD Consulting Limited | Professional & scientific | 2006 |
| SJR GAS Limited | Construction | 2021 |
| SKA Roofing Ltd | Construction | 2019 |
| Sketched Ltd | Professional & scientific | 2023 |
| Skinner Transport Ltd | Transport & logistics | 2024 |
| Skyframe Scaffolding Ltd | Construction | 2025 |
| Skyraisin Ltd | Financial services | 2025 |