| Smart Cars Specialist Limited | Wholesale & retail | 2008 |
| Smart Catering Limited | Real estate | 2002 |
| Smart Enterprise Systems Limited | Information & communication | 2003 |
| Smart Environments Limited | Information & communication | 2022 |
| Smart Manufacturing Technologies Limited | Manufacturing | 2025 |
| Smart Repair DR Ltd | Construction | 2017 |
| Smart Tax and Accountancy Ltd | Professional & scientific | 2018 |
| Smart Tradehub UK Ltd | Wholesale & retail | 2021 |
| Smart Tranche Ltd | Financial services | 2026 |
| Smarter Properties Investment Limited | Financial services | 2024 |
| Smarter Rent Limited | Real estate | 2018 |
| Smash & Crust Limited | Hospitality | 2026 |
| Smashed Burger Express Ltd | Hospitality | 2025 |
| Smerdel Artisan Joinery Ltd | Manufacturing | 2024 |
| Smirk Security Ltd | Information & communication | 2026 |
| Smith Solutions Limited | Education | 2023 |
| Smoith Piri Food UK Ltd | Hospitality | 2023 |
| Smoke Factory UK Limited | Other services | 2009 |
| Smokey Moes Catering Ltd | Hospitality | 2022 |
| SMP Electronics Limited | Manufacturing | 2012 |
| Smugglers ROW Limited | Professional & scientific | 2025 |
| SN Building & Construction Services Ltd | Construction | 2023 |
| Snapdragon Hill Residents Management Co Ltd | Households | 2025 |
| Snare Digital Limited | Construction | 2024 |
| Sneek Films Limited | Arts & recreation | 2012 |
| Snout Ltd | Manufacturing | 2024 |
| Snowdrop Talent Development Limited | Professional & scientific | 2017 |
| Snowglow Games Ltd | Information & communication | 2022 |
| Soalrim Property Holdings Ltd | Financial services | 2014 |
| Soares Martial Arts Ltd | Arts & recreation | 2023 |
| Social Cognition Ltd | Professional & scientific | 2022 |
| Social Housing Invest Limited | Hospitality | 2014 |
| Socius Technologies (IP) Limited | Information & communication | 2018 |
| Socius Technologies (SP) Limited | Information & communication | 2018 |
| Socius Technologies Group Limited | Information & communication | 2020 |
| Socp Consulting Ltd | Administrative & support | 2021 |
| Socp Holdings Ltd | Administrative & support | 2022 |
| Soda Academies Ltd | Arts & recreation | 2024 |
| Sofa to BED Ltd | Extraterritorial | 2010 |
| Software Planet Group Ltd. | Information & communication | 2015 |
| Softworld Solutions Limited | Information & communication | 2007 |
| Soho Consulting International Ltd | Professional & scientific | 2024 |
| Sola Investments Limited | Real estate | 2019 |
| Solar Mgmt Limited | Professional & scientific | 2023 |
| Solar Sisters CIC | Wholesale & retail | 2022 |
| Solar SO Good Ltd | Construction | 2025 |
| Solara Finance Limited | Financial services | 2025 |
| Solarcycle Ltd | Manufacturing | 2022 |
| Sole Solutions Plumbing and Heating Limited | Construction | 2022 |
| Solent View Homes Ltd | Construction | 2021 |
| Solid Compass Ltd | Information & communication | 2019 |
| Solidlines Ltd | Professional & scientific | 2019 |
| Soliton Consulting Limited | Professional & scientific | 2022 |
| Soloman Asset Management Limited | Real estate | 2017 |
| Solomon Bond Limited | Wholesale & retail | 2016 |
| Solomon Private Limited | Financial services | 2025 |
| Solovision Holdings Limited | Financial services | 2026 |
| Solovision Private Limited | Construction | 2025 |
| Solskate Events Limited | Arts & recreation | 2017 |
| Solutions Film Productions Ltd | Professional & scientific | 2022 |
| Solvace Ltd | Information & communication | 2025 |
| Solve Partners Limited | Professional & scientific | 2022 |
| SOM Film Limited | Information & communication | 2026 |
| SOM Home Limited | Wholesale & retail | 2025 |
| Somertons Close (Guildford) Limited | Households | 2003 |
| Somertons Services Ltd | Administrative & support | 2019 |
| Sonals Property Services Ltd | Professional & scientific | 2019 |
| Sonder Investment Ltd | Hospitality | 2021 |
| Sonderlust Trading Limited | Wholesale & retail | 2024 |
| Sophie Leigh-Bankes Limited | Arts & recreation | 2020 |
| Sorcha Textiles Limited | Other services | 2011 |
| Sorisel Ltd | Wholesale & retail | 2023 |
| Sorrel Social Ltd | Financial services | 2024 |
| SOS N1 Truck Repair Ltd | Wholesale & retail | 2024 |
| Soul Food Collective Ltd | Wholesale & retail | 2016 |
| Sounds Engaging Ltd | Information & communication | 2007 |
| Sounds Nice Limited | Professional & scientific | 2023 |
| Soup Box Limited | Manufacturing | 2024 |
| Source Asset Finance Limited | Financial services | 2015 |
| Soutar Solutions Ltd | Administrative & support | 2016 |
| Souter Bros. Ltd | Hospitality | 2019 |
| South Build Solutions Ltd | Construction | 2018 |
| South East Wedding Cars Ltd | Administrative & support | 2026 |
| South West Surrey Association for Mental Health Limited | Health & social care | 2003 |
| Southbank Energy Ltd | Other services | 2022 |
| Southbanks Residents Association Limited | Professional & scientific | 1991 |
| Southbury (Guildford)Residents Association Limited | Households | 1968 |
| Southcity Food Ltd | Wholesale & retail | 2019 |
| Southern Area Brickwork Limited | Construction | 2007 |
| Southern Clocks Limited | Wholesale & retail | 2016 |
| Southern Consortium for Vulnerable Adults CIC | Other services | 2026 |
| Southern Road Property Ltd | Real estate | 2026 |
| Southern Roadmarkings Limited | Extraterritorial | 2025 |
| Southfields Little Explorers Ltd | Education | 2025 |
| Southside Renovations Limited | Construction | 2010 |
| Southway News Ltd | Wholesale & retail | 2025 |
| Southway Stores Limited | Wholesale & retail | 2018 |
| SP Wimbledon Limited | Arts & recreation | 2023 |
| Spa Monster Limited | Wholesale & retail | 2005 |
| Space Connexions Limited | Professional & scientific | 2003 |