| SUB1 (Birmingham 1) Limited | Information & communication | 2024 |
| SUB1 (Hoddesdon 1) Limited | Information & communication | 2024 |
| Sucruno Ltd | Extraterritorial | 2023 |
| Sudoplicity Limited | Information & communication | 2025 |
| SUE Coleman Associates Limited | Public administration | 2013 |
| SUE Lane Jewellery Limited | Manufacturing | 2021 |
| SUE Macartney-Snape Limited | Arts & recreation | 2004 |
| Suitsandsums Ltd | Professional & scientific | 2014 |
| Suli Barber Shop Ltd | Other services | 2024 |
| Sulii Barber Shop Ltd | Other services | 2025 |
| Sumacqua Ltd | Manufacturing | 2022 |
| Summit Inspections Ltd | Professional & scientific | 2024 |
| Summit Intelligence Ltd | Professional & scientific | 2025 |
| Sunderlands 1862 LLP | | 2008 |
| Sunderlands Limited | Professional & scientific | 2005 |
| Sunderlands Markets LLP | | 2023 |
| Sunrise Giants Limited | Extraterritorial | 2021 |
| SUNSET52 Ltd | Financial services | 2026 |
| Super Automotive Paintwork Limited | Wholesale & retail | 2002 |
| Super Polo Food Limited | Wholesale & retail | 2020 |
| Super Polo Plus Limited | Wholesale & retail | 2019 |
| Supersport International Limited | Professional & scientific | 2002 |
| Supersport Limited | Information & communication | 2006 |
| Supp Your Health Ltd | Health & social care | 2025 |
| Supply Solutions Ltd | Professional & scientific | 2013 |
| Support Air Limited | Professional & scientific | 2001 |
| Support Connect Ltd | Administrative & support | 2020 |
| Supreme Aviation Services Ltd | Administrative & support | 2026 |
| Supreme Protectionltd.Co.Uk Limited | Administrative & support | 2022 |
| Sure Fire Logs Ltd | Wholesale & retail | 2018 |
| Surefooted Media Ltd | Information & communication | 2020 |
| Surestate Limited | Information & communication | 2003 |
| Susanne L. COE Ltd. | Information & communication | 1998 |
| Sussex Medical and Dental Services Ltd | Health & social care | 2017 |
| Sutton Asbestos Surveys Limited | Professional & scientific | 2005 |
| Sutton House Global Ltd | Financial services | 2020 |
| Sutton House Ltd | Information & communication | 2005 |
| SW Maddy & SON Limited | Wholesale & retail | 2024 |
| SW12 Ltd | Real estate | 2001 |
| SW1A Limited | Real estate | 2001 |
| SW1B Limited | Real estate | 2013 |
| Swainshill Management Company Limited | Households | 2020 |
| Swan Court Ltd | Real estate | 2015 |
| Swanpine Limited | Hospitality | 2025 |
| Swansea Auto Engine Services Limited | Wholesale & retail | 1959 |
| Swayit Limited | Professional & scientific | 2019 |
| Sweet Surprise ES Ltd | Wholesale & retail | 2025 |
| Sweetman & Sons Limited | Real estate | 1953 |
| Sweetman Developments Ltd | Construction | 2009 |
| Swells Consulting Ltd | Professional & scientific | 2015 |
| Swift Motors (Hereford) Limited | Wholesale & retail | 2010 |
| Swift Services (Hereford) Limited | Construction | 2012 |
| Swift Stock Distribution Ltd | Wholesale & retail | 2025 |
| Swiftdocs AI Limited | Financial services | 2021 |
| Swiftory Ltd | Wholesale & retail | 2025 |
| Swisslogo AG Limited | Manufacturing | 2009 |
| Swordfish Advisory Ltd | Professional & scientific | 2025 |
| SWS Property Investments Limited | Real estate | 2011 |
| Swvs Ltd | Wholesale & retail | 2021 |
| Sybec Limited | Hospitality | 2018 |
| Sygnus Ltd | Construction | 2019 |
| Syla Studio Ltd | Professional & scientific | 2026 |
| Symbol of Success Racing Ltd | Professional & scientific | 2011 |
| Symonds & Co. (Hereford) Limited | Manufacturing | 1955 |
| Synchronome Clocks Ltd. | Manufacturing | 2013 |
| Synergy Chiropractic Limited | Health & social care | 2021 |
| Synergy International Ltd | Administrative & support | 2023 |
| Syntra Systems Limited | Manufacturing | 2025 |
| Syops Limited | Administrative & support | 2022 |
| Szewc Bros Limited | Construction | 2017 |
| T & M Properties (Hereford) Ltd | Real estate | 2020 |
| T & T Fitness Ltd | Arts & recreation | 2021 |
| T & T Plant Hire Limited | Construction | 2018 |
| T & T Vaping Services Ltd | Wholesale & retail | 2017 |
| T B W Services Ltd | Manufacturing | 2022 |
| T Dines Electrical Limited | Construction | 2022 |
| T G Marketing Group Ltd | Professional & scientific | 2020 |
| T J Groundworks Ltd | Construction | 2005 |
| T Mian Medical Services Limited | Health & social care | 2013 |
| T W Business Solutions LLP | | 2007 |
| T W Jones & Sons (HFD) Limited | Water & waste | 2021 |
| T&H Consultants Limited | Administrative & support | 2023 |
| T&L Investments Ltd | Real estate | 2014 |
| T-Continuum Limited | Health & social care | 2020 |
| T. & G. Davies (Mumbles) Limited | Manufacturing | 1960 |
| T.A.Matthews Solicitors Ltd | Professional & scientific | 2013 |
| T.H.W Enterprises Ltd | Households | 2018 |
| T.J. Crump Oakwrights Limited | Construction | 1999 |
| T.L.Walden Limited | Construction | 2021 |
| T.S.Henderson & Co.Limited | Manufacturing | 1934 |
| T2 Fabrication Limited | Construction | 2017 |
| T4G Limited | Administrative & support | 2006 |
| Tackeroo Limited | Real estate | 2015 |
| Tactical Advance Production Services Limited | Information & communication | 2014 |
| Tactical Insight Group Ltd | Administrative & support | 2024 |
| Tacura Limited | Wholesale & retail | 2020 |
| Tagmata Limited | Administrative & support | 2023 |
| Tailor-Made Designs Holdings Limited | Financial services | 2022 |
| Tailor-Made Designs Ltd | Manufacturing | 2006 |
| TAK Therapies Ltd | Health & social care | 2021 |