| DR Seville Ltd | Health & social care | 2025 |
| DR Seville Property Holdings Ltd | Real estate | 2026 |
| DR2TH Ltd | Health & social care | 2024 |
| DR83 Limited | Information & communication | 2018 |
| Drakes Broughton Pershore Management Company Limited | Households | 2019 |
| Dream Routes Ltd | Administrative & support | 2025 |
| Dreamhouse Productions Limited | Information & communication | 2023 |
| Dreamscape Realty Ltd | Real estate | 2024 |
| Drfp Ltd | Health & social care | 2025 |
| Driving Monitor Limited | Professional & scientific | 2010 |
| DSR Oral Healthcare Ltd | Health & social care | 2020 |
| DSR Ventures Ltd | Real estate | 2019 |
| Dtm(Nw) Limited | Wholesale & retail | 2021 |
| Dubai Shawarma Limited | Hospitality | 2024 |
| Dudley Road Developments Ltd | Real estate | 2018 |
| DUN BRI Plant UK Ltd | Transport & logistics | 2023 |
| Durose Pipework Engineering Limited | Construction | 2002 |
| DV8 Recruitment Professionals Ltd | Administrative & support | 2017 |
| DWD MON Electrical Limited | Energy | 2025 |
| Dwell & Dwell Ltd | Real estate | 2021 |
| Dynasty Trading Investments Ltd | Administrative & support | 2024 |
| E and Z Kensington Limited | Real estate | 2024 |
| E H Williams (Liverpool) Holdings Limited | Professional & scientific | 1953 |
| E H Williams Garden Centres and Nurseries Limited | Wholesale & retail | 1967 |
| E Implant Services Limited | Health & social care | 2017 |
| E P Garage Group Limited | Wholesale & retail | 2024 |
| E'Lan Hair & Beauty Ltd | Other services | 2019 |
| E-Fynity Ltd | Wholesale & retail | 2022 |
| E.J.O Aviation Ltd | Manufacturing | 2026 |
| E2E Education Limited | Education | 2018 |
| E2E Integration Limited | Information & communication | 2011 |
| E2E Technologies Limited | Information & communication | 2012 |
| EA Carr Holdings Limited | Professional & scientific | 2025 |
| EA Thomas Property Ltd | Real estate | 2025 |
| Eagle Housing Solutions Ltd | Real estate | 2022 |
| Eagle Medical Limited | Health & social care | 2017 |
| Easifit Tyre Collections Ltd | Transport & logistics | 2024 |
| Easifit Tyres and Service Centre Ltd | Wholesale & retail | 2017 |
| Eastern Delight Joy Ltd | Hospitality | 2026 |
| Eastgate DP Limited | Health & social care | 2023 |
| Eaton Electrical Services Ltd | Construction | 2026 |
| EB Eyecare Limited | Wholesale & retail | 2023 |
| Ecesis Habitat Evolution Ltd | Wholesale & retail | 2012 |
| Eco Connexions Limited | Professional & scientific | 2020 |
| Eco Truck Clean Ltd | Wholesale & retail | 2014 |
| Ecogreen Plant Hire Ltd | Administrative & support | 2013 |
| Econation Recycling (UK) Limited | Manufacturing | 2023 |
| Ecorrugated Limited | Manufacturing | 2011 |
| Ecosystems Retail Limited | Information & communication | 2014 |
| ED & MA Property Ltd | Real estate | 2024 |
| Edmirage Studios Ltd | Information & communication | 2026 |
| Edsential Community Interest Company | Hospitality | 2015 |
| Edtech Impact Limited | Information & communication | 2018 |
| Education Work Employment (EWE) Ltd | Professional & scientific | 2022 |
| Edwards Dent Ltd | Health & social care | 2025 |
| EET H2 Power Limited | Energy | 2024 |
| EET Hydrogen (HPP1 Holdings) Limited | Financial services | 2024 |
| EET Hydrogen (HPP1 JV) Limited | Financial services | 2024 |
| EET Hydrogen (HPP1) Limited | Manufacturing | 2024 |
| EET Hydrogen Holdings Limited | Financial services | 2025 |
| EET Hydrogen Limited | Financial services | 2021 |
| EET Hydrogen Power Limited | Energy | 2024 |
| EET Operations Limited | Administrative & support | 2025 |
| EET Property Holdings Limited | Real estate | 2024 |
| EET Property Limited | Real estate | 2024 |
| EET Property Services Limited | Real estate | 2024 |
| Effatha Foods Limited | Wholesale & retail | 2024 |
| Egby Trans Limited | Transport & logistics | 2018 |
| Eggy Records Limited | Information & communication | 2017 |
| EIC LAB Limited | Professional & scientific | 2014 |
| Eigendyne Limited | Professional & scientific | 2021 |
| Eikia Property Limited | Real estate | 2023 |
| El-Ray Ltd | Manufacturing | 2023 |
| Electrical OIL Services Limited | Manufacturing | 1999 |
| Electricity Solutions Ltd | Construction | 2006 |
| Elegance Plumbing Heating and Bathrooms Limited | Construction | 2020 |
| Elevate Admin Limited | Administrative & support | 2025 |
| Elevate Benefits Limited | Administrative & support | 2025 |
| Elevate Engagement Limited | Administrative & support | 2025 |
| Eleven North East Ltd | Financial services | 2018 |
| ELEVEN06 Photography Limited | Other services | 2017 |
| Elite Grinding Services Limited | Manufacturing | 2003 |
| Elite Property Renovations Limited | Real estate | 2016 |
| Elixir Property Ltd | Real estate | 2024 |
| Ellab (UK) Limited | Wholesale & retail | 1985 |
| Ellab Monitoring Solutions Ltd | Manufacturing | 2007 |
| Ellbontay NDT Ltd | Professional & scientific | 2019 |
| Ellesmere Driver Supplies Ltd | Transport & logistics | 2022 |
| Ellesmere Fabrications Ltd | Manufacturing | 2021 |
| Ellesmere Nail Ltd | Other services | 2023 |
| Ellesmere Port & Neston Community Transport Ltd | Transport & logistics | 2007 |
| Ellesmere Port Catering Ltd | Hospitality | 2025 |
| Ellesmere Port Club of Gymnastics C.I.C. | Arts & recreation | 2013 |
| Ellesmere Port Collective CIC | Arts & recreation | 2025 |
| Ellesmere Port Engine Centre E.P Ltd | Wholesale & retail | 2025 |
| Ellesmere Port Engine Centre Limited | Wholesale & retail | 2008 |
| Ellesmere Port Insulation Company Limited | Wholesale & retail | 1975 |
| Ellesmere Port Lifting Gear Limited | Manufacturing | 2008 |
| Ellesmere Port Ltd | Administrative & support | 2019 |
| Ellesmere Port Services Limited | Wholesale & retail | 2015 |