| Dragonfly Property Limited | Real estate | 2019 |
| Drakesphere Limited | Wholesale & retail | 1993 |
| Drawisle Limited | Construction | 1975 |
| Dream Tree Day Nursery Ltd | Health & social care | 2023 |
| Drewmark Property Limited | Construction | 2017 |
| Drillerman Racing Ltd | Health & social care | 2014 |
| Drinks Store Ltd | Wholesale & retail | 2025 |
| Drinks Warehouse Plus Home Hardware Ltd | Financial services | 2020 |
| Drive Components Limited | Wholesale & retail | 2001 |
| Drive Time Finance Ltd | Financial services | 2018 |
| Driveology Birmingham Ltd | Education | 2022 |
| Driverz Plus Ltd | Education | 2024 |
| Driveshift Motors Limited | Wholesale & retail | 2026 |
| Drywite Limited | Manufacturing | 1933 |
| DSL Deliveries Ltd | Transport & logistics | 2020 |
| Dsqa Property Management Limited | Real estate | 2025 |
| Dssb Industries Limited | Wholesale & retail | 2020 |
| Dssb Merry Hill Ltd | Wholesale & retail | 2025 |
| DT Coaching UK Ltd | Arts & recreation | 2024 |
| DTB Holiday Homes Ltd | Hospitality | 2022 |
| DTH Contracts Limited | Construction | 2025 |
| Ductbusters (Southern) Limited | Other services | 2018 |
| Ductbusters Holdings Limited | Energy | 2014 |
| Ductbusters Limited | Administrative & support | 1996 |
| Ductfix Ductwork Limited | Wholesale & retail | 2020 |
| Duke & Blue Limited | Administrative & support | 2020 |
| Duncan Jonathan Williamson Limited | Transport & logistics | 2016 |
| Dunstall Park (Tamworth) Residents Management Company Limited | Households | 2019 |
| Dunstanton Holdings Limited | Financial services | 2003 |
| Dunstanton Homes Limited | Construction | 1963 |
| Dutch Garden Supplies Limited | Wholesale & retail | 2006 |
| DWA Performance Limited | Other services | 2018 |
| DY186 Limited | Other services | 2004 |
| Dylan Hartley Limited | Manufacturing | 2022 |
| Dynamicyt Limited | Manufacturing | 2017 |
| Dzine Furnishing Solutions Limited | Professional & scientific | 2003 |
| E and JW Consultants Ltd | Construction | 2025 |
| E Plan Energy Limited | Construction | 2013 |
| E Plan Group Limited | Financial services | 2020 |
| E R Grove & Co Limited | Professional & scientific | 2007 |
| E&H Design Limited | Wholesale & retail | 2026 |
| E.B.C (MPS) Ltd | Manufacturing | 2010 |
| E.B.C. (Services) Limited | Professional & scientific | 1996 |
| E.Millard(Metals)Limited | Water & waste | 1962 |
| Eagle LM Services Ltd | Transport & logistics | 2026 |
| Earlswood Beds Limited | Wholesale & retail | 2017 |
| Eastleigh Construction & Groundworks Ltd | Administrative & support | 2003 |
| Easy BAT Ltd | Transport & logistics | 2015 |
| Easy Floors (UK) Limited | Wholesale & retail | 2007 |
| Easygates Limited | Wholesale & retail | 1995 |
| Easymax Limited | Health & social care | 2018 |
| EBC Asset Finance Limited | Professional & scientific | 1996 |
| EBC Group (UK) Ltd | Manufacturing | 1996 |
| Ebrahim Anaesthetics Limited | Health & social care | 2022 |
| Eccles Tooling Systems Limited | Extraterritorial | 2015 |
| Echelon Construction Limited | Construction | 2023 |
| ECI Construction Ltd | Construction | 2018 |
| Eco Bespoke Joinery Ltd | Manufacturing | 2025 |
| Eco Brain International Ltd | Professional & scientific | 2025 |
| Eco Doors & Joinery Limited | Manufacturing | 2010 |
| Ecodevy Green Delivery Ltd | Wholesale & retail | 2023 |
| Ecoline Developments Limited | Construction | 2018 |
| Economy Products Supplier Ltd | Wholesale & retail | 2017 |
| Ecopart-Uk Ltd | Wholesale & retail | 2025 |
| Eden Asset Group Limited | Real estate | 2020 |
| Edge Groundcare Limited | Arts & recreation | 2020 |
| Edition Arts Ltd | Wholesale & retail | 2019 |
| Edwards MAC Property Consultants Ltd | Real estate | 2014 |
| Edwin Ellis Creative Media Limited | Information & communication | 2015 |
| EFK Performance Ltd | Professional & scientific | 2024 |
| EFM (Halesowen) Limited | Professional & scientific | 2010 |
| Efolder Ltd | Information & communication | 2015 |
| Ehsan's Properties Ltd | Real estate | 2020 |
| Ejvlandscapes Ltd | Administrative & support | 2024 |
| El-Roi Haven Healthcare at Home Ltd | Health & social care | 2026 |
| ELA Real Estate Ltd | Real estate | 2025 |
| Elarm Limited | Administrative & support | 2015 |
| ELE International Instruments Limited | Professional & scientific | 2021 |
| Electro Aerospace Limited | Extraterritorial | 2010 |
| Electro Support Systems Ltd | Manufacturing | 2024 |
| Electronic Wizards Ltd | Information & communication | 2022 |
| Elegant Glaze Ltd | Construction | 2025 |
| Elegant Hands & Beauty Limited | Other services | 2003 |
| ELEMENT45 Limited | Professional & scientific | 2023 |
| ELF Computing Ltd | Information & communication | 2004 |
| Elite Legal Representation Limited | Professional & scientific | 2012 |
| Elite Midlands Ltd | Transport & logistics | 2014 |
| Elite Services Solutions Ltd | Administrative & support | 2025 |
| ELJ Investments LLP | | 2024 |
| Elledd Ltd | Administrative & support | 2017 |
| Ellison Carter Ltd | Real estate | 2017 |
| Ellory Holdings Limited | Real estate | 2022 |
| ELN Properties Ltd | Real estate | 2023 |
| ELR Homecare Ltd | Health & social care | 2015 |
| Elston Enterprise Holdings Limited | Financial services | 2026 |
| Elston Property Ventures Limited | Households | 2024 |
| Elston Sales Consulting Ltd | Professional & scientific | 2024 |
| Eluxia Medical Ltd | Health & social care | 2026 |
| Emaq Enterprise Limited | Real estate | 2017 |
| Embar Ltd | Extraterritorial | 2019 |