| S&P Building & Construction (Devon) Limited | Construction | 2020 |
| S. D. Richards (Building) Limited | Construction | 2014 |
| SA Freeman Limited | Administrative & support | 2024 |
| Safety Direct Worldwide Group Ltd | Construction | 2021 |
| Safety Task Ltd | Professional & scientific | 2025 |
| Safexe Ltd | Construction | 2025 |
| Salaar K Enterprises Limited | Wholesale & retail | 2025 |
| Salamander Digital Ltd | Professional & scientific | 2024 |
| Salter Partnership (SW) Ltd | Real estate | 2023 |
| Salter Property Investments Limited | Construction | 2013 |
| Saltexmouth Ltd | Hospitality | 2026 |
| Salty Sea Limited | Health & social care | 2025 |
| SAM Management Company (Exmouth) Limited | Administrative & support | 2011 |
| Samantha's Leisure Ltd | Hospitality | 2013 |
| Sandbag Media Ltd | Information & communication | 2018 |
| Sandmoor Press Ltd | Information & communication | 2016 |
| Sandrevin Court Management Company Limited | Households | 2002 |
| Sandy Bay Holiday Park (Devon) Limited | Real estate | 1951 |
| Sandy Bay Holiday Park Holdings Limited | Financial services | 2017 |
| Sapphire Cleaning Exmouth Limited | Other services | 2017 |
| Sapphire Holiday Lets Ltd | Administrative & support | 2023 |
| Sapphire Housekeeping Ltd | Administrative & support | 2023 |
| Sapphire Stays SW Ltd | Hospitality | 2023 |
| Sarlsdown House Management Limited | Real estate | 2020 |
| SB Painters and Decorators Limited | Construction | 2017 |
| SB Property Group Holdings Limited | Financial services | 2022 |
| SC Southwest Limited | Financial services | 2006 |
| Scanpoint Ltd | Professional & scientific | 2025 |
| Scarlet Gifts Ltd | Wholesale & retail | 2018 |
| SCL COX Developments Ltd | Construction | 2013 |
| Scope Homes Ltd | Construction | 2021 |
| SDM Plumbing & Bathrooms Ltd | Construction | 2013 |
| Sea Dog Art Gallery Ltd | Wholesale & retail | 2022 |
| Sea Reach Consulting Limited | Professional & scientific | 2025 |
| Seacoat Property Enterprises Limited | Real estate | 2004 |
| Seafuser Ltd | Manufacturing | 2024 |
| Seaglass Gallery Ltd | Wholesale & retail | 2020 |
| Seashore Kiosk Ltd | Wholesale & retail | 2016 |
| Seaton Quay Management Limited | Real estate | 2025 |
| Secure Nest Property Ltd | Real estate | 2024 |
| Seeds 2 Totnes Ltd | Real estate | 2016 |
| Seller Spark Ltd | Wholesale & retail | 2024 |
| SENDME2WORK Ltd | Education | 2022 |
| Sensation Ltd | Wholesale & retail | 2025 |
| Serendipity (Devon) Ltd | Health & social care | 2009 |
| Settle UK CIC | Information & communication | 2024 |
| Seventh Sibling Ltd | Professional & scientific | 2025 |
| SFR Educatering Limited | Financial services | 2025 |
| Shaw & Shaw Properties Limited | Wholesale & retail | 2016 |
| Sheds Direct Devon Holdings Limited | Financial services | 2025 |
| Sheds Direct Devon Limited | Manufacturing | 2007 |
| Shield Maidens of Medusa UA Limited | Health & social care | 2026 |
| Shift Enterprises Limited | Arts & recreation | 2020 |
| Shift-It (Waste) Limited | Water & waste | 2017 |
| Shine Jones Property Ltd | Real estate | 2026 |
| Shopmonkeypro Ltd | Manufacturing | 2020 |
| Shrewsbury Avenue (London) Limited | Administrative & support | 2015 |
| Sidford Developments (SW) Ltd | Real estate | 2023 |
| Silva Cycles Ltd | Manufacturing | 2016 |
| Silver and Gold Exchange Limited | Wholesale & retail | 2023 |
| Simon Santucci Decorators Ltd | Construction | 2016 |
| Simon Tate Plumbing and Heating Limited | Construction | 2012 |
| Singleton & Manning Limited | Administrative & support | 2007 |
| Singleton Builders Limited | Construction | 2014 |
| Sisi & Brooke Limited | Wholesale & retail | 2018 |
| Sissons Design and Build Ltd | Construction | 2023 |
| SIX Degrees Solutions Ltd | Professional & scientific | 2014 |
| SJ Consultancy SW Ltd | Administrative & support | 2018 |
| SLG Land Ltd | Real estate | 2020 |
| Small Steps Big Vision Ltd | Education | 2021 |
| Smarstay Ltd | Hospitality | 2022 |
| Smith Maxwell Enterprises Limited | Real estate | 2023 |
| Smokinaces Limited | Manufacturing | 2024 |
| Snape & Vanaelst Limited | Real estate | 2025 |
| Snowballs Consultancy Limited | Professional & scientific | 2022 |
| SO Close Limited | Professional & scientific | 2020 |
| Social Enterprise Academy Limited | Education | 2006 |
| Sofia&David Cleaning Service Ltd | Administrative & support | 2023 |
| Soft-Works Technologies Limited | Information & communication | 2006 |
| Solpardus Limited | Wholesale & retail | 2022 |
| South West Alternative Provision Ltd | Education | 2023 |
| South West Hampers Limited | Wholesale & retail | 2015 |
| South West Property Trading Limited | Construction | 2003 |
| South West Trailers Ltd | Wholesale & retail | 2021 |
| Southern Breeze E111 Limited | Agriculture & fishing | 2026 |
| Southern Spirit E333 Limited | Agriculture & fishing | 2026 |
| Southon & Co Accountants Limited | Professional & scientific | 2016 |
| Southwest Properties (Exmouth) Limited | Real estate | 2012 |
| Southwest Properties Holdings Limited | Financial services | 2021 |
| Southwestpropgroupcf Limited | Real estate | 2023 |
| Sovereign Accountancy Limited | Professional & scientific | 2012 |
| Space Architects UK Limited | Professional & scientific | 2009 |
| Specialist Publishers Ltd | Health & social care | 2008 |
| Speq Recruitment Ltd | Administrative & support | 2022 |
| Spinback Events Limited | Manufacturing | 2019 |
| Spindrift Amenities Ltd | Households | 2021 |
| Spiro Solutions Ltd | Administrative & support | 2026 |
| SPL Consulting Ltd | Professional & scientific | 2024 |
| Splash Projects Limited | Administrative & support | 2000 |
| SPS Marketing Limited | Professional & scientific | 2018 |