| Sizian Civils & Construction Ltd | Construction | 2025 |
| SJB50 Limited | Hospitality | 2022 |
| Sjw&Co Ltd | Wholesale & retail | 2019 |
| SKB Management Services Limited | Professional & scientific | 2015 |
| Skools OUT (Fleetwood) Limited | Education | 2009 |
| SLD Electrical Services Ltd | Construction | 2013 |
| SM Investment Partners Ltd | Other services | 2024 |
| Smart Choice Metering Limited | Financial services | 2019 |
| Smart Information Technologies Group Ltd | Financial services | 2021 |
| Smart Information Technologies Limited | Information & communication | 2010 |
| Smart IT (Midlands) Limited | Information & communication | 2023 |
| Smiths Plastering and Tiling Limited | Construction | 2016 |
| Solar Lettings Ltd | Real estate | 2024 |
| Solutions Childcare Limited | Health & social care | 2024 |
| Spartan Communications Limited | Information & communication | 2007 |
| Spencer Offshore Limited | Mining & quarrying | 2018 |
| Spendeva Properties Ltd | Real estate | 2020 |
| Spendley Home Improvements Ltd | Construction | 2025 |
| SPM Lifting Services Limited | Manufacturing | 2019 |
| Srivam Limited | Manufacturing | 2016 |
| SRW Inspections Ltd | Professional & scientific | 2023 |
| SSR Legacy Limited | Wholesale & retail | 2025 |
| St@Ck'D Ltd | Hospitality | 2026 |
| Stafford House (Cleveleys) Ltd | Health & social care | 2003 |
| Stairway Media Ltd | Professional & scientific | 2018 |
| Star Bodies (North West) Ltd | Wholesale & retail | 2003 |
| Starmaker PAA Ltd | Arts & recreation | 2015 |
| Stedman Electrical Ltd | Construction | 2023 |
| Stevrail Limited | Construction | 2019 |
| STM Property Maintenance Ltd | Construction | 2024 |
| Stocksview Management Company Ltd | Households | 2023 |
| Stonebull Ltd | Transport & logistics | 2023 |
| Strawberry Bistro Ltd | Hospitality | 2016 |
| Strawberry Gardens Fleetwood Ltd | Hospitality | 2014 |
| Strength and Health Limited | Wholesale & retail | 2012 |
| Strickland Plastering Limited | Construction | 2025 |
| Stripe Social Ltd | Professional & scientific | 2018 |
| Studio 61 Advisers Limited | Arts & recreation | 2014 |
| Studio 61 Wealth Management Limited | Financial services | 2013 |
| Super Saver Fleetwood Market Ltd. | Wholesale & retail | 2013 |
| Super Saver Market Ltd | Wholesale & retail | 2021 |
| Supremevaletingfleetwood Ltd | Wholesale & retail | 2022 |
| Swift Steel Fabrications Ltd | Manufacturing | 2020 |
| T & F Property Group Ltd | Real estate | 2024 |
| T & H Civils Ltd | Construction | 2015 |
| T H L Construction Services Limited | Construction | 2015 |
| T&Gb Limited | Transport & logistics | 2025 |
| T5 Spares Ltd | Wholesale & retail | 2020 |
| Take Your Pick Fruit & VEG Ltd | Wholesale & retail | 2022 |
| Tarnbrook Park Residents Management Company Ltd | Households | 2022 |
| Tatemae Limited | Construction | 2019 |
| TC Marine Services Ltd | Professional & scientific | 2022 |
| TC Plasterers Limited | Construction | 2018 |
| TDC Media Limited | Information & communication | 2022 |
| Technical Services (North West) Ltd | Construction | 2017 |
| THE Bankers Table Ltd | Hospitality | 2026 |
| THE Chronic Edge Ltd | Professional & scientific | 2022 |
| THE Clothing Experts North West Ltd | Wholesale & retail | 2023 |
| THE Eating House Limited | Hospitality | 2008 |
| THE Evergreen Gift Store Ltd | Wholesale & retail | 2024 |
| THE Global Good Air Company Ltd | Real estate | 2021 |
| THE HIT Haunters Ltd | Wholesale & retail | 2026 |
| THE Holt-Jackson Book Company Limited | Extraterritorial | 2021 |
| THE JGM Group Ltd | Financial services | 2025 |
| THE Latham Group Limited | Financial services | 2016 |
| THE Mana Vault Ltd | Wholesale & retail | 2024 |
| THE Popmen Limited | Wholesale & retail | 2003 |
| THE Printing HUT Limited | Wholesale & retail | 2015 |
| THE Rabbit Patch Limited | Professional & scientific | 2010 |
| THE Rossall Foundation | Other services | 2005 |
| THE Scotch Bakery Fleetwood Limited | Manufacturing | 2025 |
| THE Steamer PUB Ltd | Hospitality | 2024 |
| THE Wainwright Club Ltd | Hospitality | 2012 |
| THE Yachtsman Limited | Health & social care | 2013 |
| Thomas Small Animal Practice Limited | Professional & scientific | 2013 |
| Thompsons Roofing Contractors Ltd | Construction | 2013 |
| Thorbrook Limited | Wholesale & retail | 1980 |
| Thorpe Construction & Project Management Ltd. | Extraterritorial | 2009 |
| Thryv Wellness Studio Limited | Health & social care | 2025 |
| Tidal Mechanical & Electrical Services Ltd | Construction | 2023 |
| Tiger Maintenance (North West) Limited | Administrative & support | 2010 |
| Timeless Consultation Ltd | Professional & scientific | 2019 |
| Tjmurraythemodel Ltd | Administrative & support | 2025 |
| TOM Didlock Ltd | Transport & logistics | 2015 |
| Tony Blundell Autos Ltd | Wholesale & retail | 2018 |
| Top Side & SUB Sea Solutions Ltd | Mining & quarrying | 2023 |
| Touchdown Residential Ltd | Real estate | 2020 |
| Towntrend Limited | Real estate | 1982 |
| TPH Installations Ltd | Construction | 2023 |
| Tram Shed Theatre Company Limited | Other services | 2005 |
| Tree Hero Limited | Agriculture & fishing | 2026 |
| Tsdbw Ltd | Wholesale & retail | 2017 |
| Turtle Fisheries Limited | Wholesale & retail | 2002 |
| Ukgm Limited | Other services | 2020 |
| Ukwarforged Ltd | Wholesale & retail | 2023 |
| Vajramind Ltd | Information & communication | 2025 |
| Valido Properties Limited | Real estate | 2019 |
| Vectura Logistics Ltd | Transport & logistics | 2025 |
| Veloce Wheels Limited | Manufacturing | 2018 |
| Vizan U.K. Limited | Other services | 2023 |