| Scott Building Services Limited | Construction | 2007 |
| Scott Homes (Builders) Limited | Administrative & support | 2016 |
| Scott IT Services Ltd | Information & communication | 2019 |
| Scott Little Limited | Construction | 2021 |
| Scott Medical Supplies Ltd | Professional & scientific | 2026 |
| Scott Properties (UK) Limited | Professional & scientific | 2008 |
| Scottish Racing Ltd | Administrative & support | 2000 |
| Scotts Events & Markets Ltd | Wholesale & retail | 2026 |
| SCP Trade Ltd | Professional & scientific | 2020 |
| Screensavers Limited | Professional & scientific | 2009 |
| Screw Caddy Ltd | Professional & scientific | 2023 |
| Scribble Design Limited | Manufacturing | 2009 |
| Scroggie Property Ltd | Real estate | 2024 |
| Scrs (Scotland) Ltd | Wholesale & retail | 2007 |
| SCT Plastering Services Ltd | Construction | 2023 |
| SCUOTTO21 Ltd | Hospitality | 2025 |
| SD Flooring Specialists Limited | Construction | 2023 |
| Sdcm Ltd | Professional & scientific | 2015 |
| SDM Estate Agents Limited | Real estate | 2017 |
| SDM Locum Limited | Health & social care | 2022 |
| SDS Estates Ltd | Real estate | 2018 |
| Seabourn Cruise Line Limited | | 2025 |
| Search for Truth Charitable Trust | Information & communication | 2008 |
| Search for Truth Enterprises Limited | Information & communication | 2008 |
| Secret Sauce Media Ltd | Professional & scientific | 2023 |
| Seery Electrical Ltd | Professional & scientific | 2024 |
| Segton Bar Limited | Hospitality | 2002 |
| SEH Scotland Ltd | Arts & recreation | 2021 |
| Select Bulding, Civils and Utilities Ltd | Construction | 2018 |
| Self Love Club Tattoo Ltd | Arts & recreation | 2022 |
| Sellframe Ltd | Information & communication | 2014 |
| Semitel Limited | Information & communication | 2008 |
| Semple Buchan Financial Management Ltd | Financial services | 2003 |
| Senior Savers Limited | Information & communication | 2018 |
| Sentinel Property Maintenance Ltd. | Real estate | 2025 |
| Serene Mind Therapy Ltd | Health & social care | 2021 |
| Serio JBW Ltd | Real estate | 2023 |
| SES (Scotland) Ltd | Wholesale & retail | 2018 |
| Seven Spice Leicester Ltd | Hospitality | 2017 |
| SEW Fitting Limited | Wholesale & retail | 2019 |
| SEW YOU CAN by KAY Ltd | Manufacturing | 2024 |
| SF17 Limited | Transport & logistics | 2024 |
| Sgasky Relocation Ltd | Hospitality | 2023 |
| SH Estates Ltd | Real estate | 2020 |
| SH Hamilton Fast Foods Ltd | Hospitality | 2025 |
| Shades of Grace Limited | Wholesale & retail | 2022 |
| Shah Enterprises Deals Limited | Wholesale & retail | 2025 |
| Shahid Family Store Limited | Wholesale & retail | 2019 |
| Shahid Stores Hamilton Limited | Wholesale & retail | 2023 |
| Shaikh-Oka Estate Limited | Real estate | 2022 |
| Shake IT Cocktails Ltd | Wholesale & retail | 2025 |
| Shampicks Trading Ltd | Wholesale & retail | 2026 |
| Sharib Limited | Wholesale & retail | 2025 |
| Sharing Angels Ltd | Other services | 2024 |
| Shark Property Investment Limited | Real estate | 2026 |
| Sharles Holdings Ltd | Professional & scientific | 2018 |
| Sharles Ltd | Professional & scientific | 2023 |
| Sharmabcv Ltd | Health & social care | 2019 |
| Shawsburn Developments Limited | Construction | 2005 |
| Shayan Optics Ltd | Financial services | 2024 |
| Shayan Property Ltd | Real estate | 2024 |
| Shearer Holdings Limited | Health & social care | 2009 |
| Sheena Holdings Limited | Administrative & support | 2016 |
| Sheerwave Ltd | Real estate | 2018 |
| Sheilhill Battery Storage Limited | Professional & scientific | 2022 |
| Shel Property Limited | Real estate | 2023 |
| Shell Trust (UK Property) Limited | | 2023 |
| Shell's Kitchen Ltd | Hospitality | 2021 |
| Sherbet DAB Ltd | Extraterritorial | 2024 |
| Shimla Park Limited | Professional & scientific | 1997 |
| Shivparvati Ltd | Real estate | 2019 |
| Shoe Spark Ltd | Administrative & support | 2024 |
| Shop With MRM Ltd | Wholesale & retail | 2025 |
| SHOP19 Ltd. | | 2023 |
| Shoppezone Limited | Wholesale & retail | 2023 |
| Shoreside Limited | Wholesale & retail | 2024 |
| Shorn Salons Ltd | Other services | 2025 |
| Shos Trading Limited | Hospitality | 2025 |
| Shree Leicester Ltd | Hospitality | 2025 |
| Shreesha Hair & Beauty Ltd | Other services | 2022 |
| Shreya PVT Ltd | Health & social care | 2024 |
| Shunfa Ltd | Hospitality | 2024 |
| Sibling Property Solutions Limited | Real estate | 2024 |
| Sienna Interiors Ltd | Other services | 2010 |
| Siennico Ventures Limited | Hospitality | 2017 |
| Sierracol Energy Holder Ltd. | | 2020 |
| Siesta Key Holdings Ltd | Professional & scientific | 2020 |
| SIG PI Ltd | Professional & scientific | 2019 |
| Sigma Style Ltd | Wholesale & retail | 2024 |
| Signal One Ltd | Professional & scientific | 2025 |
| Signature Hair Design Ltd | Other services | 2026 |
| Signimark Ltd | Manufacturing | 2026 |
| Signs Plus Installations Ltd | Professional & scientific | 2024 |
| Signsafe Traffic Ltd | Construction | 2018 |
| Silicon Glen Technology Limited | Wholesale & retail | 1984 |
| Silks (Glasgow) Limited | Wholesale & retail | 2007 |
| Silva & Turner Limited | Professional & scientific | 2025 |
| Silver Birch Interior Contracts Limited | Construction | 2018 |
| Silver Birch Interiors (UK) Ltd. | Construction | 2014 |
| Silver Birch Retail Ltd | Wholesale & retail | 2019 |