| Sholat Ltd | Health & social care | 2014 |
| Shop Valley Limited | Wholesale & retail | 2018 |
| Shoplyst Limited | Wholesale & retail | 2025 |
| Short Street Garage Ltd | Wholesale & retail | 2020 |
| Show ME Improvement Limited | Professional & scientific | 2025 |
| Shree Aadhya Services Limited | Construction | 2023 |
| Shreeji Foods & Services Ltd | Manufacturing | 2024 |
| Shreeji Services Ltd | Construction | 2019 |
| SHS Plumbing & Heating Ltd | Construction | 2016 |
| SHS Plumbing Heating & Cooling Ltd | Construction | 2025 |
| Shukla Limited | Information & communication | 2001 |
| Shunliall Trading Limited | Manufacturing | 2024 |
| Shunlong International Trading Co., Limited | Manufacturing | 2019 |
| Shuttersufit Limited | Wholesale & retail | 2022 |
| SIA Haulage Ltd | Transport & logistics | 2025 |
| Sights Group Ltd | Administrative & support | 2017 |
| Sigma Chemical Company Limited | Manufacturing | 1963 |
| Sigma Outsourcing Ltd | Professional & scientific | 2023 |
| Sigma-Aldrich Company Limited | Manufacturing | 1987 |
| Sigmaster Ltd | Wholesale & retail | 2026 |
| Signature Technical Services Ltd | Professional & scientific | 2010 |
| Signs & Imaging (South East) Ltd | Administrative & support | 2013 |
| Signs & Sunflowers Limited | Other services | 2023 |
| Sijin Global Limited | Transport & logistics | 2021 |
| Silotechnology Ltd | Arts & recreation | 2026 |
| Silton Investments Limited | Agriculture & fishing | 2011 |
| Silver Dawn Holdings Ltd | Financial services | 2023 |
| Silver Sea Delight Limited | Hospitality | 2025 |
| Silverdale Assets & Investments Ltd | Information & communication | 2023 |
| Silvermere Supplies Ltd | Wholesale & retail | 2015 |
| Silveroak 3D Limited | Professional & scientific | 2020 |
| Silveroak Construction Limited | Construction | 1996 |
| Silveroak Contracting Limited | Construction | 2005 |
| Silveroak Decorators Limited | Professional & scientific | 2010 |
| Silveroak Group Limited | Construction | 2018 |
| Silveroak Procurement Limited | Other services | 2019 |
| Silveroak Properties Limited | Construction | 2000 |
| Silverside Properties Limited | Professional & scientific | 2009 |
| Silverway Productions Ltd | Information & communication | 2026 |
| SIM Motorsport Ltd | Arts & recreation | 2019 |
| SIM Stylez Barber Ltd | Other services | 2024 |
| Simadek Property Ltd | Manufacturing | 2022 |
| Simary's Limted Company Ltd | Public administration | 2019 |
| Simon Drywall Limited | Construction | 2014 |
| Simon Parker Pilates Ltd | Other services | 2024 |
| Simon Wangoto Limited | Health & social care | 2014 |
| Simple Books Limited | Professional & scientific | 2010 |
| Simplicity Records Ltd | Information & communication | 2014 |
| Simply Plastering (UK) Ltd | Construction | 2011 |
| Simply Stay Serviced Accommodation Limited | Real estate | 2022 |
| Simpson Properties 12 Limited | Real estate | 2023 |
| SIN 2026 Ltd | Transport & logistics | 2026 |
| Singh Balwinder Ltd | Wholesale & retail | 2025 |
| Singh Fleet Services Limited | Transport & logistics | 2017 |
| Singh Lettings Ltd | Real estate | 2020 |
| Singlewell Locum Services Limited | Health & social care | 2017 |
| Sino Grand Industrial Ltd | Wholesale & retail | 2022 |
| Sinocarbon Industry Co., Ltd | Wholesale & retail | 2023 |
| Sinosource Supply Chain Group Co., Ltd | Manufacturing | 2024 |
| Sinotruk Commercial Truck Sales Co., Limited | Wholesale & retail | 2025 |
| Sinotruk Group Jinan Truck Co., Ltd | Manufacturing | 2022 |
| Sinotruk International Sales Co., Ltd | Wholesale & retail | 2022 |
| Sinotruk Jinan Special Truck Co., Ltd | Wholesale & retail | 2023 |
| Sinotruk Jinan Special Vehicle Co., Ltd | Extraterritorial | 2017 |
| Sinus Commerce LLP | | 2012 |
| SIR Ceilings Ltd | Construction | 2016 |
| Sirius Business Ltd | Professional & scientific | 2008 |
| Sirius Distribution Ltd | Wholesale & retail | 2010 |
| Site Hoarding Holdings Limited | Financial services | 2024 |
| Site Hoarding Solutions Limited | Construction | 2019 |
| Site Sculptors Ltd | Professional & scientific | 2025 |
| Sixty Three Management Company Limited | Real estate | 2018 |
| SJ Agri Ltd | Agriculture & fishing | 2014 |
| SJ Law Consultant Limited | Professional & scientific | 2016 |
| SJC Property Partners Ltd | Hospitality | 2026 |
| Skarter Limited | Manufacturing | 2025 |
| Skin by Lilly Limited | Other services | 2026 |
| Skin Wealth Aesthetics Ltd | Education | 2025 |
| Skinner Street Pizza & Kebab Ltd | Hospitality | 2025 |
| Sky Legend Services Limited | Administrative & support | 2023 |
| Skylark Hotels Limited | Hospitality | 2012 |
| Skyline Building Developments Ltd | Construction | 2025 |
| Skyline Supported Living Ltd | Health & social care | 2020 |
| Skyway Telecommunications Ltd | Wholesale & retail | 2025 |
| SL Vanish Ltd | Administrative & support | 2023 |
| Slater & Mayes Drywall Solutions Ltd | Construction | 2014 |
| Slimzie Beauty Home Ltd | Other services | 2025 |
| Sliver Solar Solution Ltd | Construction | 2025 |
| SLJ Business Solutions Ltd | Professional & scientific | 2026 |
| SM Property Group Ltd | Real estate | 2017 |
| SM Medical Consultancy Services Ltd | Professional & scientific | 2018 |
| Smart Auto Spa - Gill Ltd | Wholesale & retail | 2025 |
| Smart Auto Spa Ltd | Wholesale & retail | 2023 |
| Smart Choice Auto Repairs Ltd | Manufacturing | 2025 |
| Smart Granny Ltd | Wholesale & retail | 2024 |
| Smart Life Technology Co., Ltd | Wholesale & retail | 2020 |
| Smart Shop High Street Ltd | Wholesale & retail | 2026 |
| Smart Surveying Services Ltd | Construction | 2017 |
| Smartpipe Ltd | Information & communication | 2026 |
| Smartsave Superstore Ltd | Wholesale & retail | 2025 |