| Saly Trading Ltd | Wholesale & retail | 2026 |
| SAM Morris ND Ltd | Health & social care | 2025 |
| Same Day Security Limited | Other services | 2019 |
| Samuel Wright Consulting Limited | Hospitality | 2023 |
| Sanda LH Ltd | Real estate | 2020 |
| Sandbourne House Ltd | Real estate | 2000 |
| Sanderson Aviation Solutions Limited | Administrative & support | 2025 |
| Sandringham Road Management Company Limited | Extraterritorial | 2010 |
| Sandscape Properties Limited | Real estate | 2024 |
| Sandy Cove Social Club (2016) Ltd | Hospitality | 2016 |
| Sandy Mclean Communications Limited | Professional & scientific | 2023 |
| Sango & Co Property Ltd | Real estate | 2019 |
| Sanihire Limited | Administrative & support | 2025 |
| Sansfords LLP | | 2023 |
| Santacasacare Ltd | Health & social care | 2026 |
| Sarah Redmond Consultancy Limited | Professional & scientific | 2024 |
| Sarah-Jane Lewis Ltd | Information & communication | 2024 |
| SAS Courier Solutions Ltd | Transport & logistics | 2025 |
| SAS Houses Limited | Real estate | 2019 |
| SAS1 Holdings Ltd | Real estate | 2025 |
| Sascha Thorpe Ltd | Construction | 2009 |
| Satriales Commerce Ltd | Administrative & support | 2024 |
| Saturnalia Trading Ltd | Wholesale & retail | 2019 |
| Sauchiehall Street Specsavers Limited | Wholesale & retail | 2011 |
| Sauflon CL Limited | Manufacturing | 2001 |
| Savannah Aerospace Limited | Manufacturing | 2025 |
| Save a Warrior UK CIC | Wholesale & retail | 2023 |
| Savio Limited | Information & communication | 2020 |
| Savoy Cottage Owners LLP | | 2009 |
| Savvy Protection Limited | Administrative & support | 2016 |
| SAW Developments Ltd | Construction | 2011 |
| SAW TEC (Southampton) Limited | Other services | 2002 |
| Sawasdee Thai Massage Ltd | Health & social care | 2018 |
| Sawn Holdings Limited | Financial services | 2024 |
| Saxon Recycling Limited | Extraterritorial | 2004 |
| SAY IT With Chips Limited | Hospitality | 2008 |
| SB Oktay Limited | Information & communication | 2008 |
| SB Safety Installations Ltd | Construction | 2022 |
| SBG Consulting Limited | Information & communication | 2012 |
| SBK Stubbington Limited | Real estate | 2006 |
| SBP Construction Ltd | Construction | 2019 |
| SBS21 K9 Protection Services Ltd | Administrative & support | 2021 |
| Sbvm Investments Limited | Real estate | 2015 |
| SC Aesthetics Ltd | Other services | 2020 |
| SC Causewayside Limited | Construction | 2016 |
| SC Claypath Limited | Construction | 2014 |
| SC Claypath Management Limited | Households | 2014 |
| SC Holdings (Southern) Ltd | Financial services | 2016 |
| SC Jewellery Ltd | Wholesale & retail | 2025 |
| SC Midco Limited | Construction | 2014 |
| SC Mitchams Corner Limited | Construction | 2013 |
| SC Mitchams Corner Management Limited | Real estate | 2013 |
| SC Osney Lane Limited | Construction | 2014 |
| SC Osney Lane Management Limited | Households | 2012 |
| SC Pelham Terrace Limited | Construction | 2016 |
| SC Pelham Terrace Management Limited | Real estate | 2013 |
| SC Pulteney Road Limited | Construction | 2014 |
| SC Pulteney Road Management Limited | Households | 2014 |
| SC Software Ltd | Administrative & support | 2017 |
| SC Walmgate Limited | Construction | 2012 |
| SC Walmgate Management Limited | Real estate | 2012 |
| SCA Dispute Resolution Ltd | Professional & scientific | 2023 |
| Scaffcom Limited | Financial services | 2025 |
| Scaffoldtech Group Limited | Administrative & support | 2025 |
| Scafmax Limited | Construction | 2024 |
| Scarborough Specsavers Hearcare Limited | Wholesale & retail | 2006 |
| Scarborough Visionplus Limited | Wholesale & retail | 1991 |
| Scarlett Retail Ltd | Wholesale & retail | 2023 |
| Scarter Holdings Limited | Manufacturing | 2018 |
| SCD Realisations Limited | Manufacturing | 2017 |
| Scene IT ALL Construction Ltd | Construction | 2021 |
| SCF 163CSP 1 GP Limited | Financial services | 2022 |
| SCF 163CSP 2 GP Limited | Financial services | 2022 |
| SCF 163CSP Nominee Limited | Financial services | 2022 |
| SCF Cambridge 1 GP Limited | Financial services | 2022 |
| SCF Cambridge 1 LP | | 2022 |
| SCF Cambridge 2 GP Limited | Financial services | 2022 |
| SCF Cambridge 2 LP | | 2022 |
| SCF Cambridge Nominee Limited | Financial services | 2022 |
| SCF Gracechurch 1 GP Limited | Financial services | 2022 |
| SCF Gracechurch 1 LP | | 2022 |
| SCF Gracechurch 2 GP Limited | Financial services | 2022 |
| SCF Gracechurch 2 LP | | 2022 |
| SCF Gracechurch Nominee Limited | Financial services | 2022 |
| SCF Healthcare Furniture Limited | Manufacturing | 2015 |
| Schaublin Machine Tools Limited | Wholesale & retail | 2007 |
| Schematiks Limited | Information & communication | 2019 |
| Schofield Groundworks Limited | Construction | 1997 |
| Schofield Plant Services Limited | Manufacturing | 2002 |
| School Britannia Ltd | Administrative & support | 2013 |
| Schroders Capital Private Equity UK V Limited | Financial services | 2025 |
| Schroders Capital Private Equity UK VI Limited | Financial services | 2025 |
| Schroders Capital Private Equity UK VII Limited | Financial services | 2026 |
| SCI Fire Protection Limited | Construction | 2017 |
| SCO Property & Investments Limited | Real estate | 2023 |
| Scomech Services Ltd | Construction | 2025 |
| Scorpio Energy Surveys Ltd | Professional & scientific | 2025 |
| Scotts Home Improvements Limited | Construction | 2001 |
| Scoutr Sports Ltd | Arts & recreation | 2023 |
| Scrap Car Comparison Limited | Wholesale & retail | 2013 |