| SAM Tillers Ltd | Construction | 2025 |
| Samas Assets Ltd | Real estate | 2023 |
| Samba Panda Studios Limited | Extraterritorial | 2012 |
| Samba Sandals Limited | Wholesale & retail | 2025 |
| Sameness Ltd | Wholesale & retail | 2025 |
| Samet and Associates Ltd | Professional & scientific | 2020 |
| Sammridhi Limited | Real estate | 2024 |
| Sampson & Sampson Ltd | Health & social care | 2020 |
| Sams Foods Ltd | Hospitality | 2019 |
| Samshri Property Limited | Real estate | 2025 |
| Samson V Limited | Real estate | 2021 |
| Samta Limited | Health & social care | 2015 |
| Samuel Edgar Ltd | Construction | 2009 |
| Samuijan Ltd | Wholesale & retail | 2026 |
| San-U Claning Ltd | Administrative & support | 2026 |
| SAN7 Investment Ltd | Other services | 2024 |
| Sana Desserts Limited | Hospitality | 2025 |
| Sanama Limited | Real estate | 2021 |
| Sancera Ltd | Construction | 2023 |
| Sanco Global Mortgage & Financial Services Ltd | Financial services | 2019 |
| Sandav Developments Limited | Real estate | 2016 |
| Sandown Bakeries Limited | Wholesale & retail | 2010 |
| SANDSTON3 Ltd | Construction | 2024 |
| Sandvr Ltd | Professional & scientific | 2022 |
| Sangerwal Money Transfer Services Ltd | Financial services | 2004 |
| Sangul Properties Ltd | Real estate | 2020 |
| Sanlaw Properties Limited | Real estate | 2000 |
| Sanoire Ltd | Wholesale & retail | 2025 |
| Sanopharm Limited | Wholesale & retail | 2022 |
| Sansaar-Uk Ltd | Health & social care | 2018 |
| Sansas Technical Limited | Administrative & support | 2011 |
| Santech International Limited | Wholesale & retail | 2001 |
| Santish Ltd | Real estate | 2025 |
| Santish Supplies Ltd | Wholesale & retail | 2026 |
| Santuary Support Alliance CIC | Hospitality | 2024 |
| Sapna Caterers Limited | Hospitality | 1998 |
| Sapna Estates Limited | Real estate | 2016 |
| Sapna FS Limited | Hospitality | 2020 |
| Sapphire Bridal (London) Ltd | Wholesale & retail | 2023 |
| Sapphire Dust Limited | Wholesale & retail | 2019 |
| Sapphire RH Investments Ltd | Real estate | 2025 |
| Sapphire RH Limited | Information & communication | 2022 |
| Saptatek Limited | Information & communication | 2021 |
| Sapteck Systems Limited | Information & communication | 2017 |
| Saqeefah Limited | Real estate | 2022 |
| Sara & Brothers Ltd | Hospitality | 2015 |
| Sara Care Home Limited | Health & social care | 2008 |
| Sara Home Care Ltd | Health & social care | 2024 |
| Sara Levy Limited | Health & social care | 2015 |
| Sara.P Ltd | Information & communication | 2015 |
| Saracens Multi-Academy Trust | Education | 2017 |
| Sarah Design Hub Limited | Wholesale & retail | 2026 |
| Sarah Louise Smith Limited | Other services | 2014 |
| Saraman Limited | Professional & scientific | 2026 |
| Sarcarin Ltd | Construction | 2022 |
| Sarjeng Limited | Professional & scientific | 2022 |
| Sarju Ltd | Wholesale & retail | 2017 |
| Sarthak Investments LLP | | 2025 |
| Sarview Limited | Professional & scientific | 2005 |
| Saseethai Ltd | Wholesale & retail | 2023 |
| Sass Living Limited | Real estate | 2025 |
| Sass Management Limited | Real estate | 2009 |
| Satar Ltd | Hospitality | 2025 |
| Satk Holdings Limited | Financial services | 2025 |
| Satyasankalp Energy Ltd | Construction | 2025 |
| Satz International Ltd | Education | 2022 |
| SAV Consulting Limited | Information & communication | 2013 |
| Savannah Communications Limited | Information & communication | 2019 |
| Savithra Ltd | Health & social care | 2020 |
| Savloni UK Ltd | Other services | 2024 |
| SAW19KITCHEN Ltd | Hospitality | 2024 |
| Saxeway Drive Limited | Households | 2021 |
| Saxons Invest Ltd | Real estate | 2024 |
| Saxons Invest Mowbray Ltd | Real estate | 2025 |
| Saying YES Consultancy Limited | Professional & scientific | 2025 |
| Saywack Ltd | Financial services | 2023 |
| Sazon Autos Limited | Other services | 2021 |
| SB Housing Solutions Ltd | Administrative & support | 2025 |
| SBA Cars Ltd | Wholesale & retail | 2019 |
| SBA Fast Feast Limited | Hospitality | 2024 |
| SBK Advisory Limited | Professional & scientific | 2017 |
| SBK Building Services Ltd | Construction | 2023 |
| SBR Services Limited | Construction | 2017 |
| Sbsh Ltd | Construction | 2025 |
| SC Asset Finance Limited | Arts & recreation | 2026 |
| SCA Analytics Ltd | Financial services | 2019 |
| SCA Dunstable Ltd | Education | 2017 |
| Scalar Solutions Limited | Professional & scientific | 2018 |
| Scale Agency Limited | Professional & scientific | 2025 |
| Scaleacquire.Io Ltd | Other services | 2025 |
| Scalfi & Eghenter Ltd | Arts & recreation | 2015 |
| Scandi Distro Limited | Wholesale & retail | 2021 |
| Scaped London Limited | Other services | 2025 |
| Scarfato Ceramiche Limited | Construction | 2015 |
| Scarlet Tools Ltd | Wholesale & retail | 2012 |
| Scent by 7 Ltd | Wholesale & retail | 2021 |
| Sceptre Limited | Real estate | 2023 |
| Scerinity Ltd | Wholesale & retail | 2023 |
| Scgoldharbour Ltd | Hospitality | 2019 |
| Schema Creative Ltd | Information & communication | 2026 |