| Span Limited | Professional & scientific | 2025 |
| Spar (UK) Limited | Wholesale & retail | 1959 |
| Spar Food Distributors Limited | Wholesale & retail | 1975 |
| Sparch Property Management Limited | Real estate | 2015 |
| Spark Chase Ltd | Wholesale & retail | 2021 |
| Spark Consultancy PVT Limited | Wholesale & retail | 2025 |
| Spark Digital UK Ltd | Professional & scientific | 2026 |
| Spark Group Properties Ltd | Real estate | 2024 |
| Spark Nexus Ltd | Wholesale & retail | 2025 |
| Spark NRG Ltd | Real estate | 2019 |
| Sparkle and Go Ltd | Administrative & support | 2021 |
| Sparkle and Reign Limited | Manufacturing | 2018 |
| Sparkle CS EBT Ltd | Financial services | 2025 |
| Sparkle CS Ltd | Information & communication | 2010 |
| Sparkle House Ltd | Administrative & support | 2022 |
| Sparkline Jewles Limited | Manufacturing | 2025 |
| Sparkling Window Cleaners Ltd | Administrative & support | 2025 |
| Sparks DRG Limited | Construction | 2026 |
| Sparkshire Development Limited | Construction | 2020 |
| Sparkshire Investments Limited | Construction | 2021 |
| Sparrow Aviation Services Limited | Transport & logistics | 2003 |
| Sparrow Estates Limited | Construction | 1993 |
| Sparrow Path Ltd | Information & communication | 2026 |
| Sparsh Investment Ltd | Real estate | 2022 |
| Sparshdigital Limited | Manufacturing | 2024 |
| Spartan International Executive Search Limited | Administrative & support | 2011 |
| Spartan Security Solutions Ltd | Administrative & support | 2019 |
| Speak 2 a Geek Limited | Information & communication | 2005 |
| Speak Digital Limited | Information & communication | 2010 |
| Speak Smart Ltd | Education | 2024 |
| Special Letting Ltd | Real estate | 2020 |
| Special Needs Community C.I.C. | Administrative & support | 2017 |
| Special Tokens Ltd | Wholesale & retail | 2020 |
| Specialty MGA Africa and Middle East Limited | Professional & scientific | 2023 |
| Specialty MGA Holdings Limited | Financial services | 2026 |
| Specialty MGA Retakaful Limited | Financial services | 2023 |
| Specialty MGA UK Limited | Financial services | 2021 |
| Specialty Scanners Limited | Manufacturing | 2000 |
| Specs-Exchange UK Limited | Financial services | 2020 |
| SPECS2GO Ltd | Wholesale & retail | 2025 |
| Specsmania Limited | Wholesale & retail | 2006 |
| Spectre Property Group Ltd | Real estate | 2024 |
| Spectroom Property Maintenance Limited | Construction | 2005 |
| Spectrum Arkitecture Ltd | Professional & scientific | 2024 |
| Spectrum IV Limited | Real estate | 2020 |
| Spectrum Medic Plus Limited | Health & social care | 2010 |
| Spectrum Search (2022) Limited | Professional & scientific | 2022 |
| Spectrum Search Limited | Administrative & support | 2018 |
| Spectrum Wealth Planning LLP | | 2026 |
| Spectrum Wills & Estate Planning Ltd | Other services | 2026 |
| Spectrumpulse Ltd | Wholesale & retail | 2024 |
| Speech and Language Therapy London Ltd | Health & social care | 2023 |
| SPEED8 Ltd | Wholesale & retail | 2025 |
| Speedbird Air Limited | Transport & logistics | 2003 |
| Speedia Ltd | Professional & scientific | 2025 |
| Speedline Express Ltd | Transport & logistics | 2025 |
| Speednine Limited | Wholesale & retail | 2016 |
| Speedset Retail Ltd | Other services | 2018 |
| Speeduplogistic Ltd | Transport & logistics | 2019 |
| Speedway Relocation (UK) Limited | Transport & logistics | 2022 |
| Speedy 4 Care Ltd | Health & social care | 2024 |
| Speedy Flooring Limited | Transport & logistics | 2004 |
| Speedy Go Logistics Ltd | Administrative & support | 2018 |
| Speedy Skips Ltd | Water & waste | 2012 |
| Speedy Turtle Ltd | Wholesale & retail | 2017 |
| Speedygrace Exceptionalism Limited | Transport & logistics | 2024 |
| Speedyhelper Ltd | Administrative & support | 2023 |
| Spellbound Media Ltd | Arts & recreation | 2024 |
| Spellbound Properties Limited | Real estate | 2018 |
| Spencer Property Management Services Ltd | Real estate | 2024 |
| Spencerroadharrow Ltd | Real estate | 2024 |
| Spendwise Accountancy Ltd | Professional & scientific | 2022 |
| Spendwise Assets Ltd | Real estate | 2023 |
| Spendwise Company Formation Ltd | Professional & scientific | 2022 |
| Spendwise Financials Ltd | Households | 2020 |
| Spendwise Investments Ltd | Real estate | 2022 |
| Spendwise Projects Ltd | Real estate | 2023 |
| Spendwise Projects Services Ltd | Professional & scientific | 2019 |
| Spendwise Technologies Ltd | Information & communication | 2022 |
| Spenrig Services Limited | Construction | 2024 |
| Speros Consulting Limited | Education | 2020 |
| Spetto Limited | Extraterritorial | 2017 |
| SPG Housing Solutions Limited | Real estate | 2019 |
| Sphere PCN Ltd | Health & social care | 2022 |
| Sphere Property Links Ltd | Real estate | 2017 |
| Spheroid (UK) Limited | Wholesale & retail | 1992 |
| Sphynx Property Limited | Real estate | 2019 |
| SPI Services Limited | Construction | 2018 |
| Spice Productions Limited | Information & communication | 2022 |
| Spice Shack London Ltd | Hospitality | 2015 |
| Spicenest Ventures Ltd | Hospitality | 2026 |
| Spicy Dine Ltd | Hospitality | 2025 |
| Spicy Hot Rooster Ltd | Hospitality | 2025 |
| Spicy Moon Limited | Other services | 2025 |
| Spicy Touch (UK ) Limited | Hospitality | 2017 |
| Spider Interiors Ltd | Wholesale & retail | 2017 |
| Spiderone Football Development Ltd | Education | 2020 |
| Spiffy Designs Ltd | Professional & scientific | 2013 |
| Spifix Limited | Information & communication | 2017 |
| Spiker Services Ltd | Information & communication | 2025 |