| Simon Hammond Wall & Floor Tiling Ltd | Construction | 2016 |
| Siriusly Good Ltd | Manufacturing | 2026 |
| Sixup Rentals Ltd | Real estate | 2025 |
| Sjscv Ltd | Real estate | 2024 |
| Sk-Qa Ltd | Professional & scientific | 2020 |
| Skuytercliff Limited | Information & communication | 2015 |
| Skymua Ltd | Hospitality | 2025 |
| Smart Data Solutions Limited | Information & communication | 2015 |
| Sophie's Groom Room & Hydrotherapy Centre Ltd | Professional & scientific | 2004 |
| Sound Ears Ltd | Health & social care | 2023 |
| Southerngfx Limited | Arts & recreation | 2010 |
| Spectrum Steel Frame Ltd | Construction | 2026 |
| Spencer Rental Properties Limited | Real estate | 2025 |
| Spiro Control Ltd | Professional & scientific | 2012 |
| Squire Properties Limited | Real estate | 2026 |
| Sspg Events Limited | Administrative & support | 2023 |
| Sspg Limited | Other services | 2004 |
| Start Local Think Global Ltd | Manufacturing | 2025 |
| Stbls Limited | Professional & scientific | 2026 |
| Stellivox Ltd | Information & communication | 2026 |
| Stewart and Antrobus Limited | Real estate | 1988 |
| Stoney Stretton Physiotherapy Limited | Health & social care | 2011 |
| Stormtroopers Limited | Manufacturing | 2003 |
| Storysounds Ltd | Education | 2025 |
| Street Solve CIC | Professional & scientific | 2022 |
| Strive Barber Ltd | Other services | 2020 |
| Strive INK Ltd | Administrative & support | 2022 |
| Stronghold Integrated Protective Services Limited | Administrative & support | 2025 |
| Stuart Cryer Associates Ltd. | Professional & scientific | 2018 |
| Stuart Hale Limited | Health & social care | 2023 |
| Studio Curated Ltd | Real estate | 2023 |
| Studio Summon Ltd | Arts & recreation | 2015 |
| Suncastle Limited | Other services | 2026 |
| Super Human Corp Ltd | Wholesale & retail | 2025 |
| Super One Series Limited | Arts & recreation | 2000 |
| Sustainable Woodchip Ltd | Agriculture & fishing | 2021 |
| Swiftlab Ltd | Information & communication | 2016 |
| Swim for ALL Limited | Arts & recreation | 2021 |
| Synergy Gutter Cleaning Limited | Manufacturing | 2025 |
| Syntentia Limited | Information & communication | 2004 |
| Tandy Traffic Management Solutions Ltd | Construction | 2024 |
| Task Aide Ltd | Administrative & support | 2025 |
| Task Management (UK) Ltd | Information & communication | 1996 |
| Team Maintenance UK Limited | Administrative & support | 2016 |
| Team Roundhouse Ltd | Construction | 2013 |
| TEM Holdings Ltd | Administrative & support | 2018 |
| Terraffix Soil Solutions Ltd | Administrative & support | 2019 |
| Teuthill Leisure Limited | Arts & recreation | 2021 |
| THE Bourne (Frodsham) Management Company Limited | Administrative & support | 2014 |
| THE Candy Club Ltd | Wholesale & retail | 2025 |
| THE Cats Abode Ltd | Manufacturing | 2022 |
| THE Chocolate Consultant Ltd | Professional & scientific | 2016 |
| THE Friends of Harmers Wood Trust | Agriculture & fishing | 2005 |
| THE Frodsham Tyre Company Limited | Wholesale & retail | 2003 |
| THE Good Cause Project Ltd | Professional & scientific | 2021 |
| THE Green DC Limited | Manufacturing | 2017 |
| THE Hive Cheshire CIC | Hospitality | 2026 |
| THE Manx Mann Limited | Real estate | 2019 |
| THE Northern Ledger Ltd | Professional & scientific | 2025 |
| THE Recommendation Engine Ltd | Information & communication | 2026 |
| THE Reel Deal Fishing Shop Ltd | Wholesale & retail | 2025 |
| THE Renegade Group Limited | Manufacturing | 2021 |
| THE Retreat Standards Organisation Ltd | Other services | 2025 |
| THE Secret Academy Clinic Ltd | Other services | 2023 |
| THE Stunt Alliance Ltd | Information & communication | 2024 |
| THE Verified Group Ltd | Transport & logistics | 2025 |
| THE Vintage Teapot Tearoom Family Room and Bar Ltd | Hospitality | 2020 |
| Think Smart Services Ltd | Administrative & support | 2019 |
| Thompson Group Holdings Limited | Financial services | 2025 |
| Three Phase Property Ltd | Real estate | 2014 |
| TIM Shovelton Landscapes Limited | Administrative & support | 2019 |
| Tiny Tails Pets Services Ltd | Agriculture & fishing | 2025 |
| Tixr Ltd | Wholesale & retail | 2025 |
| TJM Decorators Ltd | Construction | 2017 |
| TJS Garden Services Limited | Administrative & support | 2019 |
| TJS Grounds Maintenance Limited | Administrative & support | 2019 |
| Tolerence Engineering Limited | Construction | 2005 |
| Tomica Ltd | Information & communication | 2017 |
| Top Taste Food Ltd | Hospitality | 2025 |
| Total Case Management Limited | Health & social care | 2005 |
| Total Selling Ltd | Professional & scientific | 2019 |
| Trades 4 ME Ltd | Information & communication | 2012 |
| Tradiecard Ltd | Financial services | 2025 |
| Tranquil Life Consultancy Ltd | Professional & scientific | 2017 |
| Travel Dajomer (2010) Limited | Transport & logistics | 2010 |
| Travellab Retail Ltd | Administrative & support | 2018 |
| TRG Holdings Global Ltd | Financial services | 2019 |
| TRG Infrastructure Ltd | Construction | 2024 |
| Trisect Management Limited | Hospitality | 2006 |
| TTJ Ltd | Transport & logistics | 2015 |
| TWELVE50 Bikes Limited | Wholesale & retail | 2007 |
| Twig Trading Limited | Administrative & support | 2002 |
| Twinbro Investments Limited | Financial services | 2013 |
| Twinergetic Ltd | Real estate | 2020 |
| Twinicity Ltd | Wholesale & retail | 2015 |
| Twinkle Prints Ltd | Wholesale & retail | 2025 |
| Twinwire Media Ltd | Information & communication | 2018 |
| Twisted Smile Ltd | Manufacturing | 2020 |
| Tying the Knot Ltd | Information & communication | 2004 |
| Tyre King Ltd | Wholesale & retail | 2012 |