| Spaceapps Ltd | Professional & scientific | 2016 |
| Spaceways Storage Limited | Transport & logistics | 2023 |
| Spark Move Ltd | Real estate | 2017 |
| Spark Towers Ltd | Information & communication | 2020 |
| Spark Your Life Ltd | Information & communication | 2020 |
| Sparkle Exterior Cleaning Specialists Limited | Administrative & support | 2019 |
| Sparkling Craft Limited | Wholesale & retail | 2026 |
| Spearcharm Limited | Professional & scientific | 1991 |
| Special Properties Limited | Households | 1983 |
| Speciality Packaging UK Limited | Manufacturing | 2017 |
| Spectacular Skulduggery Ltd | Information & communication | 2020 |
| Spectrum Armour Limited | Professional & scientific | 2025 |
| Speedbird Electricians Ltd | Construction | 2015 |
| Speign UK Ltd | Administrative & support | 2019 |
| Spencer & Spencer Global Limited | Information & communication | 2018 |
| Spencer Petroleum Consulting Ltd | Mining & quarrying | 2022 |
| Spencer Project Services Ltd | Information & communication | 2024 |
| Spheno Labs Ltd | Information & communication | 2026 |
| Sphere Finance Limited | Professional & scientific | 2018 |
| Spice Trolley Ltd | Wholesale & retail | 2024 |
| Spiced Blue Representation Limited | Other services | 2024 |
| Spicy Atelier Ltd | Wholesale & retail | 2023 |
| Spilia Developments Ltd | Professional & scientific | 2015 |
| Spine Back Rack Limited | Wholesale & retail | 2010 |
| Spinocchia Freund Ff&E Limited | Other services | 2018 |
| Spinor Group Ltd | Manufacturing | 2019 |
| Spiritmen Limited | Manufacturing | 2014 |
| Splitz Facilities Limited | Information & communication | 2021 |
| SPM Transport Ltd | Construction | 2016 |
| Spoorthi Digital Ltd | Wholesale & retail | 2025 |
| Sportent Ltd | Professional & scientific | 2005 |
| Sportfact Limited | Arts & recreation | 1994 |
| Sporting Classics Limited | Extraterritorial | 1985 |
| Sporting Insights Limited | Professional & scientific | 2000 |
| Sports Card Central Ltd | Wholesale & retail | 2025 |
| Sports Facility Solutions Ltd | Professional & scientific | 2008 |
| Sports Focus in Schools Limited | Arts & recreation | 2005 |
| Sports Therapy & Wellness Ltd | Administrative & support | 2017 |
| Sportsflite Limited | Professional & scientific | 2022 |
| Sportsflite Technologies Limited | Administrative & support | 2012 |
| Sportsite Ltd | Professional & scientific | 2016 |
| Sportspro PA Limited | Professional & scientific | 2023 |
| Spotler CRM Limited | Information & communication | 1984 |
| Spotler Holdings Limited | Professional & scientific | 2006 |
| Spotler Limited | Information & communication | 2005 |
| Sppe Guildford Limited | Construction | 2015 |
| Spring Financial Group Limited | Information & communication | 2016 |
| Spring Real Estate Partners Limited | Real estate | 2014 |
| Spring Retail Marketing Limited | Professional & scientific | 2010 |
| Springfield Consultancy Ltd | Professional & scientific | 2022 |
| Springfield Decorations and Display Limited | Other services | 1969 |
| Springfield Supplies Limited | Manufacturing | 2002 |
| Springhill Management Limited | Financial services | 2001 |
| Spritzme Ltd | Wholesale & retail | 2026 |
| Spybey & Company Limited | Professional & scientific | 2011 |
| SQ Leasing Ltd | Administrative & support | 2020 |
| SQL IT Limited | Information & communication | 2007 |
| Square Knot Ltd | Health & social care | 2024 |
| Squarewell Partners Limited | Professional & scientific | 2018 |
| Squirrelstay A01 Ltd | Real estate | 2026 |
| Squirrelstay Ltd | Real estate | 2026 |
| SR Jeanes Limited | Construction | 2006 |
| Sraz Ltd | Professional & scientific | 2019 |
| SRE Developments Limited | Construction | 2014 |
| SRE Limited | Professional & scientific | 2005 |
| SRI Kuma Limited | Real estate | 2001 |
| SRI22PSM Marasini Ltd | Hospitality | 2025 |
| SRM Recruitment Limited | Administrative & support | 2016 |
| SRV Garden Services Ltd | Administrative & support | 2025 |
| SSG Consultancy Services Ltd | Professional & scientific | 2017 |
| Sskb Properties Ltd | Real estate | 2025 |
| SSR Scaffolding Limited | Construction | 2025 |
| ST Bazar Ltd | Wholesale & retail | 2025 |
| ST Catherine's Village Hall Limited | Administrative & support | 2002 |
| ST Edmunds House Limited | Administrative & support | 2008 |
| ST Ives Developments Limited | Construction | 2016 |
| ST James Home Caring Limited | Health & social care | 2016 |
| ST John's Street Farncombe Management Limited | Households | 2010 |
| ST Luke's (Guildford) Management Limited | Households | 1995 |
| ST Mark's Pre-School Limited | Education | 2012 |
| ST Mary's House (Holdings) Ltd | Real estate | 2022 |
| ST Petroc Escape Ltd | Hospitality | 2021 |
| ST. Catherine's School, Bramley | Education | 1998 |
| ST. Edmunds Developments Ltd | Real estate | 2001 |
| ST. Georges Heating & Plumbing Specialists Limited | Construction | 2019 |
| ST. Pier Limited | Real estate | 2018 |
| St.Johns Court Management (Brookwood) Limited | Households | 1992 |
| St.Margarets(Guildford)Limited | Households | 1969 |
| St.Mary's House Limited | Real estate | 1952 |
| Stable Horizon Ltd | Information & communication | 2015 |
| Stacks Devon & Somerset Ltd | Real estate | 2020 |
| Stag Media Limited | Professional & scientific | 2017 |
| Stag Packaging Limited | Manufacturing | 2015 |
| Stag Print Services Ltd | Manufacturing | 2001 |
| Standard Industrial Equipment Limited | Administrative & support | 1986 |
| Stankovic Engineering Ltd | Professional & scientific | 2018 |
| Stanley Cant Limited | Information & communication | 2022 |
| Star Advisors Limited | Professional & scientific | 2018 |
| Star Command Ltd | Financial services | 2020 |
| Star Executive Cars Limited | Transport & logistics | 2025 |