| DC Pipeline Ltd | Construction | 2019 |
| DCR Tipscar Ltd | Transport & logistics | 2016 |
| DCV Investments Ltd | Real estate | 2023 |
| DE Saram Associates Limited | Real estate | 1983 |
| Dealer DOC COM Ltd | Information & communication | 2021 |
| Debrief CIC | Education | 2026 |
| Dees Vintage Finds Limited | Wholesale & retail | 2025 |
| Delenty International Ltd. | Transport & logistics | 2010 |
| Delux Installations Ltd | Construction | 2018 |
| Dental Key Software Ltd | Information & communication | 2026 |
| Dental Supply and Engineering Limited | Construction | 1998 |
| Design Castle (SW) Ltd | Real estate | 2019 |
| Designs by in EX Limited | Professional & scientific | 2014 |
| Desire Jewels Ltd | Wholesale & retail | 2015 |
| Devon & Cornwall Aesthetics Academy Ltd | Health & social care | 2019 |
| Devon Air Conditioning Limited | Construction | 2025 |
| Devon Built Ltd | Manufacturing | 2023 |
| Devon Caters Ltd | Hospitality | 2025 |
| Devon Clocks Limited | Manufacturing | 1983 |
| Devon Fields Consulting Ltd | Professional & scientific | 2018 |
| Devon Getaways Ltd | Hospitality | 2021 |
| Devon Heating Services Limited | Construction | 2014 |
| Devon Lodges Ltd | Hospitality | 2011 |
| Devon Quality Fish Holdings Limited | Agriculture & fishing | 2020 |
| Devon Quality Fish Limited | Agriculture & fishing | 2011 |
| Devon Signs Ltd | Manufacturing | 2019 |
| Devon Stone Limited | Administrative & support | 2004 |
| Devon Wallcare Limited | Administrative & support | 2009 |
| Devon Wealth Management Ltd | Professional & scientific | 2021 |
| Devoncourt Hotels Limited | Hospitality | 1965 |
| Devonecoheat Ltd | Construction | 2022 |
| Devonia Management Company Sidmouth Limited | Households | 1990 |
| DG Martin Ltd | Wholesale & retail | 2024 |
| DGB (South West) Limited | Construction | 2016 |
| Dgitrack Ltd | Administrative & support | 2019 |
| Diadin Limited | Construction | 1977 |
| Dial South West Limited | Other services | 2003 |
| Diamond Hand Car Wash Ltd | Administrative & support | 2019 |
| Diamond Home Support South Hams Ltd | Administrative & support | 2015 |
| Diesel Properties Limited | Real estate | 2019 |
| DIGITALPRODUCTS4U Ltd. | Wholesale & retail | 2025 |
| Dinan Way Laundry Limited | Administrative & support | 2023 |
| Dinan Way Laundry Services Limited | Administrative & support | 2020 |
| Discover Nutrition Limited | Health & social care | 2026 |
| Discover Your Doorstep Community Interest Company | Education | 2024 |
| DJB Systems UK Limited | Transport & logistics | 2014 |
| DJK Properties Limited | Real estate | 2012 |
| DK PUB Solutions Ltd | Hospitality | 2024 |
| Dkfarley Limited | Hospitality | 2024 |
| Dolforgan Court Management (Exmouth) Limited | Households | 1987 |
| DOWNFALL303 Ltd | Hospitality | 2025 |
| DR S Fisher Ltd | Education | 2024 |
| Drakes Gardens Management Company Limited | Households | 1986 |
| DRG Crash Repairs Ltd | Wholesale & retail | 2025 |
| Driftwood Home Improvements Ltd | Construction | 2024 |
| Driftwood Property Ltd | Real estate | 2021 |
| Drinks Rentals Ltd | Real estate | 2025 |
| Drywall Finishings Limited | Construction | 2015 |
| DTE PM Ltd | Real estate | 2018 |
| Dunborne Limited | Health & social care | 2021 |
| DW Fisheries Group Limited | Agriculture & fishing | 2024 |
| DW Fisheries Limited | Agriculture & fishing | 2014 |
| Dwenger Roofing Ltd | Construction | 2012 |
| E G Creations Limited | Information & communication | 2018 |
| Eagle Investments (Exmouth) Limited | Construction | 2020 |
| Eagle Investments (SW) Limited | Construction | 2020 |
| Eagle Investments Limited | Construction | 1955 |
| Eagle Investments Southwest Limited | Construction | 2020 |
| Eaglesite Limited | Information & communication | 2009 |
| Earp Enterprises Limited | Wholesale & retail | 2021 |
| East Devon Boiler Services Ltd | Construction | 2025 |
| East Devon Casualty Service Limited | Administrative & support | 2010 |
| East Devon Citizens Advice Bureau | Information & communication | 2006 |
| East Devon Tree Care Limited | Agriculture & fishing | 2007 |
| East of EXE Construction Ltd | Construction | 2018 |
| Easy Green Properties Limited | Real estate | 2025 |
| Easytalk Ltd | Education | 2026 |
| Eaton-Terry Clark Holidays Ltd | Real estate | 2008 |
| Ebby's Inns Limited | Hospitality | 2017 |
| Eco Pro Renewables Limited | Energy | 2016 |
| Ecow Ltd | Professional & scientific | 2024 |
| Eden Court Salterton Road Management Company Limited | Real estate | 2008 |
| Edge Watersports Limited | Wholesale & retail | 2006 |
| Edrs Paintwork Limited | Wholesale & retail | 2021 |
| Edumentis Ltd | Education | 2025 |
| Edward Butler Ltd | Real estate | 2011 |
| Elecworx Devon Ltd | Construction | 2021 |
| Elevation Space Limited | Administrative & support | 2013 |
| Elite Markings Ltd | Construction | 2022 |
| Elite Potential Ltd | Education | 2022 |
| Elite Tile (South West) Limited | Construction | 2024 |
| Elwyn Green Management Company Limited | Households | 2018 |
| Elwyn Road Management Company Limited | Households | 2010 |
| Emedia International Limited | Manufacturing | 2019 |
| Emily J Ltd | Real estate | 2022 |
| Eminence Care Limited | Health & social care | 2003 |
| EN Academy Ltd | Health & social care | 2016 |
| Energy Roofing (South West ) Ltd | Construction | 2025 |
| Engineering Web Services Ltd | Information & communication | 2019 |
| Ensign Motorsports Limited | Arts & recreation | 2024 |