| Seamanship International Limited | Information & communication | 1998 |
| Seamar Investments LP | | 2014 |
| Seamaster Marine L.P. | | 2012 |
| Seamless Hospitality Technology Limited | Information & communication | 2023 |
| Seamoss Visuals Ltd | Information & communication | 2024 |
| Seamotion Ltd | Arts & recreation | 2006 |
| Sean Minto Electrics Limited | Construction | 2016 |
| Sean Nicol Investments Ltd | Real estate | 2018 |
| Sean Wood Vintage and Collectables Ltd | Professional & scientific | 2024 |
| Seapoint Property Group Limited | Construction | 2025 |
| Searates LP | | 2013 |
| Search Motive Ltd | Information & communication | 2012 |
| Seasalt Digital Limited | Information & communication | 2018 |
| Seascope Environmental Limited | Other services | 2012 |
| Seashell Homes Ltd | Real estate | 2025 |
| Seaside Bites Limited | Wholesale & retail | 2023 |
| Seaside Cross SP | | 2002 |
| Seaside Retail Ltd | Wholesale & retail | 2025 |
| Seaside Ventures LP | | 2013 |
| Seastar Tidal Ltd | Professional & scientific | 2023 |
| Seatech Consulting UK Limited | Administrative & support | 2013 |
| Seated Toad Limited | Health & social care | 2014 |
| Seaton Services LP | | 2015 |
| Seaton Solutions LP | | 2016 |
| Seatwell Import LP | | 2014 |
| Seavacation Ltd. | Real estate | 2009 |
| Seavation Ltd. | Extraterritorial | 2009 |
| Seaview Cottage Limited | Real estate | 2025 |
| Seaway SPB LP | | 2015 |
| Seaweed Pictures Ltd | Information & communication | 2023 |
| Seawest L.P. | | 2013 |
| SEB Shipping Service Ltd | Transport & logistics | 2014 |
| Seba 49 Ltd | Professional & scientific | 2024 |
| Seba Investments Ltd | Real estate | 2024 |
| Sebastian White Ltd | Professional & scientific | 2024 |
| Sebaulam Private Hire Ltd | Transport & logistics | 2015 |
| Sebino Group United LP | | 2019 |
| Sebrano Trade LP | | 2018 |
| Seb’S Urban Jungle Ltd | Wholesale & retail | 2021 |
| Secellus Safety Solutions Ltd | Professional & scientific | 2026 |
| Second Best Brewing Company Limited | Manufacturing | 2026 |
| Second Bounce Bite Limited | Real estate | 2019 |
| Second Look Ltd | Professional & scientific | 2019 |
| Second Order Works Ltd | Professional & scientific | 2026 |
| Second Shank Redemption Ltd | Wholesale & retail | 2025 |
| Second Stories Ltd | Wholesale & retail | 2023 |
| Second Stories Trading Ltd | Wholesale & retail | 2026 |
| Second Wave Growth Ltd | Professional & scientific | 2025 |
| Secondperspective Ltd. | Health & social care | 2017 |
| Seconds OUT Fight Store Ltd | Wholesale & retail | 2021 |
| Secondstage Property Ltd | Real estate | 2022 |
| Secquote LP | | 2016 |
| Secret Garden Distillery Limited | Manufacturing | 2014 |
| Secret Gardens Design Ltd | Administrative & support | 2021 |
| Secret Holding LP | | 2016 |
| Secret Pictures Ltd | Information & communication | 2023 |
| Secret Solstice Games Ltd | Arts & recreation | 2023 |
| Secretar Securities Limited | Other services | 1979 |
| Sectoa Limited | Hospitality | 2006 |
| Sector Geoscience Limited | Information & communication | 2021 |
| Secure Air Parks (Edinburgh) Limited | Transport & logistics | 1989 |
| Secure Hive Ltd | Information & communication | 2024 |
| Secure Logistics Ltd | Transport & logistics | 2025 |
| Securenet Innovations Ltd | Other services | 2024 |
| Securicorps - Security Management Ltd | Administrative & support | 2013 |
| Securite Invest LP | | 2011 |
| Security and Storage Ltd | Transport & logistics | 2025 |
| Security Engineering Service LP | | 2014 |
| Security Toolkit Limited | Extraterritorial | 2001 |
| Securox Consulting Ltd | Information & communication | 2026 |
| Secuthreat Ltd | Information & communication | 2020 |
| Secuvista Ltd | Real estate | 2025 |
| Sedan Projects LP | | 2016 |
| SEE Subsea Ltd | Information & communication | 2013 |
| Seebaldt International LP | | 2025 |
| Seebyte Holdings Limited | Financial services | 2013 |
| Seebyte Limited | Information & communication | 1999 |
| Seed Financial Planning Limited | Financial services | 2019 |
| Seed Marketing Solutions Ltd | Professional & scientific | 2019 |
| Seed Studio Scotland Limited | Other services | 2021 |
| Seedboost Ltd | Information & communication | 2017 |
| Seedcamp Founder L.P. | | 2014 |
| Seedcamp GP LLP | | 2014 |
| Seedcamp IV Founder LP | | 2017 |
| Seedcamp V (Scot) Limited | Financial services | 2020 |
| Seedcamp V Founder LP | | 2020 |
| Seedcamp VI (Scot) Limited | Financial services | 2022 |
| Seedcamp VI Founder LP | | 2022 |
| Seeded Private Equity Ltd | Professional & scientific | 2025 |
| Seedling Translations LP | | 2023 |
| Seedot Limited | Information & communication | 2025 |
| Seefin International & Co | | 1994 |
| Seeit Studio Limited | Wholesale & retail | 2026 |
| Seeking CR8TIVES Limited | Manufacturing | 2025 |
| Seelyon Limited | Information & communication | 2023 |
| Seemart Ltd | Real estate | 2024 |
| Seers Properties Limited | Real estate | 2024 |
| SEG Advisory Limited | Professional & scientific | 2024 |
| Segatech Consult LP | | 2017 |
| Segesta Impex LP | | 2015 |