| Nexas Hub Ltd | Real estate | 2025 |
| NFI Consultancy Ltd | Information & communication | 2026 |
| Niall C Ltd | Construction | 2024 |
| Nick Brundall Solicitors Limited | Professional & scientific | 2018 |
| Nima Services Ltd | Professional & scientific | 2015 |
| North East Garden Rooms Ltd | Manufacturing | 2023 |
| North East Laundry Services Limited | Administrative & support | 2026 |
| North York Moors Tweed Limited | Wholesale & retail | 2025 |
| North Yorks Computers Limited | Information & communication | 2011 |
| Northcote Meats Ltd | Wholesale & retail | 2022 |
| Northgate Renewable Heating Solutions Ltd | Construction | 2015 |
| Northridge Properties Limited | Construction | 2001 |
| Northshore Storage Limited | Mining & quarrying | 2013 |
| Northway Electrics Limited | Construction | 2016 |
| NOT the Corner Shop Ltd | Wholesale & retail | 2026 |
| Novacraft Properties Ltd | Construction | 2023 |
| Nurture Home Group Ltd | Health & social care | 2025 |
| OF Dice and Them CIC | Health & social care | 2026 |
| OLA Offshore Ltd | Professional & scientific | 2016 |
| Oliver's (NE) Limited | Hospitality | 2019 |
| Omhb Services Ltd | Professional & scientific | 2022 |
| Orbis Town Planning Ltd | Professional & scientific | 2012 |
| OVO Studio Ltd | Information & communication | 2019 |
| P Cann Electrical Services Limited | Professional & scientific | 2013 |
| PA Consultancy Services Ltd | Administrative & support | 2023 |
| Panacea Cost Services Ltd | Professional & scientific | 2022 |
| Park Farm (Guisborough) Limited | Professional & scientific | 1995 |
| Park Lane Management Company (Guisborough) Limited(The) | Households | 1984 |
| Parnabyevans Financial Advisers Limited | Financial services | 2014 |
| Parnabyevans Mortgages Limited | Financial services | 2017 |
| Paul Chester & Associates Limited | Professional & scientific | 2007 |
| Paul Cruickshank Security Limited | Wholesale & retail | 2022 |
| Paul Silk Ltd | Administrative & support | 2022 |
| Paulinus Ltd | Construction | 2020 |
| PB Building and Maintenance Limited | Construction | 2023 |
| PB Tank Container Surveyor Limited | Professional & scientific | 2014 |
| PCB Home Installations Ltd | Construction | 2016 |
| Peacock Sports Surfaces Ltd | Construction | 2019 |
| Peelers Court (Guisborough) Management Company Limited | Households | 2002 |
| Peoples Delivery Service Limited | | 2010 |
| Piks Nlin Agriculture Ltd | Agriculture & fishing | 2025 |
| Pizza Marco 1 Limited | Hospitality | 2024 |
| Pizza Roma NE 2 Ltd | Hospitality | 2024 |
| PJW Instrumentation Limited | Professional & scientific | 2007 |
| Placemaker Property Marketing Limited | Professional & scientific | 2019 |
| Playaone Ltd | Wholesale & retail | 2019 |
| Postgate Engineering Services Limited | Other services | 2013 |
| Prabasi Online Market Ltd | Wholesale & retail | 2025 |
| Premier Decor 1990 Limited | Other services | 2013 |
| Primeroute Cabling Ltd | Construction | 2026 |
| Priory Blinds Limited | Extraterritorial | 2010 |
| Priory Flooring & Blinds Ltd | Wholesale & retail | 2011 |
| Priory Geological Services Ltd | Professional & scientific | 2025 |
| Priory Properties (North East) Ltd | Real estate | 2020 |
| Process Group Limited | Extraterritorial | 2022 |
| Property Revival Group Ltd | Real estate | 2026 |
| Purple Poppy Ltd | Professional & scientific | 2026 |
| Pwel International Limited | Administrative & support | 2020 |
| QCS (NE) Ltd | Wholesale & retail | 2015 |
| R & J E Bullock Limited | Real estate | 2023 |
| R & J ELN Limited | Construction | 2014 |
| R & R Bistro Limited | Hospitality | 2025 |
| R B Farm Contracting Ltd | Agriculture & fishing | 2024 |
| R B Farming Ltd | Agriculture & fishing | 2018 |
| Ramms Pubs Limited | Hospitality | 2020 |
| Readman Joinery Limited | Construction | 2016 |
| Reals Reporting Ltd | Information & communication | 2013 |
| Recoil Energy Ltd | Professional & scientific | 2020 |
| Redboxer Developments Limited | Real estate | 2019 |
| Regency Cleaning Ltd | Administrative & support | 2025 |
| Remote Valuation Ltd | Professional & scientific | 2026 |
| Rizers Ltd | Extraterritorial | 2024 |
| RM & K Limited | Construction | 2013 |
| Robinsons Building & Joinery Limited | Construction | 2016 |
| Robinsons Crafted Construction Ltd | Construction | 2025 |
| Rogers Stewart Associates Limited | Real estate | 2007 |
| Roseberry Barber Ltd | Other services | 2020 |
| Roseberry Consultancy Services Ltd | Professional & scientific | 2025 |
| Roseberry Cottages Ltd | Hospitality | 2020 |
| Roseberry Leisure Ltd | Arts & recreation | 2023 |
| RS Minerals Limited | Wholesale & retail | 2008 |
| Rukn AL Mahaa Trading Ltd | Wholesale & retail | 2025 |
| Runswick Hotels Ltd | Hospitality | 2016 |
| Rvré Limited | Wholesale & retail | 2025 |
| RW Design and Sales Limited | Construction | 2024 |
| RYE View Lettings Ltd | Real estate | 2025 |
| RYT Construction Ltd | Construction | 2025 |
| S & K Rusinek Ltd | Manufacturing | 2020 |
| S Mayberry Limited | Transport & logistics | 2008 |
| S R Instrument Services Ltd | Professional & scientific | 2023 |
| Samr Holdings Ltd | Financial services | 2024 |
| SD Muir Holdings Limited | Administrative & support | 2017 |
| Seakay Ltd | Professional & scientific | 2025 |
| Search Consult Services Ltd | Professional & scientific | 2025 |
| SEB Crawford Racing Ltd | Professional & scientific | 2025 |
| Sellerhq Ltd | Information & communication | 2019 |
| Sellstrom Solutions Limited | Financial services | 2017 |
| SFM (NE) Limited | Administrative & support | 2008 |
| SGA Consultancy (Dgsa) Ltd | Professional & scientific | 2019 |
| Sharkys Bar Ltd | Hospitality | 2025 |