| Sayah Logistics Services Limited | Transport & logistics | 2019 |
| Sayah Recovery Services Limited | Wholesale & retail | 2023 |
| Sayah Trading Services Limited | Wholesale & retail | 2014 |
| Sayensi Ltd | Information & communication | 2026 |
| Saygun Catering Limited | Hospitality | 2022 |
| Saygun Limited | Hospitality | 2022 |
| Sayito Wellbeing Services Limited | Health & social care | 2025 |
| SB Property Photography Ltd | Professional & scientific | 2022 |
| SBA Roofing Ltd | Construction | 2021 |
| SBH Consulting Services Ltd | Professional & scientific | 2023 |
| SBK9 Services Ltd | Administrative & support | 2024 |
| SBL Build Ltd | Construction | 2019 |
| SBL Technology Candle Manufacturers Limited | Manufacturing | 2015 |
| SBM Group Ltd | Construction | 2024 |
| SBM Worldwide Aesthetics Ltd | Other services | 2022 |
| Sbma Services Ltd | Professional & scientific | 2023 |
| Sbsugu Ltd | Real estate | 2021 |
| SC Creative Ltd | Manufacturing | 2018 |
| SC Developments & Sons Ltd | Construction | 2021 |
| Scales Group Ltd | Financial services | 2024 |
| Scanlon Solutions Ltd. | Construction | 2026 |
| Scantlebury Manwood | Agriculture & fishing | 1985 |
| Scapolite Limited | Arts & recreation | 2021 |
| Schechinah Consulting Limited | Professional & scientific | 2016 |
| Scholars Place Management Company Limited | Households | 2015 |
| School Lane Rentals Ltd | Real estate | 2022 |
| School Ltd | Education | 2022 |
| SCL Electrical Contractors Limited | Construction | 2021 |
| Scope Healthcare Services Ltd | Health & social care | 2024 |
| Scott & Casey Financial Management Limited | Financial services | 2000 |
| Scott and Sons Investments Limited | Real estate | 2026 |
| Scrubhub Cleaners Limited | Administrative & support | 2025 |
| Sculpt My Skyn Ltd | Health & social care | 2021 |
| SD Driveways Ltd | Construction | 2018 |
| SD Envision Ltd | Transport & logistics | 2021 |
| SD Inspection Systems Limited | Other services | 2023 |
| SD Legal Consultancy Ltd | Professional & scientific | 2026 |
| SD Medical Consult Limited | Health & social care | 2026 |
| SDH Makeup Professionals Limited | Administrative & support | 2019 |
| SDH Ministries Ltd | Other services | 2022 |
| SDK Auto UK Ltd | Wholesale & retail | 2018 |
| Sealsafe Ltd | Construction | 2024 |
| SEB V8 Truck Ltd | Transport & logistics | 2022 |
| SEC Exports Ltd | Construction | 2020 |
| SEC87 Ltd | Manufacturing | 2023 |
| Seck Group Ltd | Administrative & support | 2025 |
| Secura AV Limited | Administrative & support | 2024 |
| Security Jobs and Services Limited | Administrative & support | 2021 |
| Security Systems Integrated Ltd | Construction | 2012 |
| SEE Before YOU TEE Limited | Information & communication | 2025 |
| Seecro Labs Ltd | Manufacturing | 2026 |
| Seed Investment Group Ltd | Real estate | 2019 |
| Seed to Spoon CIC | Hospitality | 2023 |
| Seekay Consultancy Ltd | Professional & scientific | 2025 |
| Sefain Limited | Wholesale & retail | 2020 |
| Segeofi Services Limited | Health & social care | 2014 |
| Segham Consulting Ltd | Professional & scientific | 2016 |
| Seher Rahmatulla Limited | Health & social care | 2023 |
| Selah Music Academy UK Ltd | Education | 2026 |
| Selby Estates and Developments Limited | Real estate | 2018 |
| Seldom Models Limited | Arts & recreation | 2015 |
| Sele House Management Company Limited | Households | 1998 |
| Selective Developments Ltd | Real estate | 2021 |
| Selective Electrics Ltd | Construction | 2023 |
| Seles Pride Ltd | Health & social care | 2015 |
| Selham Court Management Company (Two) Limited | Households | 2003 |
| Selham Court Two (Darwin Close) RTM Company Limited | Households | 2010 |
| Selling Stuff Ltd | Wholesale & retail | 2025 |
| Selova Ltd | Wholesale & retail | 2025 |
| SEM Integrated Services Ltd | Health & social care | 2023 |
| Senator Pens Limited | Wholesale & retail | 1983 |
| Seneca Court Management Limited | Households | 2005 |
| Senigpay Ltd | Administrative & support | 2017 |
| Seniguk Consulting Ltd | Information & communication | 2010 |
| Sepau Ltd | Wholesale & retail | 2020 |
| Sepol Limited | Transport & logistics | 2019 |
| Sequoia Consultancy Limited | Real estate | 2024 |
| Serena Brewster Limited | Wholesale & retail | 2019 |
| Serene Studio Ltd | Other services | 2025 |
| Serenity Consulting Solution Ltd | Transport & logistics | 2023 |
| Serenity Health and Beauty Limited | Other services | 2002 |
| Serenity Heights Ltd | Education | 2024 |
| Serenity Vets Ltd | Professional & scientific | 2025 |
| Serex Ltd | Other services | 2019 |
| Sergeant’S Garage “Celer ET Aubax” RGJ Ltd | Wholesale & retail | 2025 |
| Serogi AI Ltd | Wholesale & retail | 2025 |
| SES Aviation Ltd | Administrative & support | 2020 |
| SES Corporation Ltd | Professional & scientific | 2013 |
| SES Logistics Ltd | Other services | 2023 |
| SES Property Investments Ltd | Extraterritorial | 2004 |
| Sestras Services Ltd | Transport & logistics | 2017 |
| SEV Bar Ltd | Hospitality | 2024 |
| Seven Five Five Design Ltd. | Arts & recreation | 2004 |
| SEW Haulage Limited | Transport & logistics | 2018 |
| SEY London Limited | Professional & scientific | 2015 |
| Seydola Ltd | Health & social care | 2026 |
| Seyi’S Shop Limited | Wholesale & retail | 2020 |
| SF Distributions Ltd | Wholesale & retail | 2025 |
| Sfarr Props Ltd | Information & communication | 2019 |
| SFS Projects Limited | Real estate | 2006 |