| Robinsons of Wingate Ltd | Hospitality | 2015 |
| Robotic Crawler Systems Limited | Professional & scientific | 2022 |
| Robson & Williamson Ltd | Construction | 2018 |
| Rocha Rope Access Ltd | Professional & scientific | 2020 |
| Rocks Training Ltd | Education | 2023 |
| Rodolfo Limited | Real estate | 1991 |
| Roger Heywood (Tax & Accountancy) Limited | Professional & scientific | 1988 |
| Romeo Pizzeria (Hartlepool) Limited | Hospitality | 2023 |
| RON Perry & SON Limited | Wholesale & retail | 1978 |
| RON Perry Holdings Limited | Financial services | 2013 |
| Ronlyn Limited | Construction | 2013 |
| Roofers in Teesside Ltd | Construction | 2022 |
| Room With a View Limited | Real estate | 2020 |
| Roro Group Holdings Limited | Financial services | 2026 |
| Rose and Grace Holdings Limited | Financial services | 2025 |
| Rosewood Properties Investments LLP | | 2008 |
| Rosory Safety Services Limited | Other services | 2023 |
| Rosso Refined Ltd | Wholesale & retail | 2025 |
| Rowman Construction Limited | Construction | 2026 |
| Roxys-Rainbow Pet Cremation Ltd | Other services | 2020 |
| Royle Rigging Limited | Construction | 2014 |
| Rozvi Ltd | Health & social care | 2015 |
| RPN Designs Ltd | Professional & scientific | 2014 |
| Rpne Ltd | Manufacturing | 2025 |
| RRD Direct Ltd | Construction | 2019 |
| Rrshp Ltd | Wholesale & retail | 2026 |
| RS Alloy Refurb Ltd | Wholesale & retail | 2017 |
| RSL Cars Ltd | Wholesale & retail | 2011 |
| Rtkw Ltd | Professional & scientific | 2026 |
| Ruby Moonbeam Merrick Ltd | Extraterritorial | 2024 |
| Rudby (Properties) Limited | Construction | 1996 |
| Ruff Retreat Ltd | Wholesale & retail | 2025 |
| RV Bespoke Ltd | Manufacturing | 2025 |
| Ryan Property Management (NE) Limited | Real estate | 2025 |
| Ryder Inspection Services Limited | Professional & scientific | 2022 |
| Ryder Safety Services Limited | Professional & scientific | 2020 |
| S & B Groundwork Services Ltd | Construction | 2025 |
| S & K Properties Northeast Limited | Real estate | 2025 |
| S & Z Trading Limited | Transport & logistics | 2017 |
| S C + J Trading Company Limited | Administrative & support | 2002 |
| S C Inspection Ltd | Professional & scientific | 2018 |
| S G S Safety Services Limited | Other services | 2013 |
| S I'A Electrotech Ltd | Construction | 2010 |
| S J Ryle Properties Limited | Real estate | 2025 |
| S Lithgo Roofing Contractors Ltd | Construction | 2021 |
| S Mackney Ltd | Other services | 2017 |
| S Purvis Limited | Hospitality | 2024 |
| S Smith Civil Engineering Limited | Construction | 2023 |
| S&B Property NE Ltd | Real estate | 2026 |
| S.A.B. Supply Limited | Administrative & support | 2011 |
| S.E.C Southern Ltd | Professional & scientific | 2019 |
| S.E.D. Management Ltd | Construction | 2020 |
| S.M. Tech Services Ltd | Professional & scientific | 2021 |
| S.Mcleod Limited | Construction | 2013 |
| S.W Welding Services Ltd | Construction | 2019 |
| S0 Planning Engineering Limited | Administrative & support | 2014 |
| S1000 Ltd | Energy | 2013 |
| Sabha Property Developments Limited | Construction | 2018 |
| Sachets and More Limited | Wholesale & retail | 2017 |
| Sadiq Properties Limited | Real estate | 2017 |
| Sadorect Systems Ltd | Information & communication | 2025 |
| Safeguarding Practitioners Limited | Professional & scientific | 2014 |
| Safety in Process Limited | Information & communication | 2024 |
| Safu 55 Ltd | Hospitality | 2026 |
| Sahota & Randhawa's Ltd | Hospitality | 2024 |
| Saif Pizzeria Ltd | Hospitality | 2019 |
| Sainty Services Ltd | Construction | 2020 |
| Saltburn Memorials Limited | Other services | 2018 |
| Salvins Welding Services Ltd | Construction | 2024 |
| SAM Dunn Ltd | Arts & recreation | 2013 |
| Sambuca Hartlepool Ltd | Hospitality | 2023 |
| Sambuca Windmill Ltd | Hospitality | 2024 |
| Sammy Bianco Limited | Hospitality | 2009 |
| Samstalltd Ltd | Manufacturing | 2025 |
| Samuel Uber Driver Ltd | Transport & logistics | 2025 |
| Sanco Food and Drink Ltd | Wholesale & retail | 2024 |
| Sandersons Associates Property Rentals Limited | Real estate | 2011 |
| Sandgate Plant Hire Limited | Extraterritorial | 2009 |
| Sandgate Recycling Limited | Extraterritorial | 2009 |
| Sandycove Capital Limited | Professional & scientific | 2021 |
| Sanvia Housing (Middlesbrough) Ltd | Construction | 2025 |
| SAR Safety Limited | Professional & scientific | 2016 |
| Sarah Railton Medical Limited | Health & social care | 2023 |
| Sarwar GP Locums Ltd | Health & social care | 2010 |
| SAS Builder Ltd | Construction | 2025 |
| Sats Mastery Ltd | Information & communication | 2024 |
| Saunders Hill Brighton Limited | Real estate | 2023 |
| Savvy BRO Limited | Hospitality | 2017 |
| Sbbl Limited | Professional & scientific | 2018 |
| SBR NP 25 Ltd | Hospitality | 2025 |
| Scalenta Capital Ltd | Financial services | 2025 |
| Scallle.Com Ltd | Professional & scientific | 2024 |
| Scarborough Street Social Ltd | Hospitality | 2024 |
| Scatter Management Limited | Real estate | 2025 |
| Schofield Logistics Ltd | Transport & logistics | 2026 |
| Science Studio Limited | Wholesale & retail | 2005 |
| Scope NDT Solutions UK Limited | Professional & scientific | 2023 |
| Scope Project Delivery Ltd | Construction | 2026 |
| Scott Newbegin Limited | Administrative & support | 2012 |
| Scott Plant Hire & Groundwork Limited | Construction | 2003 |