| SG Carpentry Ltd | Manufacturing | 2024 |
| SG Spasov Ltd | Construction | 2010 |
| SGC Construct Ltd | Construction | 2019 |
| Sgcfm Ltd | Professional & scientific | 2005 |
| SGR Construction Ltd | Construction | 2017 |
| Sgvbuilders Ltd | Construction | 2021 |
| SH Ambassador's Ltd | Other services | 2025 |
| SH Mortgages Ltd | Financial services | 2024 |
| Shadelz Ltd | Health & social care | 2020 |
| Shaenkdreams Ltd | Health & social care | 2022 |
| Shaf Enterprises Limited | Transport & logistics | 2022 |
| Shafiqoph Ltd | Health & social care | 2023 |
| Shah Legacy Holdings Ltd | Financial services | 2025 |
| Shah Motorsports Ltd | Wholesale & retail | 2016 |
| Shaheen Zahoor Co Ltd | Health & social care | 2026 |
| Shaheena Ltd | Wholesale & retail | 2025 |
| Shai London Limited | Other services | 2026 |
| Shais Stories Ltd | Wholesale & retail | 2024 |
| Shalombiz Global Resources Limited | Wholesale & retail | 2013 |
| Sham Enterprise Limited | Hospitality | 2019 |
| Shamrock Care Ltd | Health & social care | 2023 |
| Shanaz ALI Limited | Health & social care | 2019 |
| Sharine Limited | Health & social care | 2021 |
| Sharks Cricket Academy CIC | Education | 2024 |
| Sharpe Garbage Removal Ltd | Water & waste | 2021 |
| Sharper Styles Barbers Limited | Other services | 2023 |
| Sharrow D.C. Ltd | Health & social care | 2024 |
| Shas H Food Ltd | Hospitality | 2025 |
| Shaun Burnett Limited | Administrative & support | 2013 |
| Shavelli Construction Ltd | Construction | 2017 |
| Shawbridge Accounting Limited | Professional & scientific | 2026 |
| Shawbridge Holdings Limited | Financial services | 2026 |
| Sheaworks Ltd | Construction | 2014 |
| Shebaby Global Productions Ltd | Information & communication | 2023 |
| Shefford (BH) Management Limited | Households | 2013 |
| Shefford Leys Management Company Limited | Households | 2013 |
| Shehi Groundwork Services Ltd | Construction | 2023 |
| Shekinah Roots Ltd | Professional & scientific | 2017 |
| Shelley Court Residents Limited | Households | 2006 |
| Shelly Court Management Company Limited | Real estate | 1989 |
| Shepherds Mews Management Limited | Households | 2019 |
| Shepley Mews Management Company Limited | Households | 1984 |
| Sheriff Group Ltd | Construction | 2021 |
| Sherin Limited | Real estate | 2019 |
| Sherrys Food Limited | Manufacturing | 2016 |
| Shezdt Limited | Health & social care | 2020 |
| Shield Energy Assessment Ltd | Households | 2024 |
| Shieldwise Healthcare Ltd | Health & social care | 2025 |
| Shieldwise Services Limited | Administrative & support | 2016 |
| Shimgrange Limited | Households | 1980 |
| Shine With Glam Limited | Other services | 2026 |
| Shingler Logistics Limited | Transport & logistics | 2025 |
| Ship Shape Stove Services Limited | Manufacturing | 2021 |
| Shippcycles Ltd | Manufacturing | 2011 |
| Shire Village Inns Limited | Hospitality | 2001 |
| Shivaay Properties Limited | Real estate | 2017 |
| Shogaz Limited | Health & social care | 2021 |
| Shooting Star Enterprises Limited | Hospitality | 2016 |
| Shopitright Ltd | Wholesale & retail | 2020 |
| Shorts Close Management Limited | Households | 2022 |
| Shot by JAY Ltd | Professional & scientific | 2023 |
| Shotunde Consulting Company Ltd | Health & social care | 2021 |
| Shotwave Ltd | Hospitality | 2023 |
| Show & Events Group Limited | Extraterritorial | 2011 |
| Show & Events Security Limited | Other services | 2018 |
| Show & Events Training Limited | Extraterritorial | 2011 |
| Showcase Collectibles Ltd | Administrative & support | 2026 |
| Shower Image Ltd | Wholesale & retail | 2011 |
| Shpetim Bebja Ltd | Wholesale & retail | 2023 |
| Shudbettycleanandclear Ltd | Administrative & support | 2025 |
| Shunara's Kitchen Ltd | Hospitality | 2024 |
| Shupadex Healthcare Ltd | Administrative & support | 2024 |
| Shushanworld Travels International Limited | Administrative & support | 2023 |
| Shuttle Ltd | Other services | 2014 |
| SHV Group Ltd | Construction | 2020 |
| Shwe TAN Limited | Other services | 2010 |
| SI Community Assets CIC | Arts & recreation | 2022 |
| SI Racha Thai Massage & Therapy Ltd | Other services | 2022 |
| SI XL Limited | Health & social care | 2023 |
| SIA Sale Services Ltd | Extraterritorial | 2022 |
| SIB Property Services Ltd | Construction | 2024 |
| Sibtas Ltd | Real estate | 2022 |
| SIC Transport Ltd | Transport & logistics | 2017 |
| Sicilia Doro Ltd | Hospitality | 2023 |
| Sickamps Ltd | Other services | 2017 |
| Sidamot Limited | Health & social care | 2022 |
| Siddhartha Enterprise Limited | Health & social care | 2025 |
| Sidibe African Restaurant Limited | Hospitality | 2024 |
| SIDOLART1508 Entertainment Ltd | Hospitality | 2022 |
| Sifa Strategy Limited | Professional & scientific | 2012 |
| Sigma Design Engineering Limited | Professional & scientific | 2014 |
| Sigma Foods UK Ltd | Wholesale & retail | 2023 |
| Signature Home Presentation Ltd | Professional & scientific | 2026 |
| Signature Print Studio Ltd | Manufacturing | 2024 |
| Signet Medics Services Ltd | Health & social care | 2021 |
| Sikafx Limited | Professional & scientific | 2018 |
| Sikyem Healthcare Limited | Health & social care | 2023 |
| Silas Yard Ltd | Wholesale & retail | 2020 |
| Silcri Ltd | Transport & logistics | 2017 |
| Silflor Logistic Ltd | Transport & logistics | 2014 |