| Shaun Muir Leisure Ltd | Hospitality | 2012 |
| Shaun Muir Racing Limited | Hospitality | 2002 |
| Shayra Tech Limited | Wholesale & retail | 2023 |
| Sheridan RR Services Ltd | Construction | 2022 |
| Shevas Holdings Limited | Real estate | 2023 |
| Shoreline Engineering Limited | Manufacturing | 2016 |
| Shoreline Property Limited | Real estate | 2023 |
| Shresham Ltd | Wholesale & retail | 2023 |
| Sibco Engineering Ltd | Professional & scientific | 2010 |
| Sievert Technical Services Ltd | Professional & scientific | 2023 |
| Simon Baxter Limited | Professional & scientific | 2017 |
| SIMPLYWEBSITES55 Ltd | Information & communication | 2026 |
| Skinny Sisters Ltd | Health & social care | 2025 |
| Skyline Building Consultants Ltd | Professional & scientific | 2021 |
| Skylinedata Ltd | Information & communication | 2018 |
| Skylon Aerial & Satellite Specialists Limited | Information & communication | 2014 |
| Smartgage Ltd | Financial services | 2026 |
| SMG Group Solutions Limited | Professional & scientific | 2024 |
| Smokin Joes Catering Ltd | Hospitality | 2021 |
| SMR Performance Limited | Wholesale & retail | 2025 |
| SNM Holdings Limited | Construction | 2018 |
| Sourcedclo Ltd | Wholesale & retail | 2025 |
| Spark Nimbus Limited | Information & communication | 2020 |
| Spencer Electrical (NE) Ltd | Construction | 2020 |
| Spirit Seekers Ltd | Arts & recreation | 2011 |
| SPT Construction Ltd | Construction | 2025 |
| Sround Medical Limited | Health & social care | 2025 |
| Staindale Health & Safety Ltd | Other services | 2022 |
| Star Hire Limited | Manufacturing | 2024 |
| Star Nail & Spa Ltd | Other services | 2022 |
| Steel River Electrics Limited | Energy | 2012 |
| Steel Tree Ltd | Manufacturing | 2025 |
| Stem Play Ltd | Education | 2024 |
| Stephen Oliver Electrical Ltd | Construction | 2022 |
| Sterling Auto Solutions Limited | Wholesale & retail | 2026 |
| Strata Consulting Group Limited | Professional & scientific | 2026 |
| Summerhouse Architects Limited | Professional & scientific | 2014 |
| Sunday Coffee & Kitchen Ltd | Hospitality | 2023 |
| SUNNY168 Ltd | Hospitality | 2023 |
| Superior Experiences Ltd | Administrative & support | 2026 |
| Surich Smiles Ltd | Health & social care | 2025 |
| SW Project Management Services Limited | Professional & scientific | 2021 |
| Swales Paving & Groundworks Ltd | Professional & scientific | 2014 |
| Swales Plastering & Drylining Limited | Construction | 2025 |
| Swales Property Deshaling Ltd | Professional & scientific | 2013 |
| SWT Home Improvements Limited | Construction | 2016 |
| Sykes Engineering Ltd | Professional & scientific | 2026 |
| T P Inspection Services Limited | Professional & scientific | 2017 |
| T P Property Group Ltd | Real estate | 2021 |
| T.E.H Consultancy Limited | Professional & scientific | 2025 |
| T.Wallis Instrumentation Services Ltd | Professional & scientific | 2022 |
| Tasker (London) Limited | Other services | 2011 |
| Tasker (Property Management) Limited | Real estate | 2012 |
| Tasker Developers Limited | Real estate | 2015 |
| Taste of Indian Ltd | Hospitality | 2025 |
| Taylor Training Solutions Ltd | Education | 2017 |
| TB Rigging Limited | Professional & scientific | 2018 |
| Techficient Solutions Ltd | Information & communication | 2025 |
| Tees North East Ltd | Manufacturing | 2016 |
| Tees Services Ltd | Professional & scientific | 2021 |
| Tees Valley Collaborative Enterprises Limited | Education | 2019 |
| Tees Zine Fest CIC | Arts & recreation | 2024 |
| Teesside Document Solutions Limited | Information & communication | 2015 |
| Teesside Engineering & Plant Services Ltd | Professional & scientific | 2020 |
| Teesside Motorhomes Ltd | Administrative & support | 2022 |
| Tempest Trade Services Ltd. | Wholesale & retail | 2023 |
| THE 9 Anchors Ltd | Hospitality | 2017 |
| THE Cleveland Way Redcar and Cleveland Limited | Other services | 2011 |
| THE Cowgirl Club Ltd | Manufacturing | 2023 |
| THE East Cleveland Co-Operative Learning Trust | Education | 2013 |
| THE Hair Hideaway Ltd | Other services | 2024 |
| THE Hideaway Hub Ltd | Administrative & support | 2024 |
| THE Hideaway Restaurant Limited | Real estate | 1990 |
| THE Meal Prep Coach UK Limited | Hospitality | 2024 |
| THE Monk (North East) Limited | Hospitality | 2016 |
| THE North Yorkshire PUB Company Limited | Hospitality | 2005 |
| THE Rewilding Community CIC | Professional & scientific | 2023 |
| THE Salon Redcar Limited | Other services | 2013 |
| THE Ship Westgate Ltd | Hospitality | 2024 |
| THE Total Development Group Limited | Real estate | 2017 |
| THE Trichology Clinic Ltd | Health & social care | 2025 |
| THE Twisted Peel Ltd | Hospitality | 2020 |
| THE Yorkshire Property Agency Limited | Real estate | 2023 |
| Thegleamteam Ltd | Administrative & support | 2025 |
| Thegogroup Gopat Limited | Manufacturing | 2020 |
| Three Fiddles Limited | Hospitality | 2023 |
| Tilly & Co Memorial Jewellery Ltd. | Manufacturing | 2025 |
| Tmpg Ltd | Real estate | 2020 |
| TNT Fitness Limited | Arts & recreation | 2013 |
| Tom's Scuffs & Scratches Ltd | Wholesale & retail | 2019 |
| Top Search Media Limited | Information & communication | 2017 |
| Toro Limited | Other services | 2022 |
| Torquevalues Limited | Information & communication | 2026 |
| TP Barker Consultants Ltd | Health & social care | 2025 |
| Transport Training and Safety Solutions Ltd | Transport & logistics | 2018 |
| TRD Heating Ltd | Construction | 2015 |
| Treloar's Synthetic Surface's Ltd | Construction | 2019 |
| Trusted Redboxer Ltd | Real estate | 2020 |
| TS14 Limited | Administrative & support | 2001 |
| Ttcdc Limited | Health & social care | 2015 |