| DC Electrical (Essex) Limited | Construction | 2021 |
| DCE Holdings Limited | Professional & scientific | 2024 |
| DCT Innovation Ltd | Professional & scientific | 2016 |
| Ddhg Limited | Financial services | 2021 |
| DDK Machine Movers Ltd | Transport & logistics | 2003 |
| DE Beer & Co Ltd | Professional & scientific | 2012 |
| Dead Air Ltd | Arts & recreation | 2024 |
| Dead-Lock Services Ltd | Construction | 2000 |
| Dean Court Residents Management Limited | Households | 1997 |
| Deane Austin Limited | Professional & scientific | 1990 |
| Deanhill Capital Ltd | Professional & scientific | 2018 |
| Debae Studio Limited | Professional & scientific | 2019 |
| Debden Importing (U.K.) Limited | Manufacturing | 1933 |
| Debtback Ltd | Professional & scientific | 2020 |
| Decade Retail Limited | Wholesale & retail | 2011 |
| Decarbonise Fuel Limited | Energy | 2020 |
| Decision Analysis Holdings Limited | Professional & scientific | 2016 |
| Decision Analysis Services Limited | Professional & scientific | 2006 |
| Decoro Design Ltd | Professional & scientific | 2024 |
| Dedomena Consulting Ltd | Professional & scientific | 2016 |
| Dedswell Consultancy Limited | Professional & scientific | 2025 |
| Dedswell Drive Management Limited | Other services | 2000 |
| DEE Taylor Hairdressing Limited | Other services | 2012 |
| Deed Solutions Limited | Information & communication | 2013 |
| Deep C Limited | Professional & scientific | 2007 |
| Deep Cognition Ltd | Extraterritorial | 2006 |
| Deepbluegarlic Ltd | Information & communication | 2024 |
| Deeprose Engineering Ltd. | Real estate | 1990 |
| Defibfest Limited | Arts & recreation | 2022 |
| Dehavilland Hotel & Real Estate Ltd | Construction | 2025 |
| Delightful Shutters Ltd | Wholesale & retail | 2021 |
| Delima Health Ltd | Health & social care | 2022 |
| Delivered Social Ltd | Information & communication | 2016 |
| Delivery Agency Chain Limited | Transport & logistics | 2021 |
| Deltagrowth Limited | Professional & scientific | 2012 |
| Deltatower International Limited | Other services | 2018 |
| Demand and Supply Ltd | Construction | 2013 |
| Demand Marketing Limited | Administrative & support | 2018 |
| Dene Road Management Company Limited | Real estate | 2009 |
| Dentalmatch Recruitment Solutions Limited | Administrative & support | 2015 |
| Denzong Solutions Ltd | Information & communication | 2018 |
| Dera Design & Build Limited | Construction | 2017 |
| Derby Dreamon Ltd | Hospitality | 2020 |
| Derek Arden International Limited | Professional & scientific | 2000 |
| Derero Limited | Professional & scientific | 2012 |
| Derryswood House Management Company Limited | Households | 1998 |
| Design & Management (Holdings) Limited | Professional & scientific | 2000 |
| Design Your Garden Limited | Administrative & support | 2020 |
| Designhive 3D LLP | | 2011 |
| Desmidty's Limited | Professional & scientific | 2024 |
| Desmistificado Limited | Wholesale & retail | 2025 |
| Despatchlab Limited | Information & communication | 2012 |
| Destined 247 African Stores Ltd | Wholesale & retail | 2023 |
| DESTINED247CARE Agency Ltd | Administrative & support | 2023 |
| Destrodent Pest Control Limited | Administrative & support | 2007 |
| Detailed Decorating Limited | Construction | 2022 |
| Deutsch Creative Limited | Professional & scientific | 2003 |
| Develop Talent Ltd | Professional & scientific | 2012 |
| Developing Agency Limited | Professional & scientific | 2013 |
| Devil Trans Ltd | Transport & logistics | 2016 |
| Devote Limited | Professional & scientific | 2007 |
| Devstone Limited | Information & communication | 2026 |
| Dewyderma Aesthetics Ltd | Other services | 2024 |
| DG Aviation Services Ltd | Transport & logistics | 2010 |
| DGD Arts Limited | Administrative & support | 2017 |
| DH Business Psychologist Ltd. | Professional & scientific | 2017 |
| DH Guildford Limited | Real estate | 2021 |
| Dhxsoft Limited | Other services | 2010 |
| Dialogue Psychology Limited | Health & social care | 2016 |
| Diamantidi Developments Ltd | Construction | 2020 |
| Diamond Landscaping (Weybridge) Limited | Administrative & support | 2009 |
| Diamond Logistics Guildford Limited | Extraterritorial | 2021 |
| Diamond Logistics Limited | Transport & logistics | 1997 |
| Diasphere Limited | Information & communication | 2011 |
| Dibya Estates Ltd | Real estate | 2024 |
| Didonne Property Limited | Real estate | 2025 |
| Diecast Legends Limited | Extraterritorial | 2013 |
| Different Pictures Ltd | Professional & scientific | 2011 |
| DIG Deeper Media Limited | Professional & scientific | 2015 |
| Digi Digest Ltd | Professional & scientific | 2020 |
| Digi Tech Repair Ltd | Other services | 2025 |
| Digiprint Supplies UK Limited | Manufacturing | 2017 |
| Digital Design Corporation Limited | Professional & scientific | 1999 |
| Digital Field Modelling Limited | Professional & scientific | 2007 |
| Digital Mirror Ltd | Professional & scientific | 2023 |
| Digital NFP Ltd | Information & communication | 2019 |
| Digital Recognition Limited | Manufacturing | 2015 |
| Digital Smiles Ltd | Health & social care | 2020 |
| Digitally Inspired Ltd | Information & communication | 2014 |
| Digitise Services Limited | Professional & scientific | 2020 |
| DIL & G Fashion Ltd | Wholesale & retail | 2023 |
| Diligents Male Grooming and Well Being Ltd | Other services | 2023 |
| Dinc Cafe 2006 Ltd | Hospitality | 2021 |
| Dinegift Ltd | Hospitality | 2026 |
| Ding's Car Beauty & Paint Ltd | Wholesale & retail | 2023 |
| Direk Ltd | Information & communication | 2017 |
| Disability Challengers | Health & social care | 2001 |
| Discover Archery Ltd | Arts & recreation | 2012 |
| Discoverie Electronics Limited | Professional & scientific | 2008 |
| Discoverie Group PLC | Professional & scientific | 1986 |