| Schengen Pathways Limited | Administrative & support | 2025 |
| School Service Mini BUS Limited | Transport & logistics | 2002 |
| Sciachem Limited | Wholesale & retail | 2005 |
| Scientience Limited | Information & communication | 2016 |
| SCM 2025 Ltd | Information & communication | 2025 |
| Scorpionwang Consultancy Limited | Professional & scientific | 2022 |
| Scot Trade Consultancy Services Ltd | Professional & scientific | 2022 |
| Scott Bradley Accountants and Tax Consultants Ltd. | Professional & scientific | 2013 |
| Scott One Consulting Limited | Professional & scientific | 2024 |
| Scott Taylor Management Services Limited | Professional & scientific | 2024 |
| Scripto-Mate Ltd | Information & communication | 2025 |
| SD Nursing Care Ltd | Health & social care | 2023 |
| SD Transfers Ltd | Transport & logistics | 2022 |
| SD Wellness Limited | Professional & scientific | 2022 |
| Sdav Properties Limited | Real estate | 2025 |
| SDB National Limited | Financial services | 2024 |
| Sdetails Ltd | Other services | 2018 |
| SDG Hydronics Ltd | Construction | 2024 |
| SDG Training Ltd | Education | 2024 |
| Sdjmedia Ltd | Information & communication | 2020 |
| SDK Consultancy Limited | Professional & scientific | 2019 |
| SDL Trans Ltd | Transport & logistics | 2023 |
| SDN Builders UK Ltd | Construction | 2025 |
| Sea and Land Equipment Limited | Transport & logistics | 1988 |
| Sea Bass Entertainment Ltd | Arts & recreation | 2024 |
| Seabeck Solutions Limited | Wholesale & retail | 2020 |
| Seabest Limited | Wholesale & retail | 2001 |
| Seagate Productions Limited | Information & communication | 2006 |
| Seagrive Construction Ltd | Construction | 2019 |
| Searman Pembertons Limited | Professional & scientific | 2017 |
| Seas Capital Ltd | Financial services | 2026 |
| Seasoned With Love Ltd | Hospitality | 2026 |
| Seasons Property Limited | Other services | 2023 |
| Seat 1A Limited | Transport & logistics | 2007 |
| Seaview Ideas Ltd | Hospitality | 2018 |
| Seb-Ed Ltd | Construction | 2023 |
| Sebastian Potoroaca Limited | Construction | 2025 |
| Sebastian.Management Limited | Construction | 2016 |
| Sebstef Ltd | Transport & logistics | 2025 |
| Second Pilgrims Management Company Limited | Households | 1985 |
| Secta Building Services Limited | Construction | 2006 |
| Sector 3 Service Limited | Professional & scientific | 2011 |
| Securecore Solutions Limited | Information & communication | 2026 |
| Security Comfort UK Ltd | Administrative & support | 2021 |
| SECURITYGATES4YOU Limited | Construction | 2013 |
| Sedkel Limited | Professional & scientific | 2010 |
| Sedna Bast Limited | Professional & scientific | 2013 |
| Sedona Digital GOV Ltd | Information & communication | 2022 |
| Sedona Digital Ltd | Information & communication | 2019 |
| Sedulous Group Ltd | Administrative & support | 2021 |
| Sedulous Leasing Ltd | Administrative & support | 2021 |
| Seedcare Limited | Real estate | 1981 |
| Seeme Daily Ltd | Wholesale & retail | 2026 |
| SEF Engineering Limited | Manufacturing | 2008 |
| Sefgo Limited | Professional & scientific | 2011 |
| Sefid Smile Limited | Health & social care | 2022 |
| Seger Legal Limited | Professional & scientific | 2023 |
| Selcroft Trustee Ltd | Administrative & support | 2018 |
| Sellbridge Limited | Financial services | 1994 |
| Sellowed Limited | Wholesale & retail | 2025 |
| Selvel Limited | Real estate | 2013 |
| Selvi Capital Limited | Professional & scientific | 2021 |
| Sema Services Ltd | Professional & scientific | 2017 |
| Sen&Ben Ltd | Construction | 2022 |
| Sena Julia Publicatus Limited | Information & communication | 1993 |
| Sender International Ltd | Professional & scientific | 2019 |
| Sene Construction Ltd | Construction | 2019 |
| Senergy Ltd | Professional & scientific | 2023 |
| Seng Limited | Real estate | 2025 |
| Senior & Junior Building Services Ltd | Construction | 2020 |
| Sens Samadi Limited | Professional & scientific | 2025 |
| Sensations Holdings Limited | Real estate | 1997 |
| Sensesos Ltd | Information & communication | 2026 |
| Sensory Activation Solutions Ltd | Health & social care | 2010 |
| Sentient Communications Ltd | Professional & scientific | 2013 |
| Sephira Investments Ltd | Information & communication | 2018 |
| Septime Capital Limited | Professional & scientific | 2024 |
| Septime PSC Limited | Professional & scientific | 2025 |
| Seqoya JV1 Limited | Real estate | 2014 |
| Seqoya Ltd | Real estate | 2011 |
| Sequence Properties Limited | Real estate | 2012 |
| Sequoia Mortgages Limited | Financial services | 2012 |
| Seraph Cars GB Limited | Wholesale & retail | 2012 |
| Serdnol Property Management Ltd | Households | 2021 |
| Serenade Events Limited | Other services | 2025 |
| Seret International Limited | Education | 2012 |
| Serghei Construction Ltd | Construction | 2019 |
| Sergial Ltd | Construction | 2024 |
| Seriouslycinema Limited | Wholesale & retail | 2015 |
| Servado Limited | Professional & scientific | 2019 |
| Serve Best Company Ltd | Health & social care | 2020 |
| Served by Regal Ltd. | Wholesale & retail | 2023 |
| Servicespro Ltd | Wholesale & retail | 2019 |
| Sesqui Consulting Ltd | Information & communication | 2021 |
| Settara Ltd | Wholesale & retail | 2026 |
| Seven Art Ltd | Information & communication | 2003 |
| Seven Sky Constructs Ltd | Construction | 2026 |
| Seven Star ARC Ltd | Wholesale & retail | 2018 |
| Sevenkode Ltd | Information & communication | 2024 |
| SFR Motors Ltd | Wholesale & retail | 2024 |