| UK QMS Services Ltd | Information & communication | 2018 |
| UK Ryder Ltd | Wholesale & retail | 2018 |
| Ultima Composites Ltd | Manufacturing | 2024 |
| Ultima Enterprises Ltd | Manufacturing | 2020 |
| Ultima Golf Derby Ltd | Arts & recreation | 2026 |
| Ultima Golf Nottingham Ltd | Arts & recreation | 2026 |
| Umeco Limited | Professional & scientific | 1917 |
| Unity Gym Heanor Ltd | Arts & recreation | 2026 |
| Up-Town Tanning Ltd | Other services | 2019 |
| Uptown Beauty Limited | Other services | 2024 |
| Urban Craft Builders Ltd | Real estate | 2024 |
| Urban Developments (Derby) Ltd | Real estate | 2025 |
| VAM Ltd | Health & social care | 2016 |
| Vantage Aluminium Limited | Manufacturing | 2023 |
| Vero Homes Ltd | Construction | 2022 |
| Vero Motors Ltd | Wholesale & retail | 2022 |
| Verveline Limited | Wholesale & retail | 2023 |
| Vispera Limited | Information & communication | 1997 |
| Vitanova Care Ltd | Health & social care | 2025 |
| Vivelo Ltd | Hospitality | 2021 |
| W B Power Services Limited | Manufacturing | 1987 |
| W.N.S Electrical Services Ltd | Construction | 2020 |
| Waterside Park (Ashbourne) Management Company Limited | Real estate | 2008 |
| Watsons Accountancy Limited | Professional & scientific | 2020 |
| Wellglade Holdings Limited | Professional & scientific | 2010 |
| Wells Built Limited | Construction | 2025 |
| Wheatley Cleaning Solutions Ltd | Administrative & support | 2025 |
| Whymaker Limited | Hospitality | 2025 |
| Wild Outlaw Clothing Co Ltd | Wholesale & retail | 2024 |
| William Clarence Properties Limited | Real estate | 2013 |
| William Frost (Heanor) Limited | Real estate | 1946 |
| Willow Cleaning Services Ltd | Administrative & support | 2020 |
| Willow Furnishing Limited | Other services | 2013 |
| Willow Wood Ltd | Hospitality | 2022 |
| Wiltech Acoustics Limited | Manufacturing | 2023 |
| Wood Bros Heanor Limited | Wholesale & retail | 2015 |
| Worcester Garden Limited | Health & social care | 2002 |
| Wrightstart Ltd | Education | 2014 |
| Wulf Investments Limited | Construction | 2001 |
| Www.Castfireplaces.Co.Uk Limited | Wholesale & retail | 2008 |
| X-Cel Construct Limited | Construction | 2002 |
| Xcite Audio Services Ltd | Arts & recreation | 2005 |
| XL Construction MG Limited | Construction | 2008 |
| XL Lofts Ltd. | Construction | 2017 |
| Xolas Ltd | Hospitality | 2020 |
| Your Feet First Limited | Health & social care | 2021 |
| Zentatrade Hub Ltd | Wholesale & retail | 2025 |