| Prelude Recruitment Limited | Administrative & support | 2019 |
| Premium Benefits Media Limited | Information & communication | 2021 |
| Premium Raws Partnership LLP | | 2025 |
| Priceless Supermarket Ltd | Wholesale & retail | 2017 |
| Pride in OUR Place C.I.C. | Administrative & support | 2024 |
| Primederm Ltd | Wholesale & retail | 2026 |
| Pro-Lock Support Ltd | Wholesale & retail | 2014 |
| Probuild (NW) Construction Limited | Construction | 2019 |
| Promuscle Products LLP | | 2023 |
| Promuscle Products Supplements Limited | Wholesale & retail | 2011 |
| Protocol Security Limited | Administrative & support | 2011 |
| Pulse Echo Inspection Ltd | Professional & scientific | 2024 |
| Pure Radiance Glow Clinic Limited | Other services | 2026 |
| Quantum Pixel Enterprises Ltd | Information & communication | 2024 |
| Quicksave Motorist Centre Holdings Ltd | Financial services | 2022 |
| R Garrett Electrical Ltd | Construction | 2018 |
| R&H Property Development NW Ltd | Real estate | 2026 |
| R&R Bedford Ltd | Transport & logistics | 2019 |
| R.G Bell Safety, Health and Environment Consultants Ltd | Professional & scientific | 2008 |
| R.Walker & Sons(Preston)Limited | Construction | 1925 |
| Radcliffe Developments Ltd | Construction | 2017 |
| Rapidesignit Limited | Information & communication | 2004 |
| Rare Advice Ltd | Professional & scientific | 2016 |
| Rbll Ltd | Professional & scientific | 2020 |
| RDW Engineering (LSA) Ltd | Manufacturing | 2013 |
| Reader Construction Ltd | Construction | 2021 |
| Recruiting and Consulting Ltd | Administrative & support | 2025 |
| Refurb (Wyre and Fylde) Ltd | Professional & scientific | 2002 |
| Reids Property Limited | Real estate | 2021 |
| Renergy (North West) Ltd | Water & waste | 2014 |
| Renewables & Cables Limited | Other services | 2020 |
| Respite Community Care Services Ltd | Real estate | 2013 |
| RGM Family Express Ltd | Wholesale & retail | 2025 |
| RH Property Management Limited | Households | 2020 |
| RIA Electrical Ltd | Construction | 2013 |
| Richardson's Fish House Limited | Hospitality | 2018 |
| Richardson's Fish HUT Limited | Hospitality | 2018 |
| Ridings Garage Limited | Wholesale & retail | 2025 |
| Rimmington Roofing Ltd | Construction | 2023 |
| Riversway Developments Ltd | Construction | 1999 |
| RLB Estates Ltd | Real estate | 2022 |
| Roamers Group Limited | Administrative & support | 2026 |
| Romeg UK Limited | Manufacturing | 2020 |
| Rope Access Electrical Services Limited | Manufacturing | 2015 |
| Rossall Enterprises Limited | Other services | 1986 |
| Rossall International Limited | Education | 2019 |
| RS Security Group Limited | Administrative & support | 2024 |
| RSJ Electrical Engineer & Consultancy Ltd | Professional & scientific | 2021 |
| Ruby Electricity Ltd | Energy | 2009 |
| Ruby Energy Holdings Ltd | Energy | 2016 |
| Ruby Finance Limited | Financial services | 2025 |
| Ruby GAS Ltd | Energy | 2002 |
| Russcaff Solutions Ltd | Construction | 2025 |
| Russian & Co Estates Ltd | Real estate | 2025 |
| Rutland Court (Poulton-Le-Fylde) Management Company Limited | Households | 2021 |
| RVH Property Management Limited | Real estate | 2019 |
| Rwuk Ltd | Administrative & support | 2021 |
| Rymann Holdings Limited | Real estate | 2018 |
| S & K Wrights Ltd | Construction | 2021 |
| S & P Transport Ltd | Transport & logistics | 2009 |
| S & R Emporium Ltd | Wholesale & retail | 2025 |
| S J Hull Electrical Contractors Ltd. | Construction | 2015 |
| S J N Technical Services Ltd | Construction | 2023 |
| S. G. Bowen Limited | Administrative & support | 2006 |
| S4L Limited | Wholesale & retail | 2008 |
| Salon Secret Fleetwood Ltd | Other services | 2023 |
| Sam's Garden Services Ltd | Agriculture & fishing | 2022 |
| Sam-Legal Limited | Professional & scientific | 2022 |
| Santias Group UK Ltd | Administrative & support | 2018 |
| Sarah Barclay Medical Negligence Law Limited | Professional & scientific | 2010 |
| Sarah Marie Coaching Ltd | Wholesale & retail | 2021 |
| Scaffolding North West Limited | Construction | 2025 |
| Scafftech Design (NW) Limited | Construction | 2018 |
| Scaffwright Limited | Construction | 2018 |
| Scenic Design Services Ltd | Professional & scientific | 2024 |
| Scfmnw Ltd | Households | 2026 |
| SCH Cafes Limited | Hospitality | 2026 |
| Scotforth Garage Limited | Real estate | 1968 |
| Scott James of Lytham Limited | Wholesale & retail | 2005 |
| Scott Offshore Marine Services Ltd | Professional & scientific | 2020 |
| Seaking Fisheries Limited | Wholesale & retail | 2004 |
| Sean Briggs Building and Joinery Limited | Construction | 2021 |
| Seaplant Exchange International Limited | Information & communication | 1983 |
| Second Chance Group Limited | Financial services | 2001 |
| Second Chance Limited | Wholesale & retail | 1989 |
| Secure Shutters and Doors Ltd | Construction | 2026 |
| SECURE24HRSTORAGE Ltd | Real estate | 2023 |
| Senthusaa & Co Ltd | Real estate | 2025 |
| Seven Oaks Country Park Ltd | Arts & recreation | 2020 |
| Shakespeare Monofilament UK Limited | Manufacturing | 1989 |
| Share in the Success Ltd | Wholesale & retail | 2011 |
| Sharp Data Projects Limited | Information & communication | 2015 |
| Sheraton Hotel (Blackpool) Limited | Hospitality | 2015 |
| Shireaz Ltd | Hospitality | 2024 |
| Shopper Avenue Ltd | Wholesale & retail | 2024 |
| Showman Signs Limited | Professional & scientific | 2010 |
| Shrelle's Ltd | Hospitality | 2025 |
| Shutty's Autos Ltd | Wholesale & retail | 2025 |
| Simon Bryning Legal Services Limited | Professional & scientific | 2023 |
| Sinerg Limited | Extraterritorial | 2016 |