| Smatgroup Ltd | Wholesale & retail | 2026 |
| SME Bridge Ltd | Information & communication | 2026 |
| Smile Guru Ltd | Health & social care | 2023 |
| Smile Windscreens Limited | Wholesale & retail | 1991 |
| Sminclusive Care Ltd | Health & social care | 2022 |
| Smiths Building Limited | Construction | 2009 |
| Snach Healthcare Limited | Health & social care | 2021 |
| Snack Shack Food Wagon Ltd | Hospitality | 2026 |
| Snapdrive Limited | Other services | 2015 |
| Snappac Ltd | Administrative & support | 2026 |
| Snapright Accounting Limited | Professional & scientific | 2010 |
| Snapright Limited | Professional & scientific | 2004 |
| Snapshot: People's Culture, History and Heritage CIC | Education | 2024 |
| Sneaker Scene Ltd | Wholesale & retail | 2021 |
| Sneakers Prep Ltd | Administrative & support | 2025 |
| Sneh & RAJ Limited | Wholesale & retail | 2026 |
| Snowline Engineering Limited | Construction | 2007 |
| Snsn 2025 Limited | Transport & logistics | 2025 |
| Soal Learning CIC | Hospitality | 2023 |
| Soar Trampoline Park Limited | Other services | 2016 |
| Sofa to Go Ltd | Wholesale & retail | 2025 |
| Software of Excellence UK Holdings Limited | Information & communication | 2008 |
| Soil-Up Limited | Construction | 2019 |
| Soiltec Laboratories Limited | Professional & scientific | 1995 |
| Soky Healthcare Limited | Health & social care | 2018 |
| Sola Fide Properties Limited | Real estate | 2025 |
| Solaify Real Estate Ltd | Real estate | 2024 |
| Solaify UK Ltd | Public administration | 2021 |
| Solarscoutuk Ltd | Professional & scientific | 2026 |
| Solgee Ltd | Manufacturing | 2012 |
| Solid State Educational Solutions Limited | Professional & scientific | 2013 |
| Solutionlinksuk Ltd. | Health & social care | 2021 |
| Songchen Steel Co., Ltd | Manufacturing | 2022 |
| Songline Ltd | Agriculture & fishing | 2025 |
| Sophesc Limited | Wholesale & retail | 2019 |
| Sort My Credit Ltd | Other services | 2020 |
| Soundproofing Shop Limited | Wholesale & retail | 2022 |
| Source Automation Ltd | Information & communication | 2024 |
| South Central Fire and Rescue Limited | Public administration | 2025 |
| South East Access Specialists Scaffolding Contractors Limited | Administrative & support | 2008 |
| South East BTL Properties Ltd | Real estate | 2019 |
| South East Cars & Commercials Ltd | Wholesale & retail | 2022 |
| South East Doors Online Ltd | Construction | 2020 |
| South East Kent Ambulance Service Ltd | Health & social care | 2023 |
| South East Painting & Decorating Ltd | Other services | 2020 |
| South East Region Amateur Gymnastics Association Limited | Arts & recreation | 2021 |
| South East Warmair Solutions Ltd | Construction | 2026 |
| South Essex TPS (2015) Limited | Wholesale & retail | 2015 |
| South Street (Crewkerne) Ltd | Construction | 2021 |
| South West Land Management Limited | Construction | 2018 |
| South West Luxe Glamping Ltd | Hospitality | 2026 |
| South West Optometrists Ltd | Health & social care | 2011 |
| South West Packaging Holdings Limited | Professional & scientific | 1995 |
| South West Packaging Limited | Manufacturing | 1984 |
| Southbridge Services Ltd | Construction | 2019 |
| Southcon Ecom Hub Ltd | Wholesale & retail | 2025 |
| Southern Boiler Spares Limited | Wholesale & retail | 2002 |
| Southern Print Services (SE) Ltd | Manufacturing | 2021 |
| Southern Print Services Ltd | Manufacturing | 2018 |
| Southern Salt Supplies Ltd | Wholesale & retail | 2010 |
| Sovacollection Limited | Professional & scientific | 2008 |
| Sovereign & Commercial Risk Associates Ltd. | Financial services | 2025 |
| Sovereign Quarter (Gillingham) Management Company Limited | Households | 2007 |
| SP Site Engineering Ltd | Professional & scientific | 2015 |
| Sparcc Trading Ltd | Wholesale & retail | 2025 |
| Sparco Group Ltd | Construction | 2015 |
| Spark Consulting Services London Ltd | Professional & scientific | 2025 |
| Sparkling Pearls Ltd | Health & social care | 2025 |
| Sparks Away Ltd | Construction | 2023 |
| Spartan Transport Group Ltd | Wholesale & retail | 2025 |
| SPE Architectural Ltd | Professional & scientific | 2026 |
| Speaking Numbers Limited | Professional & scientific | 2020 |
| Special FR8 Europe Limited | Information & communication | 2009 |
| Spectrum 20 CIC | Education | 2025 |
| Spectrum Healthcare Support Limited | Health & social care | 2024 |
| Spekes Engineering Services Limited | Professional & scientific | 2021 |
| Spendl Solutions Ltd | Real estate | 2019 |
| Spenward Limited | Administrative & support | 2009 |
| Spettro Ltd | Professional & scientific | 2025 |
| Spice Twydall Ltd | Hospitality | 2025 |
| Spiff Improvements Ltd | Construction | 2020 |
| Spirits Sense Limited | Manufacturing | 2020 |
| SPL Epping Ltd | Real estate | 2023 |
| SPL Investments (London) Ltd | Real estate | 2023 |
| Splahdem Ltd | Manufacturing | 2021 |
| Sport on Your Doorstep CIC | Education | 2019 |
| Sports Family Office Ltd | Extraterritorial | 2017 |
| Sprayline Furniture Finishes Ltd | Other services | 2011 |
| Spring Medway Ltd | Hospitality | 2022 |
| Sprites Woodland Nursery Limited | Arts & recreation | 2014 |
| SPS Connect Ltd | Real estate | 2025 |
| SPS Print & Embroidery Services Ltd | Manufacturing | 2025 |
| Spyhill Projects Ltd | Construction | 2022 |
| Square Anvil Limited | Extraterritorial | 2019 |
| Sqwm Ltd | Professional & scientific | 2021 |
| Sqwmi Ltd | Financial services | 2024 |
| SR Cabs Ltd | Transport & logistics | 2026 |
| Sree Housing Group Limited | Real estate | 2026 |
| SRG Sports Performance Limited | Other services | 2014 |
| SRJ Wattridge Limited | Construction | 2019 |