| Dedicated (East Midlands) Community Interest Company | Education | 2019 |
| Deejpt Ltd | Other services | 2021 |
| Deliwraps Limited | Manufacturing | 2009 |
| Delou Limited | Professional & scientific | 2024 |
| Deluxe Driveways & Resin Ltd | Administrative & support | 2026 |
| Demarq Limited | Information & communication | 2014 |
| Demon Cleaning Services Limited | Administrative & support | 2013 |
| Denton House Limited | Administrative & support | 2012 |
| DEO Favente Construction Services Limited | Construction | 2014 |
| Department R Limited | Wholesale & retail | 2025 |
| Descendant Technology Limited | Information & communication | 2024 |
| Design EX Creative Ltd | Professional & scientific | 2025 |
| Desired Landscaping Outdoor Living and Lighting Ltd | Administrative & support | 2026 |
| Devereux Capital LLP | | 2010 |
| Devos Dance & Drama Ltd | Education | 2022 |
| Dexterity Ltd | Financial services | 2025 |
| DG Roofing Slating Tiling and Leadwork Limited | Construction | 2018 |
| DGM Electrical Contractor Limited | Construction | 2013 |
| Dhamnash Ltd | Transport & logistics | 2019 |
| Diamond Nails Grantham Ltd | Other services | 2024 |
| Diamond Spirit Ltd | Wholesale & retail | 2023 |
| Diasporanomics Ltd | Professional & scientific | 2025 |
| Dice Cavern Games Ltd | Wholesale & retail | 2019 |
| Dida Styles & Accessories Ltd | Wholesale & retail | 2020 |
| Dieci Telehandlers Ltd | Other services | 2010 |
| Digby Limited | Hospitality | 2019 |
| Digital Crocodile Limited | Information & communication | 2015 |
| Digital Drums Limited | Administrative & support | 2007 |
| Digital Expanders Limited | Wholesale & retail | 2024 |
| Dimzolon Ltd | Administrative & support | 2021 |
| Dini Properties Ltd | Real estate | 2025 |
| Direct Leisure Supplies Limited | Manufacturing | 1973 |
| Discover Analytics Limited | Administrative & support | 2019 |
| Discovery Summer Group Limited | Financial services | 2021 |
| Dj&K Logistics & Supplychain Consultancy Ltd. | Professional & scientific | 2025 |
| DKA Services LLP | | 2007 |
| DLS Holdings (Grantham) Limited | Financial services | 2021 |
| DLS Innovations Limited | Information & communication | 2017 |
| DLS Investments Limited | Real estate | 2008 |
| DLS Logistics Ltd. | Transport & logistics | 2011 |
| DLS Plastics Limited | Extraterritorial | 2004 |
| DM Holdco Limited | Other services | 2016 |
| DM Opco Limited | Other services | 2016 |
| DM Topco Limited | Other services | 2016 |
| DMT Starobrat Ltd | Transport & logistics | 2025 |
| DMW Electrical Ltd | Construction | 2023 |
| DNN Construction Ltd | Construction | 2026 |
| DNS Brickwork Ltd | Construction | 2016 |
| Dnsvanexpress Ltd | Wholesale & retail | 2019 |
| Dolcar Ltd | Hospitality | 2026 |
| Dolly Estates Ltd | Real estate | 2023 |
| Dolly Investments Ltd | Financial services | 2021 |
| Dolly Wears Ltd | Wholesale & retail | 2019 |
| Domain Services & Management Ltd | Information & communication | 2024 |
| Domestic Bliss Specialist Cleaning Services Limited | Administrative & support | 2024 |
| Donna Devereux ANP Services Limited | Health & social care | 2020 |
| Donne Productions Limited | Information & communication | 2004 |
| Doodles Drawing and Talking Therapy Limited | Health & social care | 2025 |
| Doodlysquat Design Limited | Professional & scientific | 2013 |
| Dorina Ltd | Hospitality | 2025 |
| Double Dragon Underwriting Limited | Financial services | 1999 |
| Double-Loop Leadership Ltd | Professional & scientific | 2013 |
| Dougal Developments Limited | Construction | 2017 |
| Dougie's Cakehole Limited | Hospitality | 2014 |
| Dower Damp Proofing Ltd | Construction | 2022 |
| Dower Stone Ltd | Construction | 2025 |
| DP Online Marketing Limited | Information & communication | 2011 |
| DPS Consultants Limited | Professional & scientific | 1997 |
| DR GKS Company Ltd | Health & social care | 2018 |
| DR Interim Solutions Ltd | Professional & scientific | 2019 |
| DR S Hamlyn Ltd | Real estate | 2019 |
| Draco Construction Ltd | Construction | 2021 |
| Drakes Court Management (Grantham) Limited | Households | 2003 |
| Drams Limited | Real estate | 2013 |
| DRC Electrical Services Ltd | Construction | 2021 |
| DRC Leisure Limited | Arts & recreation | 2024 |
| Dream Experience Limited | Hospitality | 2024 |
| Dream Gardens Stoneware Limited | Wholesale & retail | 2010 |
| Drewery & Wheeldon Valuers & Auctioneers Limited | Professional & scientific | 2007 |
| Drift Homes Ltd | Construction | 2017 |
| Drimpton Ltd | Transport & logistics | 2022 |
| Driven Elite Ltd | Transport & logistics | 2025 |
| Drointon Underwriting Limited | Financial services | 2004 |
| Drop Kerb Services Ltd | Construction | 2024 |
| Druid Underwriting Limited | Financial services | 1997 |
| Drury Builders Ltd | Construction | 2022 |
| Dryfly Underwriting Limited | Financial services | 2005 |
| Dudd Ltd | Extraterritorial | 2024 |
| Dudgrove LLP | | 2008 |
| Dukesbury Garden Rooms Limited | Manufacturing | 2019 |
| Duncan & Toplis Audit Services LLP | | 2023 |
| Duncan & Toplis Group Limited | Financial services | 2023 |
| Duncan & Toplis Kreston Limited | Professional & scientific | 2016 |
| Duncan & Toplis Legal Services Ltd | Professional & scientific | 2018 |
| Duncan & Toplis Limited | Financial services | 2014 |
| Duncan & Toplis Trustees Limited | Professional & scientific | 2016 |
| Dunlop Adventures Limited | Administrative & support | 2003 |
| Dupree Creative Limited | Professional & scientific | 2001 |
| Dupree Digital Limited | Professional & scientific | 2014 |
| Dupree International Limited | Wholesale & retail | 2018 |