| Secure Mortgages and Protection Ltd | Financial services | 2019 |
| Securestay Management Ltd | Hospitality | 2026 |
| Seedgap Ltd | Professional & scientific | 2013 |
| Sefa GAS Services Ltd | Construction | 2022 |
| Sentinel Predictive Systems Ltd | Professional & scientific | 2025 |
| Sentinel Security Management Ltd | Administrative & support | 2026 |
| Serafini Distribution Falkirk Limited | Transport & logistics | 2024 |
| Serenity by AMY Limited | Other services | 2025 |
| Setag Consulting Ltd | Information & communication | 2021 |
| Setchfield Technical Services Ltd | Information & communication | 2015 |
| Seven Stars Accountants Ltd | Financial services | 2018 |
| Sevenstars IT Ltd | Wholesale & retail | 2020 |
| Seventyseven Consultancy Ltd | Wholesale & retail | 2025 |
| SF Media Ltd | Administrative & support | 2023 |
| Sfergusons Ltd | Professional & scientific | 1997 |
| SG Formulations Ltd | Other services | 2019 |
| SG Quality & Electrical Consultants Ltd | Construction | 2023 |
| Sgbs Projects Ltd | Construction | 2026 |
| SGH Contracts (Bathgate) Limited | Construction | 2023 |
| SGK Consulting Ltd | Professional & scientific | 2025 |
| SH Ecom Ltd | Wholesale & retail | 2026 |
| Shaks Goods Limited | Wholesale & retail | 2019 |
| Shangri-La Capital Ltd | Hospitality | 2025 |
| Sharkdog Ltd | Administrative & support | 2014 |
| Sharon Mwale Limited | Professional & scientific | 2013 |
| Sharps Trading Limited | Wholesale & retail | 2011 |
| Sheltered Housing Management Limited | Administrative & support | 1981 |
| Shieldhill Keystore Ltd | Wholesale & retail | 2018 |
| Shieldhill Youth/Community Hall Project | Arts & recreation | 2009 |
| Shiftandlift Ltd | Transport & logistics | 2025 |
| Shine & Build Ltd | Construction | 2026 |
| Shiny Hands Falkirk Ltd | Other services | 2024 |
| Shop Yard Limited | Wholesale & retail | 2026 |
| Shore Auto Salvage Ltd. | Other services | 2016 |
| Showtime Cleaning Services Ltd | Administrative & support | 2025 |
| SHU Falkirk Limited | Hospitality | 2021 |
| Sibani Enterprises Limited | Hospitality | 2023 |
| Sibf Ltd | Education | 2023 |
| Sicilian Bakery Limited | Manufacturing | 2022 |
| Sicilian Hospitality Limited | Hospitality | 2026 |
| Sidewood Canine Services Ltd | Arts & recreation | 2025 |
| Sight & Sound PA & Lighting Ltd | Arts & recreation | 2007 |
| Sigma Sciences Limited | Information & communication | 2013 |
| Sigmaco LLP | | 2024 |
| Sign@Events Ltd | Professional & scientific | 2025 |
| Signet Group (Scotland) Limited | Construction | 2026 |
| Signet Group Holdings Limited | Financial services | 2026 |
| Sikorska Group Ltd | Manufacturing | 2024 |
| Silent Star Limited | Hospitality | 2023 |
| Silevon Limited | Wholesale & retail | 2011 |
| Silver Acanthus Limited | Real estate | 2022 |
| Silvermill Properties Limited | Real estate | 2014 |
| SIM Contracts Ltd | Construction | 2021 |
| Sinx Bathrooms Ltd | Construction | 2021 |
| Sisc Ltd | Transport & logistics | 2026 |
| Site Group Holdings Limited | Construction | 2022 |
| Site Roofing Limited | Construction | 2022 |
| SIX Murray Park Limited | Hospitality | 2025 |
| SJA Cyber Limited | Information & communication | 2026 |
| SJK9 Supplies Ltd | Manufacturing | 2025 |
| SK26 Sports Limited | Arts & recreation | 2023 |
| SKF Investments Ltd | Real estate | 2025 |
| Skidz Limited | Wholesale & retail | 1998 |
| Skin Geek Group Ltd | Other services | 2017 |
| Skin Geek Holdings Ltd | Financial services | 2024 |
| Skinners Construction Limited | Construction | 2021 |
| Skinners Property Limited | Construction | 2024 |
| Sky Guard Roofing & Slating Ltd | Construction | 2025 |
| Skye Property Holdings Limited | Real estate | 2021 |
| Skyemore R.V.'s Limited | Information & communication | 2007 |
| Skyforce Avionics Ltd | Public administration | 2025 |
| Skyline Shawarma Ltd | Hospitality | 2024 |
| Slopemeister Brewing Company Limited | Manufacturing | 2018 |
| Slothlife Solution Limited | Transport & logistics | 2019 |
| SM Fitness & Nutrition Limited | Other services | 2021 |
| Small Business Accountancy Scotland Limited | Professional & scientific | 2015 |
| Smart Cookie Ltd | Information & communication | 2026 |
| Smart Tech Autobody Ltd | Manufacturing | 2010 |
| SMB Property Limited | Real estate | 2015 |
| SMH Media Scotland Limited | Professional & scientific | 2024 |
| SMI (Scotland) Limited | Wholesale & retail | 2015 |
| Smith Leiper Construction Ltd | Manufacturing | 2017 |
| Smokin' Crows Music Limited | Information & communication | 2022 |
| SMS Commerce & Enterprise Limited | Wholesale & retail | 2024 |
| Snackfinder Ltd | Information & communication | 2026 |
| SND Safety Solutions Ltd | Professional & scientific | 2018 |
| Sneddon Joiners & Builders Ltd | Construction | 2019 |
| Snoodstore Ltd | Manufacturing | 2017 |
| Social Inns Limited | Hospitality | 2023 |
| Social Rich Limited | Professional & scientific | 2025 |
| Socialsaurus Limited | Other services | 2020 |
| Solar Centre Scotland Ltd | Wholesale & retail | 2023 |
| Solas Healthcare (Consulting) Ltd. | Other services | 2024 |
| Solas Healthcare (Scotland) Ltd. | Manufacturing | 2023 |
| Solifer Ltd | Wholesale & retail | 2023 |
| Solutions in Mind Coaching & Training Ltd | Education | 2017 |
| Solvinus Limited | Professional & scientific | 2009 |
| Sonell Business Intelligence Solutions Limited | Professional & scientific | 2022 |
| Sophie Gets Social Ltd | Professional & scientific | 2021 |
| Sorella Hair Limited | Other services | 2018 |