| Rustington Retail Park Specsavers Limited | Wholesale & retail | 2018 |
| Rustington Specsavers Limited | Wholesale & retail | 2005 |
| Rustington Visionplus Limited | Wholesale & retail | 2005 |
| RVH Business Ltd | Professional & scientific | 2021 |
| RW Travel Limited | Extraterritorial | 2016 |
| RY Automobiles Limited | Other services | 2020 |
| Ryde Specsavers Hearcare Limited | Wholesale & retail | 2026 |
| Ryde Specsavers Limited | Wholesale & retail | 2004 |
| Ryde Visionplus Limited | Wholesale & retail | 2004 |
| RYE Marine Limited | Transport & logistics | 2026 |
| Rytec Dental Studio Limited | Health & social care | 2013 |
| Rytec Venture Limited | Real estate | 2021 |
| S & H Property Management Services Ltd | Households | 2019 |
| S & J Armstrong Limited | Extraterritorial | 1998 |
| S & J Cleaning Commercial Ltd | Other services | 2009 |
| S & R Property Consultancy Ltd | Real estate | 2019 |
| S a Morgan & Family Limited | Hospitality | 2020 |
| S and C Cars Ltd | Wholesale & retail | 2019 |
| S Conway Engineering Limited | Construction | 2003 |
| S Cross Limited | Arts & recreation | 2009 |
| S G Consulting International Ltd | Professional & scientific | 2025 |
| S J Siejko Ltd | Manufacturing | 2014 |
| S L Carpentry Limited | Construction | 2019 |
| S L Rental (Guildford) Limited | Real estate | 2020 |
| S L Rental Limited | Real estate | 2010 |
| S One Composites Limited | Other services | 2024 |
| S R Prop Master Limited | Arts & recreation | 2014 |
| S Steele Holdings Ltd | Financial services | 2024 |
| S T Engineering Consultants Limited | Professional & scientific | 2022 |
| S Training Ltd | Construction | 2025 |
| S W Technical Services Ltd | Professional & scientific | 2021 |
| S&I Group Ltd | Real estate | 2018 |
| S&L Southern Drylining Limited | Construction | 2020 |
| S&N Global Trading Limited | Financial services | 2025 |
| S&N IT Services Limited | Information & communication | 2013 |
| S&S Orawiec Transport Ltd | Transport & logistics | 2023 |
| S&T Healthcare Limited | Health & social care | 2014 |
| S&W Accountancy Services Limited | Professional & scientific | 2008 |
| S&W Motion Ltd | Information & communication | 2024 |
| S.&J. Builders (Southern)Limited | Construction | 1997 |
| S.J.W. Limited | Administrative & support | 1986 |
| S.M. Paines Financial Holdings Ltd | Financial services | 2023 |
| S.P.A.H. Limited | Construction | 2015 |
| S.W.Hull & SON (Farms) Limited | Agriculture & fishing | 1962 |
| S.W.Marchant Limited | Manufacturing | 1970 |
| S4 Personnel Limited | Administrative & support | 2006 |
| SA Energy Ltd | Professional & scientific | 2019 |
| SA Realty Ltd | Real estate | 2020 |
| SA Telecoms Limited | Information & communication | 2025 |
| Saab Seaeye Limited | Manufacturing | 1986 |
| Sabiba Ltd | Wholesale & retail | 2022 |
| Sackville Smeets Limited | Wholesale & retail | 2023 |
| Sadlers Building & Carpentry Ltd | Construction | 2010 |
| SAF Transport and Distribution Limited | Transport & logistics | 2022 |
| Safe Hands - the Safeguarding and Training Consultancy Limited | Professional & scientific | 2025 |
| Safe Hands Property Investments Ltd | Real estate | 2025 |
| Safe Obstetric Systems Limited | Manufacturing | 2006 |
| Safecell Security Ltd | Administrative & support | 2002 |
| Safeguard (N/W) Ltd | Construction | 1988 |
| Safeguard Construction Limited | Construction | 2016 |
| Safeinsound Ltd | Information & communication | 2026 |
| Safepoint 360 Consultancy Ltd | Construction | 2026 |
| Safesync Solutions Limited | Information & communication | 2025 |
| Safevue Alarms Limited | Administrative & support | 2021 |
| Safevue Cctv Ltd | Administrative & support | 2020 |
| Safevue Security Limited | Administrative & support | 2021 |
| Saffron Walden Specsavers Hearcare Limited | Wholesale & retail | 2024 |
| Saffron Walden Specsavers Limited | Wholesale & retail | 2009 |
| Saffron Walden Visionplus Limited | Wholesale & retail | 2009 |
| Safran Helicopter Engines UK Limited | Manufacturing | 1973 |
| Saibike Rush Limited | Wholesale & retail | 2025 |
| Sailing Logic Events Limited | Arts & recreation | 2012 |
| Sailing Logic Limited | Administrative & support | 2017 |
| Sailing Logic Powerboat School Limited | Education | 2016 |
| Sailing Logic Sailing School Limited | Education | 2016 |
| Sailing Logic Shorebased School Limited | Education | 2016 |
| Sailing Therapy Community Interest Company | Arts & recreation | 2008 |
| Saint Target Co 1 Limited | Financial services | 2024 |
| Sairees Ltd | Wholesale & retail | 2022 |
| Sakura Care Ltd | Health & social care | 2018 |
| Sale Specsavers Hearcare Limited | Wholesale & retail | 2016 |
| Sale Specsavers Limited | Wholesale & retail | 1992 |
| Sale Visionplus Limited | Wholesale & retail | 1992 |
| Salford Specsavers Limited | Wholesale & retail | 1997 |
| Saling 2012 Ltd | Professional & scientific | 2012 |
| Salisbury Specsavers Hearcare Limited | Wholesale & retail | 2006 |
| Sally Wags Dog Walking Ltd | Other services | 2025 |
| Saltamonte Consulting Limited | Administrative & support | 2018 |
| Saltash Specsavers Hearcare Limited | Wholesale & retail | 2026 |
| Saltash Specsavers Limited | Wholesale & retail | 2010 |
| Saltcoats Specsavers Limited | Wholesale & retail | 2002 |
| Saltire Strategy Ltd | Information & communication | 2026 |
| Saltus Corporate Limited | Administrative & support | 2021 |
| Saltus Financial Planning Limited | Financial services | 2015 |
| Saltus Financial Services Limited | Financial services | 1997 |
| Saltus Partners (Ukco) Limited | Financial services | 2004 |
| Saltus Partners LLP | | 2004 |
| Saltus Partnership Limited | Professional & scientific | 2011 |
| Saltus Wealth Partnership Limited | Financial services | 2006 |
| Saltwind Holdings Limited | Construction | 2023 |