| Rossca Consulting Limited | Information & communication | 2011 |
| Rossell Properties Ltd | Households | 2024 |
| Rossi & M Ltd | Administrative & support | 2022 |
| Rostam Holdings Ltd | Real estate | 2020 |
| Rother GP Service Ltd | Health & social care | 2019 |
| Rother Healthcare Limited | Health & social care | 2016 |
| Rother Kebab Ltd | Hospitality | 2025 |
| Rotorsol Limited | Extraterritorial | 2013 |
| Roxborough House RTM Company Limited | Households | 2020 |
| Roxwell Contracts Limited | Real estate | 1996 |
| Roxwell Limited | Construction | 1988 |
| Royale Lottbridge Farm Holdings Ltd | Agriculture & fishing | 2026 |
| Royale Lottbridge Holdings Limited | Financial services | 2024 |
| Royale Quarters Limited | Real estate | 2020 |
| RP Event Solutions Limited | Extraterritorial | 2017 |
| Rp&P Ltd | Financial services | 2020 |
| RPA Safety Ltd | Professional & scientific | 2024 |
| RPM Body Shop Ltd | Wholesale & retail | 2013 |
| RPM Capital Ltd | Financial services | 2019 |
| RPT Foods Limited | Hospitality | 2017 |
| RR Dental Limited | Health & social care | 2025 |
| RS Loveland Property Ltd | Real estate | 2025 |
| RS Orthodontics Limited | Health & social care | 2024 |
| RS Plumbing and Heating (Sussex) Limited | Construction | 2025 |
| RS Projects Limited | Professional & scientific | 2021 |
| RS3 Developments Limited | Households | 2013 |
| RSH Roofing Limited | Construction | 2016 |
| RSS Automotive Limited | Wholesale & retail | 2020 |
| RSW Management Ltd | Professional & scientific | 2016 |
| RTJ of Sussex Ltd | Public administration | 2023 |
| RU UK Enterprises Ltd | Information & communication | 2025 |
| Rubia Property Management Ltd | Households | 2025 |
| Rubislaw Court (Eastbourne) RTM Company Limited | Households | 2026 |
| Rubix Construction and Development Ltd | Construction | 2015 |
| Rufusia Ltd | Administrative & support | 2024 |
| Rumd Holdings Ltd | Financial services | 2019 |
| Rumd Investments Ltd | Financial services | 2019 |
| Rumd Ltd | Health & social care | 2015 |
| Rumd Property Investments Ltd | Real estate | 2019 |
| Rumore Oak Limited | Construction | 2025 |
| Runfold Motor Company Limited | Wholesale & retail | 2000 |
| Rupri Ltd | Wholesale & retail | 2026 |
| Rush Productions Limited | Information & communication | 2018 |
| Ruslake Limited | Hospitality | 2018 |
| Russ Deacon Home Improvements Limited | Wholesale & retail | 2004 |
| Russguild Properties Limited | Households | 1987 |
| Rustic Robin Limited | Wholesale & retail | 2016 |
| Rusty Wheel Ltd | Professional & scientific | 2020 |
| Rutherfords 360 Limited | Real estate | 2024 |
| Rutherfords Bailiffs and Collection Services Limited | Financial services | 2016 |
| Rutherfords Rentals Ltd | Real estate | 2021 |
| RVC Property Ltd | Real estate | 2023 |
| Rvka Ltd | Wholesale & retail | 2024 |
| RW Management Services Ltd | Real estate | 2022 |
| RWA Dental Ltd | Health & social care | 2018 |
| RWJ Porter Ltd | Health & social care | 2011 |
| Rydal Mount (Eastbourne) Limited | Households | 1979 |
| Ryefield Gardening Limited | Construction | 2004 |
| Rylyn Ltd | Professional & scientific | 2026 |
| Rymic Construction Limited | Construction | 1992 |
| Rymon Limited | Health & social care | 2024 |
| S & J Building Contractors LLP | | 2025 |
| S B Interior Salvage Limited | Other services | 2014 |
| S B Motors (Hove) LLP | | 2013 |
| S C Design Associates Limited | Professional & scientific | 2006 |
| S Chambers Cleaning Services Ltd | Administrative & support | 2016 |
| S Collison Limited | Construction | 2021 |
| S D Mckay Groundworks Limited | Administrative & support | 2005 |
| S F G Ventures Limited | Information & communication | 2011 |
| S J Fencing Limited | Construction | 2006 |
| S J Hawkins Electrical Limited | Construction | 2009 |
| S J Pankhania Services Limited | Health & social care | 2015 |
| S LC Resolution Ltd | Wholesale & retail | 2025 |
| S P Dairy Services Ltd | Agriculture & fishing | 2013 |
| S P R Electrical Limited | Construction | 2007 |
| S Pitcher Limited | Construction | 2003 |
| S R Welfare Electrical Limited | Construction | 2007 |
| S Squared Limited | Professional & scientific | 2026 |
| S&A Worrall Property Limited | Real estate | 2026 |
| S&K Roofing Ltd | Construction | 2025 |
| S&L Maintenance Eastbourne Limited | Households | 2022 |
| S&S Dental Ltd | Health & social care | 2015 |
| S&S Shah Property Ltd | Real estate | 2015 |
| S&Y Sharp Holdings Ltd | Financial services | 2025 |
| S. WU & Family Limited | Real estate | 2021 |
| S.A.K. Equipment Limited | Manufacturing | 1974 |
| S.Dot Creative Ltd. | Professional & scientific | 2017 |
| S.F. Property Buyers Ltd | Real estate | 2023 |
| S.M.C. Homes Limited | Real estate | 2016 |
| S.M.D. Formwork Holdings Limited | Construction | 2018 |
| S2S Beauty and Wellbeing Services Ltd | Health & social care | 2022 |
| S3 Studios Ltd | Arts & recreation | 2017 |
| S7REAM Ltd | Information & communication | 2021 |
| Sabaidee Limited | Hospitality | 2011 |
| Sackville Automotive Ltd | Wholesale & retail | 2025 |
| Safana Dental & Facial Aesthetics Clinic Limited | Other services | 2010 |
| Safeguarding Against Abuse Limited | Health & social care | 2017 |
| Safer Trader Ltd | Education | 2020 |
| Safer. Health and Safety Limited | Administrative & support | 2015 |
| Saferise Home Improvements Limited | Construction | 2018 |