| Spill Land Farm Country Park Limited | Real estate | 2018 |
| Spiller Media Limited | Information & communication | 2024 |
| Spinach Coaching Limited | Professional & scientific | 2022 |
| Spinboxx Ltd | Arts & recreation | 2018 |
| Spinitin Ltd | Information & communication | 2021 |
| Spinvalley.Com Limited | Information & communication | 2001 |
| Spira Property Group Limited | Real estate | 2026 |
| Spiral International Ltd | Wholesale & retail | 2016 |
| Spireprop Ltd | Real estate | 2022 |
| Spirit of Balance Limited | Professional & scientific | 2018 |
| Spirited Designs Limited | Arts & recreation | 2022 |
| Spiritmaster Limited | Information & communication | 2018 |
| Spiro Therapy Limited | Health & social care | 2023 |
| Spitalfields Office Ltd | Real estate | 2019 |
| SPJ Estates Ltd | Real estate | 2019 |
| Spjp Investments Ltd | Administrative & support | 2025 |
| SPK Bushey Ltd | Construction | 2019 |
| SPK Development Ltd | Construction | 2024 |
| SPK Group Ltd | Hospitality | 2012 |
| SPK Orchard Park Limited | Financial services | 2017 |
| SPK Residential Cambridge Ltd | Construction | 2015 |
| SPL Group Holding Limited | Financial services | 2020 |
| SPL Homes Ltd | Arts & recreation | 2019 |
| Splash Contractor Limited | Construction | 2025 |
| Splendid E&S Deco Ltd | Construction | 2022 |
| Splitspace Ltd | Real estate | 2024 |
| SPM International Ltd | Wholesale & retail | 2023 |
| Spokly Ltd | Other services | 2026 |
| Sportrex Ltd | Wholesale & retail | 2018 |
| Sports Coordinating Committee of Tamils | Arts & recreation | 2024 |
| Sports Medicine Limited | Health & social care | 2005 |
| Sports Merchants Ltd | Information & communication | 2021 |
| Sports Outcome Probabilities Limited | Arts & recreation | 1998 |
| Sports Tours Andalusia Ltd | Administrative & support | 2022 |
| Sportsnuts Limited | Wholesale & retail | 2007 |
| Sportz Solutions UK Limited | Information & communication | 2025 |
| Spot on Digital Consulting Limited | Professional & scientific | 2020 |
| Spot on Planning and Management Limited | Professional & scientific | 2021 |
| Spotless Films Ltd | Information & communication | 2026 |
| Spotlight Talent Ltd | Arts & recreation | 2021 |
| SPP Building Services Limited | Construction | 2014 |
| SPP Properties (UK) Limited | Real estate | 2016 |
| SPR Mepani Ltd | Real estate | 2026 |
| Sprayceuticals Ltd | Wholesale & retail | 2026 |
| Spraykings Ltd | Administrative & support | 2026 |
| Spri Investments Ltd | Real estate | 2024 |
| Springchurch Limited | Real estate | 2018 |
| Springfield Cottages (UK) Limited | Health & social care | 2024 |
| Springfield Facilities Limited | Financial services | 2003 |
| Springfield Finance Ltd | Administrative & support | 2010 |
| Springfield Securities Limited | Financial services | 2017 |
| Springs Living UK Ltd | Real estate | 2022 |
| Springtime Care Limited | Health & social care | 2023 |
| Springwell Avenue RTM Company Limited | Households | 2021 |
| Springwell Consulting Limited | Information & communication | 2020 |
| Springy Limited | Information & communication | 2021 |
| Sprinkles Street Ltd | Wholesale & retail | 2025 |
| Spritely Services Ltd | Professional & scientific | 2021 |
| Sprout Chicks UK (PVT) Ltd | Wholesale & retail | 2024 |
| Sprout Productions Limited | Information & communication | 2021 |
| Sproutstride Ltd | Information & communication | 2019 |
| Sprukfield (UK) Limited | Professional & scientific | 2005 |
| Spsmn Ltd | Real estate | 2021 |
| Spsp Properties Ltd | Real estate | 2016 |
| SPT Accountants & Co Limited | Professional & scientific | 2017 |
| SPT Holding Management Ltd | Real estate | 2023 |
| SPT Homes Limited | Real estate | 2021 |
| Sptn Consulting Ltd | Real estate | 2026 |
| Sptp Properties Ltd | Real estate | 2023 |
| Spudalicious Limited | Hospitality | 2024 |
| SPV Kara Investments Ltd | Real estate | 2025 |
| SPV Pinner Limited | Real estate | 2025 |
| SPV Trafford Fireplaces Limited | Wholesale & retail | 2021 |
| SQS Group (UK) Limited | Professional & scientific | 2012 |
| SQS Services Limited | Extraterritorial | 2022 |
| Squad Estates Ltd | Real estate | 2025 |
| Squad in Touch Ltd | Information & communication | 2015 |
| Square Guys H Ltd | Hospitality | 2022 |
| Square Guys Holdings Ltd | Professional & scientific | 2021 |
| Square Guys Ltd | Hospitality | 2019 |
| Square Guys SHB Limited | Hospitality | 2022 |
| Square Guys W Ltd | Hospitality | 2021 |
| Square MAN Lighting Services Limited | Construction | 2014 |
| Square Mile Insurance Services Limited | Financial services | 1998 |
| Squareart Ltd | Arts & recreation | 2016 |
| Squire Estates Limited | Construction | 2011 |
| Squires Estate Agents Limited | Administrative & support | 2007 |
| Squirrel Realty 4 Limited | Real estate | 2025 |
| Squirrel Realty 5 Limited | Real estate | 2025 |
| Squirrels Close Flats Management Limited | Households | 2004 |
| Squish Media Limited | Information & communication | 2013 |
| Squonk Limited | Information & communication | 2017 |
| SR Alcohols & Wines Ltd | Wholesale & retail | 2025 |
| SR Banani Limited | Manufacturing | 2016 |
| SR Bespoke-Joinery Limited | Manufacturing | 2021 |
| SR Car Sper Ltd | Wholesale & retail | 2026 |
| SR Construction Services Ltd | Construction | 2017 |
| SR Food Ventures Ltd | Wholesale & retail | 2025 |
| SR Global Payments Limited | Other services | 2025 |
| SR Independent Medical Practitioner (Consultant Psychiatrist) Limited | Health & social care | 2018 |