| Durham Photography Ltd | Professional & scientific | 2023 |
| DX Fowler Ltd | Administrative & support | 2022 |
| Dyaxis Group Ltd | Professional & scientific | 2025 |
| Dynamics Cleaners Limited | Administrative & support | 2017 |
| Dynamics Domestic Cleaning Services Limited | Administrative & support | 2025 |
| Dysart Plant Limited | Administrative & support | 1975 |
| E Heppolette Haircare Ltd | Other services | 2003 |
| E M Hansford Accountancy Services Ltd | Professional & scientific | 2014 |
| E M P Accident Repair Centre Ltd | Wholesale & retail | 2012 |
| E&P Stothard Plumbing and Heating Ltd | Construction | 2025 |
| E-Ranger Ltd | Wholesale & retail | 2010 |
| E.A.Sheardown & Company Limited | Agriculture & fishing | 1956 |
| E.B. 888 Ltd | Information & communication | 2020 |
| E.H. Camellot Limited | Financial services | 2019 |
| Eagle Green Limited | Health & social care | 2017 |
| Easi-Gas Ltd | Construction | 2020 |
| East Anglia Resources Limited | Extraterritorial | 2008 |
| East Midlands Cooling Services Ltd | Energy | 2020 |
| East Midlands Helicopters Engineering Limited | Manufacturing | 2005 |
| East Midlands Helicopters Limited | Professional & scientific | 1994 |
| East Midlands Hospitality Ltd | Hospitality | 2011 |
| East Midlands Panelling Services Ltd | Construction | 2021 |
| East Midlands Security Services Ltd | Administrative & support | 2026 |
| East Midlands Steel Limited | Wholesale & retail | 2003 |
| East Midlands Transfers Ltd | Transport & logistics | 2024 |
| East Sunrise Limited | Real estate | 2011 |
| Easterntail Ltd | Transport & logistics | 2020 |
| Easton Farm Park Ltd | Arts & recreation | 2024 |
| Eastside Rides Ltd | Wholesale & retail | 2023 |
| EBB Computers Limited | Information & communication | 1988 |
| Eblana Ltd | Administrative & support | 2012 |
| ECA Consulting Limited | Information & communication | 1993 |
| Eckc Ltd | Construction | 2026 |
| Ecoville Limited | Construction | 2023 |
| ED Johnson International Limited | Health & social care | 2023 |
| ED Transport Ltd | Transport & logistics | 2026 |
| Edenham Pre-School Limited | Education | 2007 |
| Edgreensolutions Limited | Manufacturing | 2021 |
| Editorial Photographers UK Limited | Other services | 2007 |
| Ednc Ltd | Information & communication | 2021 |
| EDU Grow Limited | Other services | 2021 |
| Education Recruitment Limited | Administrative & support | 2011 |
| Edwina Brewster HR Consulting Ltd. | Administrative & support | 2014 |
| EFE23 Ltd | Hospitality | 2025 |
| Efficient Portfolio Wealth Limited | Administrative & support | 2022 |
| Efficient Wealth Ltd | Professional & scientific | 2021 |
| EH Motorsports Ltd | Wholesale & retail | 2024 |
| Eighty-Five Design Limited | Arts & recreation | 2013 |
| Eilean Donan Distillery Ltd | Manufacturing | 2025 |
| Eileen Hunter Limited | Financial services | 2014 |
| EL Brickwork Limited | Construction | 2021 |
| Elaine's Taxis Limited | Transport & logistics | 2011 |
| Elbec Limited | Administrative & support | 2004 |
| Elbistan Pizza Limited | Hospitality | 2022 |
| Eldublu Ltd | Wholesale & retail | 2025 |
| Eleanor George Counselling Ltd | Health & social care | 2026 |
| Electrikcollective Ltd | Construction | 2010 |
| Element Marquees Ltd | Arts & recreation | 2025 |
| Elevate Health and Diagnostics Ltd | Health & social care | 2026 |
| Eliant Properties Limited | Real estate | 2024 |
| Elijah Hospitality Ltd | Hospitality | 2023 |
| Elita Ltd | Wholesale & retail | 2015 |
| Elite Cladding and Construction Ltd | Construction | 2020 |
| Elite Equine Transport Ltd. | Transport & logistics | 2017 |
| Elite Hospitality North West Limited | Hospitality | 2024 |
| Elite Joints Limited | Health & social care | 2025 |
| Elite Landscaping Ltd | Administrative & support | 2011 |
| Elite Plus Healthcare Ltd | Health & social care | 2023 |
| Elite Rail Consultants Ltd | Transport & logistics | 2015 |
| Ellany Inns Limited | Hospitality | 2025 |
| Elloe C.I.C. | Wholesale & retail | 2019 |
| ELM Grange Flooring Ltd | Construction | 2012 |
| Elmwood Independent Living Limited | Other services | 2017 |
| Elnry Limited | Financial services | 2014 |
| Elsaime Property Limited | Real estate | 2025 |
| EM Pharmaceutical Ltd | Health & social care | 2026 |
| EM Pro Ltd | Transport & logistics | 2025 |
| Ember & Acre Ltd | Professional & scientific | 2026 |
| Ember Nails Ltd | Other services | 2026 |
| Embittered Limited | Wholesale & retail | 2019 |
| Emerald Stones PVT Ltd | Real estate | 2026 |
| Emess Capital LLP | | 2006 |
| Emms Eyecare Limited | Wholesale & retail | 2018 |
| Emms Group Limited | Financial services | 2018 |
| Emotional Problem Solving Ltd | Education | 2021 |
| Emsley Capital LLP | | 2012 |
| Enabler Compliance Limited | Professional & scientific | 2023 |
| Enarche Ltd | Information & communication | 2026 |
| Enchanted Fables Ltd | Wholesale & retail | 2025 |
| Endeavour Consulting Limited | Professional & scientific | 2025 |
| Engpak Ltd | Wholesale & retail | 2025 |
| Eoaja Healthcare Limited | Health & social care | 2019 |
| Eostrarch Ltd | Wholesale & retail | 2021 |
| EP Holdings Limited | Professional & scientific | 2014 |
| EPL Corporate Investments 2 LLP | | 2007 |
| Equilibrium HWP Holding Limited | Arts & recreation | 2020 |
| Equilibrium HWP Limited | Arts & recreation | 2013 |
| Equilibrium Personal Training Limited | Arts & recreation | 2021 |
| Equine Sports UK Limited | Other services | 2013 |
| ER Express Cleaning Services Ltd | Administrative & support | 2025 |