| Discoverie Holdings Ltd | Professional & scientific | 1982 |
| Discoverie Management Services Limited | Professional & scientific | 1986 |
| Discoverie Nordic Holdings Limited | Professional & scientific | 2014 |
| Disperse Pharma Limited | Extraterritorial | 2002 |
| Disposable Medical Equipment Ltd | Wholesale & retail | 2001 |
| Disruptive Sensors Ltd | Manufacturing | 2025 |
| Disruptus Ltd | Financial services | 2017 |
| Distilled Bioenergy Limited | Energy | 2024 |
| Distilled Capital Limited | Professional & scientific | 2024 |
| Distilled Partners Limited | Professional & scientific | 2024 |
| Distribook Limited | Administrative & support | 2006 |
| Diva Management Limited | Information & communication | 1998 |
| Divinetiming T&T Ltd | Wholesale & retail | 2023 |
| Divorce Lifeline (UK) Limited | Professional & scientific | 2012 |
| Divorce Lifeline Limited | Professional & scientific | 2014 |
| DJ Henna Limited | Other services | 2022 |
| DJ Judo Academy Ltd | Education | 2024 |
| Djcateringgroup Ltd | Hospitality | 2023 |
| Djgp Group Ltd | Health & social care | 2020 |
| DJO UK Ltd | Wholesale & retail | 2001 |
| DJR Gardens Ltd | Administrative & support | 2020 |
| Djsh Test Consulting Ltd | Information & communication | 2012 |
| DK Atwal Developments Ltd | Real estate | 2024 |
| DK Housing Services Ltd | Real estate | 2026 |
| DK Plumbing & Heating (Guildford) Ltd | Construction | 2021 |
| DKJ Atwal Ltd | Arts & recreation | 2023 |
| DL Landscaping, Gardening and Tree Surgery Limited | Administrative & support | 2012 |
| DL Manse Estates Limited | Real estate | 2023 |
| Dlcm Limited | Professional & scientific | 2026 |
| DLO Hairdressing Limited | Other services | 2016 |
| DMC Enterprises Limited | Professional & scientific | 2017 |
| DMC Logistics Group Ltd | Transport & logistics | 2024 |
| Dmc-Fix Limited | Information & communication | 2012 |
| DMP Global Services Limited | Administrative & support | 2024 |
| DMS Mechanical Limited | Wholesale & retail | 2025 |
| DNA Neuroanalytics Ltd | Professional & scientific | 2023 |
| Dnastream Limited | Information & communication | 2006 |
| Docklands Arts Ship Ltd | Manufacturing | 2021 |
| DOCTORS4DOCTORS Ltd | Health & social care | 2015 |
| Docusave Ltd. | Administrative & support | 1998 |
| Dodo Construction Services Ltd | Construction | 2025 |
| Dog Sky Films Limited | Information & communication | 2022 |
| Dohne Limited | Financial services | 2025 |
| Doing Things Limited | Professional & scientific | 2023 |
| Dokimakis Law Ltd | Professional & scientific | 2025 |
| Dolphin House (Guildford) Limited | Households | 1992 |
| Dolphin Kick Limited | Wholesale & retail | 2013 |
| Dolphin N2 Limited | Professional & scientific | 2017 |
| Donald Watt Associates Limited | Administrative & support | 2010 |
| Donbe Systems Limited | Health & social care | 2014 |
| Doney Consulting Limited | Professional & scientific | 2012 |
| Doniliving Limited | Real estate | 2025 |
| Donna Morgan Counselling Ltd | Health & social care | 2021 |
| Donric Properties Limited | Construction | 2015 |
| Don’T Stop Dreaming Limited | Hospitality | 2024 |
| Doocoe Limited | Real estate | 2019 |
| Doormatic (Chalfont) Limited | Wholesale & retail | 2012 |
| Doormatic Group Holdings Limited | Financial services | 2023 |
| Doormatic Group Limited | Financial services | 2020 |
| Doormatic Limited | Professional & scientific | 2002 |
| Dorina POO Cleaning Ltd | Transport & logistics | 2020 |
| Doris at Ostlers Limited | Other services | 2018 |
| Dorper Holdings Limited | Wholesale & retail | 2025 |
| Dorset and Hampshire Education Limited | Education | 2021 |
| Dorset Medical Limited | Health & social care | 2015 |
| Dorset Premises Ltd | Construction | 2019 |
| Dorset Street Media Limited | Other services | 2022 |
| Dotcom Retail Limited | Professional & scientific | 2007 |
| Dotrew Limited | Information & communication | 2026 |
| Double B Productions Limited | Information & communication | 2015 |
| Double G Studios Limited | Other services | 2007 |
| Double H Design & Build Limited | Construction | 2016 |
| Double R BMS Installation and Maintenance Ltd | Administrative & support | 2017 |
| Doubleverify International, Ltd. | Information & communication | 2021 |
| Doubleverify Ltd | Wholesale & retail | 2010 |
| Douglas Corbett Plant Limited | Construction | 2015 |
| Dova Global Ltd | Wholesale & retail | 2023 |
| Dovebarn Limited | Real estate | 1995 |
| Doves Healthcare Ltd | Professional & scientific | 2011 |
| Dovetail Systems Limited | Information & communication | 2006 |
| Down Forward Punch Ltd | Information & communication | 2023 |
| Down to Earth Concepts Ltd | Construction | 2016 |
| DPC Management Ltd | Real estate | 2024 |
| DPH Carpentry Limited | Construction | 2017 |
| DPR 2022 Limited | Professional & scientific | 2022 |
| DPS Games Limited | Information & communication | 2018 |
| DR Band Clinic Limited | Health & social care | 2021 |
| DR Elinor Sason Psychological Services Limited | Health & social care | 2022 |
| DR House Limited | Construction | 2016 |
| DR J R Glover Radiology Ltd | Health & social care | 2009 |
| DR Karen Morton Ltd | Health & social care | 2012 |
| DR Magdalene Ekpiken Limited | Health & social care | 2009 |
| DR Olenka Dean Limited | Professional & scientific | 2022 |
| DR S Carroll Limited | Health & social care | 2019 |
| DR Sudhir Rathore Limited | Health & social care | 2017 |
| DR. BIB Laboratories Ltd | Manufacturing | 2021 |
| Dragon Roofing Supplies Limited | Wholesale & retail | 1998 |
| Drainageve Ltd | Construction | 2020 |
| Drakeshardflooring Ltd | Construction | 2025 |
| Drawbridge Partners Limited | Information & communication | 2019 |