| Serene Lives CIC | Health & social care | 2022 |
| Service Hub Solutions Ltd | Transport & logistics | 2024 |
| Sharpe & Sons Property Limited | Real estate | 2016 |
| Sharps Home Improvements Ltd | Construction | 2019 |
| Sheruba Ltd | Professional & scientific | 2018 |
| Shipley Developments Ltd | Construction | 2020 |
| Shipley Renovations Ltd | Construction | 2025 |
| Shirleen Ltd | Construction | 2019 |
| Shyan Limited | Real estate | 2023 |
| Silly Sentiments Limited | Manufacturing | 2016 |
| Simply Capsules Ltd | Wholesale & retail | 2018 |
| Simply Scents Ltd | Wholesale & retail | 2011 |
| Sjjl Ltd | Construction | 2022 |
| Skylight Property Group Limited | Real estate | 2022 |
| Skylight Property SA Limited | Construction | 2023 |
| Sleep in Motion Limited | Arts & recreation | 2023 |
| SLS Compliance Ltd | Professional & scientific | 2024 |
| SLS Distribution Limited | Wholesale & retail | 2012 |
| Smalley View Farm Limited | Agriculture & fishing | 2018 |
| Smart Education Systems Ltd | Education | 2026 |
| Smartgov Ltd | Information & communication | 2017 |
| SND Management Ltd | Hospitality | 2025 |
| SNOWDROPS29 Ltd | Other services | 2021 |
| Socialmyna Ltd | Professional & scientific | 2013 |
| Solace Care Solutions Limited | Education | 2017 |
| Solar Footprint Ltd | Construction | 2022 |
| Space Captures Ltd | Professional & scientific | 2020 |
| Spectrum Housing CIC | Real estate | 2020 |
| Spray Revive Ltd | Construction | 2021 |
| Springfield Horses Limited | Administrative & support | 2019 |
| Sssa Properties Limited | Real estate | 2025 |
| ST Architecture and Design Limited | Professional & scientific | 2018 |
| ST Michael's Property Investments Ltd | Real estate | 2017 |
| ST Peters Court (Riddings) Limited | Households | 2007 |
| Stage Presence Touring Ltd | Transport & logistics | 2025 |
| Stanicrete Ltd | Construction | 2023 |
| Star Fleet Services Ltd | Wholesale & retail | 2025 |
| Starsleeper Bussing Ltd | Transport & logistics | 2025 |
| Stash Ilkeston Ltd | Wholesale & retail | 2017 |
| Station 27 Limited | Wholesale & retail | 2007 |
| Stay Well Health Limited | Health & social care | 2017 |
| Stay Well Health Yoga Limited | Arts & recreation | 2021 |
| Stedmark Limited | Manufacturing | 2004 |
| Steel-Tech Fabrication & Installation Ltd | Construction | 2022 |
| Stepping Stones (Amber Valley) | Health & social care | 2000 |
| Storeship Ltd | Wholesale & retail | 2009 |
| Stratford Innovations Limited | Wholesale & retail | 2014 |
| Stuart Anthony Limited | Construction | 2011 |
| Supreme Retail Solutions Ltd | Wholesale & retail | 2025 |
| Swear Blind Ltd | Information & communication | 2022 |
| Swimright Consultancy Limited | Professional & scientific | 2023 |
| T M Travel Limited | Transport & logistics | 2004 |
| T Piggott Home Improvement & Joinery Ltd | Construction | 2022 |
| T.D. Interiors Kitchens, Bedrooms & Bathrooms Ltd | Manufacturing | 2017 |
| T2 Systems Ltd | Information & communication | 2025 |
| Tailor My Style Limited | Wholesale & retail | 2025 |
| Talisker Consultancy Ltd | Professional & scientific | 2025 |
| Tank Investments Limited | Real estate | 2025 |
| Tansley Sealant Solutions Ltd | Construction | 2022 |
| TARGET4TODAY Limited | Administrative & support | 2007 |
| Tarnex Group Ltd | Administrative & support | 2024 |
| Taskforgeuk Ltd | Wholesale & retail | 2025 |
| Tasty Catering Ltd | Hospitality | 2019 |
| Tasty Taterz Limited | Hospitality | 2025 |
| Taveta Enterprises Limited | Real estate | 2018 |
| Tech Hire Services Ltd | Information & communication | 2023 |
| THE Bay Leaf One Ltd | Hospitality | 2025 |
| THE Coach at Horsley Limited | Real estate | 2018 |
| THE Intelligent Home Store Limited | Administrative & support | 2025 |
| THE Lions DEN Boxing Club CIC | Arts & recreation | 2021 |
| THE Marlpool ALE House Limited | Hospitality | 2012 |
| THE Marlpool Brewing Company Limited | Manufacturing | 2010 |
| THE R500 Property Company Limited | Real estate | 2000 |
| THE Salvogroup Ltd | Wholesale & retail | 2002 |
| THE Stag Barbershop Heanor Limited | Other services | 2017 |
| THE Teeny Corporation Ltd | Hospitality | 2018 |
| THE Temple Brothers Ltd | Arts & recreation | 2021 |
| THE Twisted Tavern Ltd | Manufacturing | 2021 |
| THE Urban Furniture Emporium Ltd | Other services | 2022 |
| THE Wilmott Group Limited | Financial services | 2023 |
| THE Wire Brigade Ltd | Manufacturing | 2016 |
| Thought Process Consulting Ltd | Information & communication | 2016 |
| TIM Properties Limited | Real estate | 2018 |
| Todays Developments Ltd | Construction | 2006 |
| TOM Singleton Productions Ltd | Administrative & support | 2020 |
| Toni Enterprises Ltd | Other services | 2025 |
| Topline Commercials Ltd | Wholesale & retail | 2020 |
| Total Shine Ltd | Administrative & support | 2021 |
| Tourx Ltd | Transport & logistics | 2026 |
| Trans-Rak International Limited | Manufacturing | 2017 |
| Trans-Rak Trading Limited | Manufacturing | 2002 |
| Transport Law UK Ltd | Professional & scientific | 2026 |
| Travel Searcher Ltd | Administrative & support | 2017 |
| Treatlab Ltd | Wholesale & retail | 2025 |
| Tricron Limited | Information & communication | 2014 |
| Trident Electrical & Testing Limited | Construction | 2026 |
| Trident Integrated Services Ltd | Construction | 2024 |
| True Performance Golf Ltd | Wholesale & retail | 2025 |
| UK Car Buyer (Derby) Limited | Wholesale & retail | 2020 |
| UK Foot Pool Ltd | Administrative & support | 2015 |