| Pelling Limited | Professional & scientific | 1990 |
| Pellings LLP | | 2007 |
| Perfect Floors and Interiors Ltd | Wholesale & retail | 2016 |
| Peter Corcoran Photography Ltd | Professional & scientific | 2010 |
| Pharmassisted Jobs Ltd | Administrative & support | 2024 |
| Phoenix Change Limited | Information & communication | 2022 |
| Pilling Electrical Services Ltd | Construction | 2024 |
| PIP and Poppy Creations Ltd | Manufacturing | 2023 |
| PJB Retail Ltd | Wholesale & retail | 2021 |
| Platform Three Frodsham Ltd | Real estate | 2025 |
| Plexus Investments Limited | Administrative & support | 2003 |
| Plover Trading Ltd | Wholesale & retail | 2022 |
| PLP Estates Limited | Real estate | 2017 |
| Pmrx Limited | Administrative & support | 2015 |
| Port Medical Solutions Ltd | Professional & scientific | 2021 |
| Powers Towers Ltd | Real estate | 2019 |
| Powersuk Ltd | Professional & scientific | 1998 |
| PPP Systems Limited | Information & communication | 2016 |
| Premier Clinical Care Ltd | Health & social care | 2010 |
| Premier Stonework Limited | Other services | 2006 |
| Prescott's of Frodsham Ltd | Wholesale & retail | 2026 |
| Pro Mediate (UK) Limited | Professional & scientific | 2014 |
| Proability Ltd | Professional & scientific | 2011 |
| Prochem International Limited | Manufacturing | 1981 |
| Project Milner Limited | Professional & scientific | 2013 |
| Property Rocks Cheshire Limited | Real estate | 2017 |
| PT Ithell Plant Hire & Demolition Limited | Administrative & support | 2003 |
| Purple Commercial Limited | Real estate | 2019 |
| QR Remembered Limited | Other services | 2017 |
| Quads of UK Ltd | Manufacturing | 2024 |
| Quality Systems & Business Consultants Ltd | Administrative & support | 2011 |
| Queeus Ltd | Professional & scientific | 2025 |
| R & O Healthcare Limited | Health & social care | 2015 |
| R & V Nuttall Limited | Hospitality | 2016 |
| R Hodge Services Ltd | Construction | 2015 |
| R J Moore Limited | Real estate | 2002 |
| R&A Kimpton Ltd | Agriculture & fishing | 2023 |
| Raeann Ltd | Real estate | 2025 |
| Rareqv Ltd | Professional & scientific | 2025 |
| Raylen Associates Ltd | Real estate | 1999 |
| RBG Events Ltd | Arts & recreation | 2019 |
| Read Advisory Global Ltd | Professional & scientific | 2026 |
| Rebel's (Chester) Limited | Wholesale & retail | 2008 |
| Recoverlution Ltd | Information & communication | 2020 |
| Redash Consulting Ltd | Information & communication | 2018 |
| Reelhaus Ltd | Professional & scientific | 2026 |
| Refined Retirement Solutions Ltd | Financial services | 2015 |
| Regal Relocations Ltd | Real estate | 2024 |
| Regis Palmer Group Ltd | Other services | 2025 |
| Renegade Construction Limited | Water & waste | 2023 |
| Reprotocol Limited | Professional & scientific | 2022 |
| Republic Bar Co Ltd | Hospitality | 2019 |
| Retro-Matic Limited | Arts & recreation | 2011 |
| Ringers Frodsham PUB Co Ltd | Hospitality | 2026 |
| Riverside Garage Frodsham Ltd | Wholesale & retail | 2026 |
| RLG Limited | Professional & scientific | 2019 |
| RMS Retail JMJ Ltd | Wholesale & retail | 2025 |
| Roach Realty Ltd | Administrative & support | 2024 |
| Robert Gleave and Sons Limited | Wholesale & retail | 1946 |
| Robert Mackenzie Associates Ltd | Professional & scientific | 2011 |
| Rodgers Carpets Limited | Wholesale & retail | 2001 |
| Rookery Bloodstock Limited | Arts & recreation | 2024 |
| Rosemere Residential Limited | Real estate | 2025 |
| Rosie Weldon Limited | Information & communication | 2020 |
| Roys Relics Limited | Wholesale & retail | 2014 |
| RS Holdings 888 Limited | Real estate | 2019 |
| RSK Acoustics Limited | Professional & scientific | 2009 |
| RSK Biocensus Limited | Professional & scientific | 2002 |
| RSK Hi-Line Limited | Water & waste | 2021 |
| RSK Radiological Limited | Professional & scientific | 2007 |
| RSK Utility Consulting Limited | Professional & scientific | 2018 |
| RTD Property Developments Ltd | Real estate | 2019 |
| RTD Surveys Ltd | Professional & scientific | 2023 |
| Rushies Personal Care Ltd | Health & social care | 2026 |
| RW Welding Ltd | Construction | 2024 |
| S & G Lightfoot Limited | Hospitality | 2021 |
| S J Nixon Limited | Transport & logistics | 2006 |
| S Martin Properties Limited | Real estate | 2018 |
| S W Mechanical Services Limited | Manufacturing | 2025 |
| S-A Recycling Limited | Water & waste | 2011 |
| S.P.B. Properties Limited | Real estate | 1998 |
| S4G Industries Limited | Professional & scientific | 2019 |
| SAB Medical Solutions Ltd | Health & social care | 2016 |
| Sacred Wind Productions Ltd | Information & communication | 2014 |
| Safeshield Pest Prevention Limited | Administrative & support | 2025 |
| Saxon 27 Investments Ltd | Real estate | 2019 |
| Scaffgard Limited | Manufacturing | 2026 |
| Scorpio Builders (N.W. Cheshire) Ltd | | 1961 |
| Scourged Empire Ltd | Wholesale & retail | 2025 |
| Sean Sharkey Courier Services Ltd | Transport & logistics | 2022 |
| Searletec Limited | Construction | 2018 |
| Sebedited Ltd | Transport & logistics | 2025 |
| Semolina Pilchard Film Limited | Information & communication | 2026 |
| Shark Architecture Limited | Professional & scientific | 2025 |
| Shellway Investments Ltd | Real estate | 2016 |
| Sheq Consultancy Limited | Administrative & support | 2012 |
| Sierra Group Holdings Ltd | Financial services | 2025 |
| Signtools UK Ltd | Administrative & support | 2004 |
| Silk & Soul Ltd | Hospitality | 2025 |
| Silverdale Legal Services Limited | Professional & scientific | 2020 |