| Compass Fit OUT NW Ltd | Construction | 2023 |
| Compass IT Limited | Information & communication | 2019 |
| Complete Air Supplies Ltd | Manufacturing | 2019 |
| Complete Car Sales Ashton Ltd | Wholesale & retail | 2025 |
| Complexa HPE Ltd | Professional & scientific | 2020 |
| Complexatools Limited | Manufacturing | 1988 |
| Complink UK Ltd | Other services | 2019 |
| Compound Solutions Ltd | Manufacturing | 2006 |
| Comptable Ltd | Professional & scientific | 2017 |
| Conexum Ltd | Information & communication | 2026 |
| Conflictspro Limited | Information & communication | 2025 |
| Conlin Engineering Ltd | Professional & scientific | 2021 |
| Connect My Car Ltd | Extraterritorial | 2016 |
| Connected Accountancy Limited | Professional & scientific | 2016 |
| Contented Canines Training Ltd | Other services | 2019 |
| Contrackt Solutions Ltd | Professional & scientific | 2015 |
| Cookies & Kreme (Derbyshire) Limited | Hospitality | 2023 |
| Cookson Property (NW) Ltd | Real estate | 2020 |
| Cookson Property Holding Ltd | Real estate | 2020 |
| Copperhead Developments Limited | Construction | 2022 |
| Copperhead GAS Services Ltd | Construction | 2024 |
| Coppice Walk Estates Limited | Real estate | 2025 |
| Corp POR Ltd | Professional & scientific | 2019 |
| Corpak Limited | Manufacturing | 2018 |
| Covefern Limited | Real estate | 1999 |
| Craig Probert Kitchens & Bedrooms Limited | Construction | 2020 |
| Crime Prevention Policing Ltd | Administrative & support | 2025 |
| Criminal Chic Ltd | Manufacturing | 2019 |
| Crocodile Couriers Ltd | Transport & logistics | 2021 |
| Croft H B Limited | Real estate | 1999 |
| Cross Cliffe Engineering Services Limited | Professional & scientific | 2013 |
| Crossfit Glossop Limited | Arts & recreation | 2021 |
| Crossroads Derbyshire Ltd | Other services | 2010 |
| Crown Fire and Security Services Ltd | Administrative & support | 2019 |
| Crown Fire Services Limited | Other services | 2009 |
| Crowton Rowarth Limited | Administrative & support | 2018 |
| Culcheth Car & Van Sales Limited | Wholesale & retail | 2008 |
| Curtis Transport Limited | Transport & logistics | 2023 |
| Custom Cables Direct Limited | Manufacturing | 2023 |
| Cutting Edge Gardening & Landscaping Ltd | Administrative & support | 2024 |
| D Cooper & SON Ltd | Hospitality | 2025 |
| D J B Associates Limited | Administrative & support | 2009 |
| D J Pape & Associates (NW) Limited | Real estate | 2013 |
| D J Pape & Associates Holdings Limited | Other services | 2023 |
| D2D Construction Limited | Construction | 2019 |
| Daily Sudoku Limited | Information & communication | 2005 |
| Damian James Roofing & Building Services Ltd | Construction | 2022 |
| Damobius Limited | Manufacturing | 2008 |
| Damp and Timber Independent Surveys Ltd | Professional & scientific | 2009 |
| Danemoor Property Ltd | Real estate | 2026 |
| Dark Meadows Production Ltd | Professional & scientific | 2022 |
| Dark Peak Books Ltd | Wholesale & retail | 2021 |
| Dark Peak Collective Ltd | Wholesale & retail | 2026 |
| Dark Peak Construction UK Limited | Construction | 2011 |
| Dark Peak Healthcare Ltd | Health & social care | 2023 |
| Dark Peak Photo Community Interest Company | Professional & scientific | 2024 |
| Dark Peak Services Ltd | Financial services | 2021 |
| DAT Kitchen Ltd | Hospitality | 2024 |
| Data Content Reach Cooperative LLP | | 2021 |
| Dave Hallas Ltd | Information & communication | 2016 |
| Davenport Network Solutions Limited | Construction | 2021 |
| David Timperley Interiors Limited | Manufacturing | 2016 |
| Davja Limited | Real estate | 2020 |
| Dawnedge Engineering Limited | Manufacturing | 2005 |
| Daxtecch Limited | Professional & scientific | 2021 |
| DB Training Solutions Ltd | Professional & scientific | 2010 |
| Dbbr Ltd | Hospitality | 2022 |
| DBK Joiners & Builders Limited | Construction | 2024 |
| DBS Accident Repairs Ltd | Wholesale & retail | 2012 |
| DBS Accounting Ltd | Professional & scientific | 2023 |
| DC Recycling Solutions Ltd | Water & waste | 2011 |
| DCA Distributors Limited | Extraterritorial | 2020 |
| DECOR-8 (North West) Limited | Wholesale & retail | 2001 |
| Dehum Limited | Extraterritorial | 2013 |
| Deli on George Street Limited | Administrative & support | 2024 |
| Delpro Limited | Manufacturing | 1975 |
| Delta Computing Limited | Information & communication | 2005 |
| Denita Danielle Ltd | Wholesale & retail | 2017 |
| Denuo Ltd | Energy | 2023 |
| Derbyshire Business Services Limited | Professional & scientific | 2019 |
| Design Lobby Limited | Professional & scientific | 2014 |
| Develop Carpentry Ltd | Manufacturing | 2024 |
| DG28 Management Ltd | Hospitality | 2013 |
| DGT Building Services Limited | Professional & scientific | 2009 |
| Diamond Aesthetics & Beauty (WD) Ltd | Other services | 2024 |
| Dinnex Consulting Limited | Professional & scientific | 2014 |
| Diplomat Business Services Limited | Real estate | 2016 |
| Distant Hills Glossop Limited | Hospitality | 2023 |
| Distant Hills Ltd | Hospitality | 2025 |
| Diverse Cleaning Commercial Ltd | Administrative & support | 2020 |
| Diverse Cleaning Franchise Limited | Professional & scientific | 2022 |
| Diverse Cleaning Residential Ltd | Administrative & support | 2020 |
| Diverse Cleaning Steam Limited | Administrative & support | 2023 |
| Diverse Property Services Cheshire Limited | Administrative & support | 2020 |
| DJP Notable Limited | Administrative & support | 2014 |
| DLB Aeronautical Engineering Services Limited | Professional & scientific | 2012 |
| DMM76 Investments Limited | Real estate | 2022 |
| DMP Leisure Limited | Hospitality | 2024 |
| DMW Contracts Limited | Construction | 2026 |
| Dodd Sheetmetal Limited | Manufacturing | 2011 |