| On-Schedule Logistics UK Ltd | Wholesale & retail | 2023 |
| One Integrated Logistics Limited | Administrative & support | 2010 |
| Ophem Luxe Limited | Wholesale & retail | 2025 |
| Optima Bedding Limited | Wholesale & retail | 2008 |
| Oriental Pearl Fastfood Ltd | Hospitality | 2019 |
| Orion X Corp Ltd | Administrative & support | 2019 |
| Otep Technologies Limited | Wholesale & retail | 2009 |
| P & M Homes Limited | Construction | 2001 |
| P & P Investments Limited | Real estate | 2006 |
| P & P Plastering & DRY Lining Contractors Limited | Construction | 1999 |
| Park Court Residents Association (Morecambe) Limited | Households | 1985 |
| Partners in Change Consulting Ltd | Professional & scientific | 2018 |
| Paystream My MAX Limited | Administrative & support | 2007 |
| PC for Reconstruction and Development Ltd | Construction | 2024 |
| Pearce Flooring Ltd | Construction | 2012 |
| Peddle Home Ltd | Wholesale & retail | 2021 |
| Penipride I.E. Limited | Manufacturing | 2002 |
| Peppercorn Insurance Services Limited | Financial services | 2020 |
| Peter Smart Consulting Limited | Professional & scientific | 2010 |
| Peter Thompson Machinery Limited | Wholesale & retail | 2001 |
| Pftf Holdings Limited | Financial services | 2018 |
| Pftf Limited | Financial services | 2015 |
| PH Blinds & Curtains Limited | Manufacturing | 2009 |
| Pink Cloud Health & Beauty Limited | Wholesale & retail | 2017 |
| PJ and JE Orthopaedic Services Limited | Health & social care | 2019 |
| PK Capital Limited | Administrative & support | 2012 |
| Plas Bodegroes Limited | Hospitality | 1988 |
| Plumb Limited | Construction | 1999 |
| Portable Foods Manufacturing Company Limited | Manufacturing | 1998 |
| Powertalk Limited | Wholesale & retail | 1998 |
| Premier Spas (Chesterfield) Ltd | Wholesale & retail | 2012 |
| Prestige Lodges Ltd | Hospitality | 2024 |
| Primevibe Trading Limited | Wholesale & retail | 2026 |
| Professional Remediation Limited | Water & waste | 2009 |
| Promokio Ltd | Wholesale & retail | 2019 |
| Proplexo Limited | Professional & scientific | 2024 |
| PTG Treatments Limited | Manufacturing | 1955 |
| Puddleducks Daycare Limited | Education | 2005 |
| Pyramid Property Services Ltd | Extraterritorial | 2004 |
| Q Crane & Plant Hire Limited | Administrative & support | 1972 |
| QA Investments Ltd | Information & communication | 2020 |
| Quadri OUD & Perfumes Ltd | Manufacturing | 2026 |
| Quality Save (Holdings) Limited | Administrative & support | 2020 |
| Queensbrook Solutions Ltd | Administrative & support | 2016 |
| Quickadora Limited | Extraterritorial | 2020 |
| Quince Tree Trading Limited | Wholesale & retail | 2001 |
| R J Murray Construction Services Ltd | Construction | 2003 |
| R Tinker (Welding Engineers) Limited | Manufacturing | 2003 |
| R.J. Bradley & Sons Limited | Wholesale & retail | 1965 |
| Raveena Properties Limited | Real estate | 2009 |
| RCH Maintenance Limited | Construction | 2020 |
| RDT Construction Limited | Construction | 2003 |
| Red Wolf Software Limited | Information & communication | 2025 |
| Reddish Resources Limited | Information & communication | 2014 |
| Redline Car Group (Leeds) Ltd | Wholesale & retail | 2020 |
| Redwater Investments LLP | | 2009 |
| Redwaters Leisure Limited | Professional & scientific | 2018 |
| Redwaters Strategic Land 3 Ltd | Construction | 2016 |
| Reeve Engineering Limited | Manufacturing | 2006 |
| Refinery Group Limited | Administrative & support | 1982 |
| Regan Peggs Solicitors Ltd. | Professional & scientific | 2017 |
| Regents Court Chorlton RTM Company Ltd | Households | 2022 |
| Rehan Kitchen Ltd | Hospitality | 2022 |
| Reliable Food Service Limited | Wholesale & retail | 2005 |
| Relief RX Ltd | Health & social care | 2023 |
| Render Assistance Limited | Transport & logistics | 2019 |
| Rica Paris Ltd | Wholesale & retail | 2024 |
| Richard Foster Architects Limited | Professional & scientific | 2021 |
| Richardson Engineering Associates Limited | Professional & scientific | 2006 |
| Rimmers of Penny Lane Limited | Wholesale & retail | 2002 |
| RIN Studio Ltd | Professional & scientific | 2025 |
| Riverhill & Leigh Landscape Design & Construction Limited | Other services | 2003 |
| Riverplan Limited | Professional & scientific | 2011 |
| ROB Kerr (Sale) Limited | Wholesale & retail | 1999 |
| Rochdale and District Mind | Health & social care | 1988 |
| Rock Soup Media Ltd | Professional & scientific | 2016 |
| Rophe Limited | Wholesale & retail | 2012 |
| Roselea SAP Consulting Limited | Information & communication | 2007 |
| Rovik Ltd | Wholesale & retail | 2026 |
| RP (Manchester) Limited | Real estate | 2002 |
| RTE Ltd | Construction | 1994 |
| Rusha Ltd | Wholesale & retail | 2025 |
| S & J Kedward Investments Ltd | Real estate | 2002 |
| S.L.O. Food Retail Limited | Wholesale & retail | 2022 |
| Safespark Ltd | Construction | 2015 |
| Salford and Trafford Engineering Group Training Association Limited | Education | 1980 |
| Salford Wellbeing Centre Ltd | Health & social care | 2022 |
| Sanctum Group Holdings Ltd | Financial services | 2026 |
| Sanderson Court (Leigh) Management Company Limited | Hospitality | 1992 |
| Sandiford Management Consultants Limited | Information & communication | 2004 |
| Sanrio UK Finance Limited | Financial services | 2011 |
| Sara Jafari Limited | Health & social care | 2019 |
| Saragusa Frozen Foods Limited | Professional & scientific | 1978 |
| Sass Limited | Wholesale & retail | 2007 |
| Savi Commercial Investments Ltd | Real estate | 2023 |
| Savi Commercial Leasing Ltd | Real estate | 2025 |
| Scapa Group Limited | Professional & scientific | 1964 |
| Scapa Healthcare Limited | Professional & scientific | 2018 |
| SD Psych Ltd | Health & social care | 2015 |
| Seca Projects Limited | Other services | 2018 |